| DISEASE | TITLE OF PUBLICATION | LINK TO PUBMED |
| Adenoma, Islet Cell | Defective regulation of glucokinase in rat pancreatic islet cell tumours. |  PubMed |
| Anemia | [Leading criteria of reticulocyte maturation. 3. Behavior of hexokinase and glucokinase of red blood cells during a bleeding anemia of the rabbit] | PubMed |
| Blood Group Incompatibility | [Glucokinase activity of the myocardium, skeletal muscles, kidneys and bone marrow in transfusion reactions in dogs] | PubMed |
| Burkitt Lymphoma | Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening. | PubMed |
| Carcinoma | Carbohydrate metabolism in human renal clear cell carcinomas. | PubMed |
| Carcinoma | Isoenzyme shift from glucokinase to hexokinase is not an early but a late event in hepatocarcinogenesis. | PubMed |
| Carcinoma, Hepatocellular | A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme. | PubMed |
| Carcinoma, Hepatocellular | Alteration of enzyme function of the type II hexokinase C-terminal half on replacements of restricted regions by corresponding regions of glucokinase. | PubMed |
| Carcinoma, Hepatocellular | Characterization of the 5' flanking region of rat glucokinase gene. | PubMed |
| Carcinoma, Hepatocellular | Glucokinase expression in rat hepatoma cells induces glucose uptake and is rate limiting in glucose utilization. | PubMed |
| Carcinoma, Hepatocellular | Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver. | PubMed |
| Carcinoma, Hepatocellular | Identification of upstream stimulatory factor as transcriptional activator of the liver promoter of the glucokinase gene. | PubMed |
| Carcinoma, Hepatocellular | Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro. | PubMed |
| Carcinoma, Hepatocellular | Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase. | PubMed |
| Carcinoma, Hepatocellular | Liver-specific enhancer of the glucokinase gene. | PubMed |
| Carcinoma, Hepatocellular | The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. | PubMed |
| Carcinoma, Hepatocellular | [Activity of enzymes of glycolysis and gluconeogenesis in primary hepatomas induced by diethylnitrosamine] | PubMed |
| Carcinoma, Hepatocellular | [Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis] | PubMed |
| Carcinoma, Hepatocellular | [Biochemical features of the liver of high and low cancer mouse strains and primary spontaneous hepatomas] | PubMed |
| Carcinoma, Hepatocellular | [CHANGES IN GLUCOKINASE AND HEXOKINASE CONTENT OF THE RAT LIVER AFTER FASTING, DURING CARCINOGENESIS AND IN PRIMARY AND TRANSPLANTED HEPATOMA.] | PubMed |
| Carcinoma, Hepatocellular | [Noradrenaline and glycogen content and the activity of several enzymes of carbohydrate metabolism in normal, embryonic, and partly denervated livers and in hepatomas of the rat] | PubMed |
| Carcinoma, Hepatocellular | [Some characteristics of isoenzymic spectrum of hexokinase and glucose levels in hepatomas and liver of the host] | PubMed |
| Colonic Neoplasms | Genetic approaches to common diseases. | PubMed |
| Colorectal Neoplasms | Genetic Variants, Prediagnostic Circulating Levels of Insulin-like Growth Factors, Insulin, and Glucose and the Risk of Colorectal Cancer: The Multiethnic Cohort Study. | PubMed |
| Coma | Effect of total hepatectomy on selected cerebral substrates and enzymes of the glycolytic pathways and Krebs cycle. | PubMed |
| Congenital Hyperinsulinism | Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation. | PubMed |
| Congenital Hyperinsulinism | Diagnostic difficulties in glucokinase hyperinsulinism. | PubMed |
| Congenital Hyperinsulinism | Hyperinsulinism in infancy and childhood: when an insulin level is not always enough. | PubMed |
| Congenital Hyperinsulinism | Mechanisms of Disease: advances in diagnosis and treatment of hyperinsulinism in neonates. | PubMed |
| Congenital Hyperinsulinism | [Hyperinsulinism in infancy and childhood: when an insulin level is not always enough.] | PubMed |
| Coronary Artery Disease | G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus. | PubMed |
| Diabetes Complications | Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q. | PubMed |
| Diabetes Mellitus | A genetic marker at the glucokinase gene locus for type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles. | PubMed |
| Diabetes Mellitus | A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria. | PubMed |
| Diabetes Mellitus | A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study). | PubMed |
| Diabetes Mellitus | Characterization of a third simple tandem repeat polymorphism in the human glucokinase gene. | PubMed |
| Diabetes Mellitus | Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA(Leu(UUR)) genes. | PubMed |
| Diabetes Mellitus | Diabetes mellitus and glucokinase. | PubMed |
| Diabetes Mellitus | Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. | PubMed |
| Diabetes Mellitus | Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. | PubMed |
| Diabetes Mellitus | Early-onset type 2 (non-insulin-dependent) diabetes mellitus is associated with glucokinase locus, but not with adenosine deaminase locus, in the Japanese population. | PubMed |
| Diabetes Mellitus | Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1 alpha and glucokinase. | PubMed |
| Diabetes Mellitus | Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. | PubMed |
| Diabetes Mellitus | Four novel cases of permanent neonatal diabetes mellitus caused by homozygous mutations in the glucokinase gene. | PubMed |
| Diabetes Mellitus | G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus. | PubMed |
| Diabetes Mellitus | Glucokinase and candidate genes for type 2 (non-insulin-dependent) diabetes mellitus. | PubMed |
| Diabetes Mellitus | Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. | PubMed |
| Diabetes Mellitus | Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning. | PubMed |
| Diabetes Mellitus | Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy. | PubMed |
| Diabetes Mellitus | Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. | PubMed |
| Diabetes Mellitus | Glucokinase mutations, insulin secretion, and diabetes mellitus. | PubMed |
| Diabetes Mellitus | Glucokinase, glucose homeostasis, and diabetes mellitus. | PubMed |
| Diabetes Mellitus | High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population. | PubMed |
| Diabetes Mellitus | High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP). | PubMed |
| Diabetes Mellitus | Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus. | PubMed |
| Diabetes Mellitus | Human islet glucokinase gene. Isolation and sequence analysis of full-length cDNA. | PubMed |
| Diabetes Mellitus | Human pancreatic beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p 13. | PubMed |
| Diabetes Mellitus | Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice. | PubMed |
| Diabetes Mellitus | Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families. | PubMed |
| Diabetes Mellitus | Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus. | PubMed |
| Diabetes Mellitus | Identification of glucokinase mutations in subjects with gestational diabetes mellitus. | PubMed |
| Diabetes Mellitus | Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism. | PubMed |
| Diabetes Mellitus | Linkage analysis does not support a role for glucokinase gene in the aetiology of type 2 diabetes mellitus among north western Italians. | PubMed |
| Diabetes Mellitus | Linkage analysis of the glucokinase locus in familial type 2 (non-insulin-dependent) diabetic pedigrees. | PubMed |
| Diabetes Mellitus | Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. | PubMed |
| Diabetes Mellitus | Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus. | PubMed |
| Diabetes Mellitus | Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY. | PubMed |
| Diabetes Mellitus | Molecular screening of the glucokinase gene in familial type 2 (non-insulin-dependent) diabetes mellitus. | PubMed |
| Diabetes Mellitus | Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus. | PubMed |
| Diabetes Mellitus | Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects. | PubMed |
| Diabetes Mellitus | Mutations of the human glucokinase gene and diabetes mellitus. | PubMed |
| Diabetes Mellitus | Neonatal diabetes mellitus due to complete glucokinase deficiency. | PubMed, PubMed |
| Diabetes Mellitus | New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer). | PubMed |
| Diabetes Mellitus | NIDDM--genetic marker; glucose transporter, glucokinase, and mitochondria gene. | PubMed |
| Diabetes Mellitus | Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. | PubMed |
| Diabetes Mellitus | Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy. | PubMed |
| Diabetes Mellitus | Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study. | PubMed |
| Diabetes Mellitus | Polymorphism of glucokinase gene in non-insulin dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus | Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians. | PubMed |
| Diabetes Mellitus | Repair of diverse diabetic defects of ?-cells in man and mouse by pharmacological glucokinase activation. | PubMed |
| Diabetes Mellitus | Routine mutation screening of HNF-1alpha and GCK genes in MODY diagnosis: how effective are the techniques of DHPLC and direct sequencing used in combination? | PubMed |
| Diabetes Mellitus | Safety, pharmacokinetics and pharmacodynamics of multiple-ascending doses of the novel glucokinase activator AZD1656 in patients with type 2 diabetes mellitus. | PubMed |
| Diabetes Mellitus | Screening of mutations and polymorphisms in the glucokinase gene in Czech diabetic and healthy control populations. | PubMed |
| Diabetes Mellitus | Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients. | PubMed |
| Diabetes Mellitus | Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. | PubMed |
| Diabetes Mellitus | Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2). | PubMed |
| Diabetes Mellitus | The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS). | PubMed |
| Diabetes Mellitus | The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent. | PubMed |
| Diabetes Mellitus | The population association of glucokinase gene with type 2 (noninsulin-dependent) diabetes mellitus in Chinese. | PubMed |
| Diabetes Mellitus | Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online. | PubMed |
| Diabetes Mellitus | Tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator AZD1656, after single ascending doses in healthy subjects during euglycemic clamp. | PubMed |
| Diabetes Mellitus | Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with type 2 (non-insulin-dependent) diabetes mellitus. | PubMed |
| Diabetes Mellitus | Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family. | PubMed |
| Diabetes Mellitus | [Clinical studies on the serum glucokinase activity values. 1. Erythrocyte glucokinase activity values in normal infants and children, in ekiri-like syndrome, in diabetes mellitus, and in liver diseases.] | PubMed |
| Diabetes Mellitus | [Diabetes susceptibility genes] | PubMed |
| Diabetes Mellitus | [Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery] | PubMed |
| Diabetes Mellitus, Experimental | [Incorporation of S35 labelled methionine in the liver proteins of rats with alloxan diabetes in conditions of block or 'circumvention' of the glucokinase reaction.] | PubMed |
| Diabetes Mellitus, Type 1 | Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations. | PubMed |
| Diabetes Mellitus, Type 1 | Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes. | PubMed |
| Diabetes Mellitus, Type 1 | Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7. | PubMed |
| Diabetes Mellitus, Type 1 | Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 1 | Recovery of pancreatic beta cells in response to long-term normoglycemia after pancreas or islet transplantation in severely streptozotocin diabetic adult rats. | PubMed |
| Diabetes Mellitus, Type 1 | The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS). | PubMed |
| Diabetes Mellitus, Type 2 | A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. | PubMed |
| Diabetes Mellitus, Type 2 | A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria. | PubMed |
| Diabetes Mellitus, Type 2 | A missense mutation in the hepatocyte nuclear factor 4 alpha gene in a UK pedigree with maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | A missense mutation, Val62Ala, in the glucokinase gene in a Norwegian family with maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | A new missense mutation in the glucokinase gene in an Italian Mody family. | PubMed |
| Diabetes Mellitus, Type 2 | A novel glucokinase gene mutation and its effect on glycemic/C-peptide fluctuations in a patient with maturity-onset diabetes of the young type 2. | PubMed |
| Diabetes Mellitus, Type 2 | A novel mutation in exon 5 of the glucokinase gene in an Argentinian family with maturity onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene. | PubMed |
| Diabetes Mellitus, Type 2 | Agonist: the case for insulin resistance as a necessary and sufficient cause of type II diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. | PubMed |
| Diabetes Mellitus, Type 2 | An integrated view of beta-cell dysfunction in type-II diabetes. | PubMed |
| Diabetes Mellitus, Type 2 | Analysis of the glucokinase gene in Mexican families displaying early-onset non-insulin-dependent diabetes mellitus including MODY families. | PubMed |
| Diabetes Mellitus, Type 2 | Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. | PubMed |
| Diabetes Mellitus, Type 2 | Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations. | PubMed |
| Diabetes Mellitus, Type 2 | ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes. | PubMed |
| Diabetes Mellitus, Type 2 | beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors. | PubMed |
| Diabetes Mellitus, Type 2 | beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations. | PubMed |
| Diabetes Mellitus, Type 2 | Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients. | PubMed |
| Diabetes Mellitus, Type 2 | CA-repeated microsatellite polymorphism of the glucokinase gene and its association with non-insulin-dependent diabetes mellitus in Taiwanese. | PubMed |
| Diabetes Mellitus, Type 2 | Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase. | PubMed |
| Diabetes Mellitus, Type 2 | Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI). | PubMed |
| Diabetes Mellitus, Type 2 | Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype. | PubMed |
| Diabetes Mellitus, Type 2 | Characterization of glucokinase polymorphisms associated with maturity-onset diabetes of the young (MODY2) in Jordanian population. | PubMed |
| Diabetes Mellitus, Type 2 | Clinically-Defined Maturity Onset Diabetes of the Young in Omanis: Absence of the common Caucasian gene mutations. | PubMed |
| Diabetes Mellitus, Type 2 | Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes. | PubMed |
| Diabetes Mellitus, Type 2 | Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. | PubMed |
| Diabetes Mellitus, Type 2 | Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q. | PubMed |
| Diabetes Mellitus, Type 2 | Diabetes: from phenotypes to genotypes. | PubMed |
| Diabetes Mellitus, Type 2 | Diagnosis in diabetes: does it matter? | PubMed |
| Diabetes Mellitus, Type 2 | Diagnosis of maturity-onset diabetes of the young in the pediatric diabetes clinic. | PubMed |
| Diabetes Mellitus, Type 2 | Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. | PubMed |
| Diabetes Mellitus, Type 2 | Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability. | PubMed |
| Diabetes Mellitus, Type 2 | Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes. | PubMed |
| Diabetes Mellitus, Type 2 | Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Four novel mutations, including the first gross deletion in TCF1, identified in HNF-4alpha, GCK and TCF1 in patients with MODY in Israel. | PubMed |
| Diabetes Mellitus, Type 2 | From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. | PubMed |
| Diabetes Mellitus, Type 2 | G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY). | PubMed |
| Diabetes Mellitus, Type 2 | Genetic analysis of glucokinase and the chromosome 20 diabetes susceptibility locus in families with type 2 diabetes. | PubMed |
| Diabetes Mellitus, Type 2 | Genetic and clinical characteristics of Korean maturity-onset diabetes of the young (MODY) patients. | PubMed |
| Diabetes Mellitus, Type 2 | Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patients. | PubMed |
| Diabetes Mellitus, Type 2 | Genetic basis of maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Genetic testing for glucokinase mutations in clinically selected patients with MODY: a worthwhile investment. | PubMed |
| Diabetes Mellitus, Type 2 | Genetic testing for maturity onset diabetes of the young in childhood hyperglycaemia. | PubMed |
| Diabetes Mellitus, Type 2 | Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians. | PubMed |
| Diabetes Mellitus, Type 2 | Genetics of non-insulin-dependent (type-II) diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Genetics of type 2 diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Genomic analysis of five chromosome 7p deletion patients with Greig cephalopolysyndactyly syndrome (GCPS). | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase and MODY: from the gene to the disease. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase and NIDDM. A candidate gene that paid off. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene is genetic marker for NIDDM in American blacks. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene mutation linked to early-onset NIDDM. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase Gene Mutation Screening in Argentinean Clinically Characterized MODY Patients. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene polymorphisms: a genetic marker for glucose intolerance in a cohort of elderly Finnish men. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene variants in Chinese subjects with the common form of NIDDM. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene variants in the common form of NIDDM. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase gene variations in Japanese-Americans with a family history of NIDDM. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase mutations, insulin secretion, and diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression. | PubMed |
| Diabetes Mellitus, Type 2 | Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. | PubMed |
| Diabetes Mellitus, Type 2 | Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. | PubMed |
| Diabetes Mellitus, Type 2 | Haploinsufficiency at GCK gene is not a frequent event in MODY2 patients. | PubMed |
| Diabetes Mellitus, Type 2 | Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene. | PubMed |
| Diabetes Mellitus, Type 2 | Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians. | PubMed |
| Diabetes Mellitus, Type 2 | Hepatocyte nuclear factor 1 alpha (HNF-1 alpha) mutations in maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | High frequency of mutations in MODY and mitochondrial genes in Scandinavian patients with familial early-onset diabetes. | PubMed |
| Diabetes Mellitus, Type 2 | High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP). | PubMed |
| Diabetes Mellitus, Type 2 | High-resolution electrospray ionization Fourier transform mass spectrometry with infrared multiphoton dissociation of glucokinase from Bacillus Stearothermophilus. | PubMed |
| Diabetes Mellitus, Type 2 | Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism. | PubMed |
| Diabetes Mellitus, Type 2 | Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. | PubMed |
| Diabetes Mellitus, Type 2 | Identification and functional characterisation of novel glucokinase mutations causing maturity-onset diabetes of the young in Slovakia. | PubMed |
| Diabetes Mellitus, Type 2 | Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families. | PubMed |
| Diabetes Mellitus, Type 2 | Identification of 21 novel glucokinase (GCK) mutations in UK and European Caucasians with maturity-onset diabetes of the young (MODY). | PubMed |
| Diabetes Mellitus, Type 2 | Identification of eight novel glucokinase mutations in Italian children with maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Identification of glucokinase mutations in subjects with gestational diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Identification of novel GCK and HNF1A/TCF1 mutations and polymorphisms in German families with maturity-onset diabetes of the young (MODY). | PubMed |
| Diabetes Mellitus, Type 2 | Identification of two new mutations in the glucokinase gene that result in maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research. | PubMed |
| Diabetes Mellitus, Type 2 | Linkage analysis and molecular scanning of glucokinase gene in NIDDM families. | PubMed |
| Diabetes Mellitus, Type 2 | Linkage analysis does not support a role for glucokinase gene in the aetiology of type 2 diabetes mellitus among north western Italians. | PubMed |
| Diabetes Mellitus, Type 2 | Linkage analysis of acute insulin secretion with GLUT2 and glucokinase in Pima Indians and the identification of a missense mutation in GLUT2. | PubMed |
| Diabetes Mellitus, Type 2 | Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees. | PubMed |
| Diabetes Mellitus, Type 2 | Linkage analysis of the genetic markers of the candidate genes with non-insulin dependent diabetes mellitus in Chinese families. | PubMed |
| Diabetes Mellitus, Type 2 | Linkage analysis of the glucokinase locus in familial type 2 (non-insulin-dependent) diabetic pedigrees. | PubMed |
| Diabetes Mellitus, Type 2 | Linkage of maturity-onset diabetes of the young to the glucokinase gene--evidence of genetic heterogeneity. | PubMed |
| Diabetes Mellitus, Type 2 | Linkage of type 2 diabetes to the glucokinase gene. | PubMed |
| Diabetes Mellitus, Type 2 | Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2). | PubMed |
| Diabetes Mellitus, Type 2 | Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2. | PubMed |
| Diabetes Mellitus, Type 2 | Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis. | PubMed |
| Diabetes Mellitus, Type 2 | Maturity onset diabetes of the young (MODY). | PubMed |
| Diabetes Mellitus, Type 2 | Maturity-onset diabetes of the young (MODY): a new challenge for pediatric diabetologists. | PubMed |
| Diabetes Mellitus, Type 2 | Maturity-onset diabetes of the young. | PubMed, PubMed |
| Diabetes Mellitus, Type 2 | Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity. | PubMed |
| Diabetes Mellitus, Type 2 | Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization. | PubMed |
| Diabetes Mellitus, Type 2 | Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers. | PubMed |
| Diabetes Mellitus, Type 2 | Microsatellite polymorphisms at the glucokinase locus: a population association study in Caucasian type 2 diabetic subjects. | PubMed |
| Diabetes Mellitus, Type 2 | Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes. | PubMed |
| Diabetes Mellitus, Type 2 | Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit. | PubMed |
| Diabetes Mellitus, Type 2 | Mitochondrial diabetes: molecular mechanisms and clinical presentation. | PubMed |
| Diabetes Mellitus, Type 2 | Molecular and biochemical analysis of the MODY syndromes. | PubMed |
| Diabetes Mellitus, Type 2 | Molecular genetics goes to the diabetes clinic. | PubMed |
| Diabetes Mellitus, Type 2 | Molecular Genetics of Maturity-onset Diabetes of the Young. | PubMed |
| Diabetes Mellitus, Type 2 | Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B. | PubMed |
| Diabetes Mellitus, Type 2 | Molecular targeting of pancreatic disorders. | PubMed |
| Diabetes Mellitus, Type 2 | Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. | PubMed |
| Diabetes Mellitus, Type 2 | Monogenic forms of obesity and diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Mutation screening in 18 Caucasian families suggest the existence of other MODY genes. | PubMed |
| Diabetes Mellitus, Type 2 | Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) | PubMed |
| Diabetes Mellitus, Type 2 | NIDDM--genetic marker; glucose transporter, glucokinase, and mitochondria gene. | PubMed |
| Diabetes Mellitus, Type 2 | Nine novel mutations in maturity-onset diabetes of the young (MODY) candidate genes in 22 Spanish families. | PubMed |
| Diabetes Mellitus, Type 2 | Non-insulin dependent diabetes--the past, present and future. | PubMed |
| Diabetes Mellitus, Type 2 | Nonradioactive screening of glucokinase mutations in maturity onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q. | PubMed |
| Diabetes Mellitus, Type 2 | Nuclear magnetic resonance studies of hepatic glucose metabolism in humans. | PubMed |
| Diabetes Mellitus, Type 2 | Pancreatic pathology in non-insulin dependent diabetes (NIDDM). | PubMed |
| Diabetes Mellitus, Type 2 | Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2). | PubMed |
| Diabetes Mellitus, Type 2 | Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study. | PubMed |
| Diabetes Mellitus, Type 2 | Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese. | PubMed |
| Diabetes Mellitus, Type 2 | Polymorphism of glucokinase gene in non-insulin dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Polymorphisms in genes involved in glucose metabolism in cases of sudden infant death syndrome. | PubMed |
| Diabetes Mellitus, Type 2 | Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians. | PubMed |
| Diabetes Mellitus, Type 2 | Promoter variation in the liver glucokinase is a risk factor for non-insulin-dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Repair of diverse diabetic defects of ?-cells in man and mouse by pharmacological glucokinase activation. | PubMed |
| Diabetes Mellitus, Type 2 | Safety, pharmacokinetics and pharmacodynamics of multiple-ascending doses of the novel glucokinase activator AZD1656 in patients with type 2 diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Screening of mutations and polymorphisms in the glucokinase gene in Czech diabetic and healthy control populations. | PubMed |
| Diabetes Mellitus, Type 2 | Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients. | PubMed |
| Diabetes Mellitus, Type 2 | Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes. | PubMed |
| Diabetes Mellitus, Type 2 | Searching for genes in diabetes and the metabolic syndrome. | PubMed |
| Diabetes Mellitus, Type 2 | Sequence variations of the glucokinase gene in Japanese subjects with NIDDM. | PubMed |
| Diabetes Mellitus, Type 2 | Single-strand conformation polymorphism analysis of the glucose transporter gene GLUT1 in maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique. | PubMed |
| Diabetes Mellitus, Type 2 | Specific insulin and proinsulin secretion in glucokinase-deficient individuals. | PubMed |
| Diabetes Mellitus, Type 2 | Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. | PubMed |
| Diabetes Mellitus, Type 2 | Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2). | PubMed |
| Diabetes Mellitus, Type 2 | Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | The beta cell in NIDDM: giving light to the blind. | PubMed |
| Diabetes Mellitus, Type 2 | The genetic abnormality in the beta cell determines the response to an oral glucose load. | PubMed |
| Diabetes Mellitus, Type 2 | The genetic basis of diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent. | PubMed |
| Diabetes Mellitus, Type 2 | The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells. | PubMed |
| Diabetes Mellitus, Type 2 | The influence of dietary carbohydrate content on glycaemia in patients with glucokinase maturity-onset diabetes of the young. | PubMed |
| Diabetes Mellitus, Type 2 | The pancreatic beta-cell glucose sensor. | PubMed |
| Diabetes Mellitus, Type 2 | Therapy targeting beta-cell survival and function in type 2 diabetes mellitus. | PubMed |
| Diabetes Mellitus, Type 2 | Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online. | PubMed |
| Diabetes Mellitus, Type 2 | Tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator AZD1656, after single ascending doses in healthy subjects during euglycemic clamp. | PubMed |
| Diabetes Mellitus, Type 2 | Type II diabetes: search for primary defects. | PubMed |
| Diabetes Mellitus, Type 2 | Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. | PubMed |
| Diabetes Mellitus, Type 2 | Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme. | PubMed |
| Diabetes Mellitus, Type 2 | [Genetic diagnosis of diabetes mellitus] | PubMed |
| Diabetes Mellitus, Type 2 | [Genetics of type 2 diabetes mellitus: genes implicated in early onset diabetes] | PubMed |
| Diabetes Mellitus, Type 2 | [Genetics of type II diabetes] | PubMed |
| Diabetes Mellitus, Type 2 | [Glucokinase gene abnormalities in maturity-onset diabetes of the young (MODY) and late-onset NIDDM] | PubMed |
| Diabetes Mellitus, Type 2 | [Glucokinase gene mutation as a causative factor of permanent neonatal diabetes mellitus]. | PubMed |
| Diabetes Mellitus, Type 2 | [Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery] | PubMed |
| Diabetes Mellitus, Type 2 | [Heterogeneity in pathogenesis of NIDDM and recent advances in research of diabetogenic genes] | PubMed |
| Diabetes Mellitus, Type 2 | [Maturity-onset diabetes of the young--MODY. Molecular-genetic, pathophysiological and clinical characteristics] | PubMed |
| Diabetes Mellitus, Type 2 | [MODY types of diabetes mellitus] | PubMed |
| Diabetes Mellitus, Type 2 | [MODY, a model of genotype/phenotype interactions in type 2 diabetes] | PubMed |
| Diabetes Mellitus, Type 2 | [Monogenic forms of diabetes mellitus] | PubMed |
| Diabetes Mellitus, Type 2 | [Mutations of glucokinase gene in Japanese subjects with NIDDM] | PubMed |
| Diabetes Mellitus, Type 2 | [NIDDM susceptibility genes] | PubMed |
| Diabetes Mellitus, Type 2 | [Novel glucokinase mutation in a boy with maturity-onset diabetes of the young] | PubMed |
| Diabetes Mellitus, Type 2 | [Pathogenesis of impaired insulin secretion in NIDDM] | PubMed |
| Diabetes Mellitus, Type 2 | [The functional analysis of glucokinase gene E339K mutation]. | PubMed |
| Diabetes, Gestational | A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria. | PubMed |
| Diabetes, Gestational | Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. | PubMed |
| Diabetes, Gestational | Gestational diabetes mellitus and gene mutations which affect insulin secretion. | PubMed |
| Diabetes, Gestational | Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning. | PubMed |
| Diabetes, Gestational | Glucokinase mutations in a phenotypically selected multiethnic group of women with a history of gestational diabetes. | PubMed |
| Diabetes, Gestational | High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population. | PubMed |
| Diabetes, Gestational | Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women. | PubMed |
| Diabetes, Gestational | Identification of glucokinase mutations in subjects with gestational diabetes mellitus. | PubMed |
| Diabetes, Gestational | Influence of maternal and fetal glucokinase mutations in gestational diabetes. | PubMed |
| Diabetes, Gestational | Linkage analysis and molecular scanning of glucokinase gene in NIDDM families. | PubMed |
| Diabetes, Gestational | The glucokinase gene promoter polymorphism -30G>A (rs1799884) is associated with fasting glucose in healthy pregnant women but not with gestational diabetes. | PubMed |
| Diabetes, Gestational | The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent. | PubMed |
| Diabetes, Gestational | Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online. | PubMed |
| Diabetes, Gestational | [Association of glucokinase gene with gestational diabetes mellitus in Chinese] | PubMed |
| Diabetes, Gestational | [Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery] | PubMed |
| Dyslipidemias | Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study. | PubMed |
| Dyslipidemias | Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study. | PubMed |
| Fatty Liver | A glucokinase-like enzyme induced in Mule duck livers by overfeeding. | PubMed |
| Fatty Liver | Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease. | PubMed |
| Fatty Liver | Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans. | PubMed |
| Fatty Liver | Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans. | PubMed |
| Fatty Liver | Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. | PubMed |
| Fetal Growth Retardation | Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance. | PubMed |
| Fetal Growth Retardation | Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway. | PubMed |
| Fetal Growth Retardation | The effect of intrauterine growth restriction upon fetal and postnatal hepatic glucose transporter and glucokinase proteins. | PubMed |
| Genetic Diseases, Inborn | Therapy targeting beta-cell survival and function in type 2 diabetes mellitus. | PubMed |
| glucokinase deficiency | ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes. | PubMed |
| glucokinase deficiency | beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes. | PubMed |
| glucokinase deficiency | Clinical characteristics of mutation carriers in a large family with glucokinase diabetes (MODY2). | PubMed |
| glucokinase deficiency | Complete glucokinase deficiency is not a common cause of permanent neonatal diabetes. | PubMed |
| glucokinase deficiency | Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. | PubMed |
| glucokinase deficiency | Glucokinase deficiency results in a beta-cell disorder characterised by normal fasting plasma proinsulin concentrations. | PubMed |
| glucokinase deficiency | Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation. | PubMed |
| glucokinase deficiency | Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families. | PubMed |
| glucokinase deficiency | Management of neonatal and infancy-onset diabetes mellitus. | PubMed |
| glucokinase deficiency | Neonatal diabetes mellitus due to complete glucokinase deficiency. | PubMed, PubMed |
| glucokinase deficiency | New perspectives on pancreatic islet glucokinase. | PubMed |
| glucokinase deficiency | Permanent neonatal diabetes caused by a homozygous nonsense mutation in the glucokinase gene. | PubMed |
| glucokinase deficiency | Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway. | PubMed |
| glucokinase deficiency | Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique. | PubMed |
| glucokinase deficiency | [Non-insulin dependent diabetes in children and adolescents] | PubMed |
| Glucose Intolerance | Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase. | PubMed |
| Glucose Intolerance | Alterations in key carbohydrate-metabolizing enzyme activities in rat livers following bile duct ligation and its release. | PubMed |
| Glucose Intolerance | Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity-onset diabetes of the young. | PubMed |
| Glucose Intolerance | Fetal programming of perivenous glucose uptake reveals a regulatory mechanism governing hepatic glucose output during refeeding. | PubMed |
| Glucose Intolerance | Glucokinase gene expression is nutritionally regulated in liver of gilthead sea bream (Sparus aurata). | PubMed |
| Glucose Intolerance | Glucokinase gene polymorphisms: a genetic marker for glucose intolerance in a cohort of elderly Finnish men. | PubMed |
| Glucose Intolerance | Glucokinase gene variants in the common form of NIDDM. | PubMed |
| Glucose Intolerance | Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. | PubMed |
| Glucose Intolerance | Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism. | PubMed |
| Glucose Intolerance | Pioglitazone versus metformin in two rat models of glucose intolerance and diabetes. | PubMed |
| Glucose Intolerance | Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians. | PubMed |
| Glucose Intolerance | [Insulin-dependent neonatal and infant diabetes: genetics and physiopathology] | PubMed |
| glycerol-3-phosphate dehydrogenase deficiency | The beta cell in NIDDM: giving light to the blind. | PubMed |
| Glycogen Storage Disease | Pathophysiology of impaired pulsatile insulin release. | PubMed |
| Glycosuria | Improved metabolic disorders of insulin receptor-deficient mice by transgenic overexpression of glucokinase in the liver. | PubMed |
| Glycosuria | Neonatal islet cell transplantation in the diabetic rat: effect on hepatic enzyme activity and glucose homeostasis. | PubMed |
| Gout | Association between gout and polymorphisms in GCKR in male Han Chinese. | PubMed |
| Hypercholesterolemia | Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model. | PubMed |
| Hyperglycemia | A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites. | PubMed |
| Hyperglycemia | A glucokinase-like enzyme carries out glucose phosphorylation in capillaries of normal and spontaneously hyperglycemic rabbits. | PubMed |
| Hyperglycemia | A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. | PubMed |
| Hyperglycemia | Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene. | PubMed |
| Hyperglycemia | Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. | PubMed |
| Hyperglycemia | Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice. | PubMed |
| Hyperglycemia | Antenatal Diagnosis of Fetal Genotype Determines if Maternal Hyperglycemia Due to a Glucokinase Mutation Requires Treatment. | PubMed |
| Hyperglycemia | Autoregulation by glucose of hepatic glucose balance: permissive effect of insulin. | PubMed |
| Hyperglycemia | beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes. | PubMed |
| Hyperglycemia | Biochemical Characterization of MODY2 Glucokinase Variants V62M and G72R Reveals Reduced Enzymatic Activities Relative to Wild-type. | PubMed |
| Hyperglycemia | Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. | PubMed |
| Hyperglycemia | Correction of diabetic alterations by glucokinase. | PubMed |
| Hyperglycemia | Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. | PubMed |
| Hyperglycemia | Dexamethasone increases glucose cycling, but not glucose production, in healthy subjects. | PubMed |
| Hyperglycemia | Energy-dependent intracellular translocation of glucokinase in rat pancreatic islets. | PubMed |
| Hyperglycemia | Exendin-4 activates glucokinase. | PubMed |
| Hyperglycemia | Expression of glucokinase in skeletal muscle: a new approach to counteract diabetic hyperglycemia. | PubMed |
| Hyperglycemia | Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. | PubMed |
| Hyperglycemia | GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. | PubMed |
| Hyperglycemia | Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. | PubMed |
| Hyperglycemia | Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy. | PubMed |
| Hyperglycemia | Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake. | PubMed |
| Hyperglycemia | Glucokinase mutations in young children with hyperglycemia. | PubMed |
| Hyperglycemia | Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase. | PubMed |
| Hyperglycemia | Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. | PubMed |
| Hyperglycemia | Glucose-regulated glucose uptake by transplanted muscle cells expressing glucokinase counteracts diabetic hyperglycemia. | PubMed |
| Hyperglycemia | Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression. | PubMed |
| Hyperglycemia | Hypoglycemic and antioxidative effects of hydroxyethyl methylcellulose in mice fed with high fat diet. | PubMed |
| Hyperglycemia | Impact of Type 2 diabetes on Glucokinase diabetes (GCK-MODY) phenotype in a Roma (Gypsy) family - case report. | PubMed |
| Hyperglycemia | In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents. | PubMed |
| Hyperglycemia | Influence of maternal and fetal glucokinase mutations in gestational diabetes. | PubMed |
| Hyperglycemia | Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. | PubMed |
| Hyperglycemia | Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research. | PubMed |
| Hyperglycemia | Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2). | PubMed |
| Hyperglycemia | Low glucokinase activity and high rates of gluconeogenesis contribute to hyperglycemia in barn owls (Tyto alba) after a glucose challenge. | PubMed |
| Hyperglycemia | Maturity-onset diabetes of the young. | PubMed |
| Hyperglycemia | Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. | PubMed |
| Hyperglycemia | Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus. | PubMed |
| Hyperglycemia | Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes. | PubMed |
| Hyperglycemia | Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway. | PubMed |
| Hyperglycemia | Rabbit lens and retina phosphorylate glucose through a glucokinase-like enzyme: study in normal and spontaneously hyperglycemic animals. | PubMed |
| Hyperglycemia | Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus. | PubMed |
| Hyperglycemia | Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets. | PubMed |
| Hyperglycemia | Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects. | PubMed |
| Hyperglycemia | Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1. | PubMed |
| Hyperglycemia | Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. | PubMed |
| Hyperglycemia | Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle. | PubMed |
| Hyperglycemia | Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique. | PubMed |
| Hyperglycemia | Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia. | PubMed |
| Hyperglycemia | The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent. | PubMed |
| Hyperglycemia | The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. | PubMed |
| Hyperglycemia | The role of hepatic, renal and intestinal gluconeogenic enzymes in glucose homeostasis of juvenile rainbow trout. | PubMed |
| Hyperglycemia | Translocation of glucokinase in pancreatic beta-cells during acute and chronic hyperglycemia. | PubMed |
| Hyperglycemia | Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. | PubMed |
| Hyperglycemia | Who should have genetic testing for MODY? | PubMed |
| Hyperglycemia | Zhenqing recipe improves glucose metabolism and insulin sensitivity by repressing hepatic FOXO1 in type 2 diabetic rats. | PubMed |
| Hyperinsulinism | beta-cell stimulus - secretion coupling defects in rodent models of obesity. | PubMed |
| Hyperinsulinism | Derangement in hepatic enzymes caused by sucrose-drinking and its implication for the development of hyperglycemia in female Wistar fatty rats. | PubMed |
| Hyperinsulinism | Diagnostic difficulties in glucokinase hyperinsulinism. | PubMed |
| Hyperinsulinism | Differential regulation of glucokinase activity in pancreatic islets and liver of the rat. | PubMed |
| Hyperinsulinism | Dominantly inherited hyperinsulinaemic hypoglycaemia. | PubMed |
| Hyperinsulinism | Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice. | PubMed |
| Hyperinsulinism | Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism due to glucokinase activating mutations. | PubMed |
| Hyperinsulinism | Familial hyperinsulinism caused by an activating glucokinase mutation. | PubMed |
| Hyperinsulinism | Family with autosomal dominant hyperinsulinism associated with A456V mutation in the glucokinase gene. | PubMed |
| Hyperinsulinism | Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy. | PubMed |
| Hyperinsulinism | Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake. | PubMed |
| Hyperinsulinism | Hepatic insulin resistance induced by chronic hindlimb ischemia. | PubMed |
| Hyperinsulinism | Homotropic allosteric regulation in monomeric mammalian glucokinase. | PubMed |
| Hyperinsulinism | In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues. | PubMed |
| Hyperinsulinism | Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells. | PubMed |
| Hyperinsulinism | Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1. | PubMed |
| Hyperinsulinism | Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle? | PubMed |
| Hyperinsulinism | The effects of pregnancy steroids on adaptation of beta cells to pregnancy involve the pancreatic glucose sensor glucokinase. | PubMed |
| Hyperinsulinism | The genetics of neonatal hyperinsulinism. | PubMed |
| Hyperlipidemias | Hyperlipemia in the gerbil: effect of diet on serum lipids and hepatic glucokinase. | PubMed |
| Hyperlipidemias | Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. | PubMed |
| Hypersensitivity | Cell specific differences in DNase I hypersensitivity between the two promoters of the rat glucokinase gene. | PubMed |
| Hypersensitivity | Changes induced by sucrose administration on glucose metabolism in pancreatic islets in normal hamsters. | PubMed |
| Hypersensitivity | Induction of the glucokinase gene by insulin in cultured neonatal rat hepatocytes. Relationship with DNase-I hypersensitive sites and functional analysis of a putative insulin-response element. | PubMed |
| Hypertension | G/A Polymorphism at -258 of the Hepatic Glucokinase Promoter Is Not Associated with Decreased Birth Weight in Preterm Neonates. | PubMed |
| Hypertriglyceridemia | Impaired beta-cell function and deposition of fat droplets in the pancreas as a consequence of hypertriglyceridemia in OLETF rat, a model of spontaneous NIDDM. | PubMed |
| Hypertriglyceridemia | Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. | PubMed |
| Hypervitaminosis A | Early effects of vitamin A toxicity on hepatic glycolysis in rat. | PubMed |
| Hypoglycemia | Adaptation of glucokinase gene expression in the rat dorsal vagal complex in a model for recurrent intermediate insulin-induced hypoglycemia: impact of gender. | PubMed |
| Hypoglycemia | Brain glucosamine boosts protective glucoprivic feeding. | PubMed |
| Hypoglycemia | Cell-specific roles of glucokinase in glucose homeostasis. | PubMed |
| Hypoglycemia | Conformational transition pathway in the allosteric process of human glucokinase. | PubMed |
| Hypoglycemia | Counterregulatory responses to hypoglycemia in patients with glucokinase gene mutations. | PubMed |
| Hypoglycemia | Differential regulation of glucokinase activity in pancreatic islets and liver of the rat. | PubMed |
| Hypoglycemia | Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol. | PubMed |
| Hypoglycemia | Effects of caudal hindbrain lactate infusion on insulin-induced hypoglycemia and neuronal substrate transporter glucokinase and sulfonylurea receptor-1 gene expression in the ovariectomized female rat dorsal vagal complex: Impact of estradiol. | PubMed |
| Hypoglycemia | Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism due to glucokinase activating mutations. | PubMed |
| Hypoglycemia | Fructose amplifies counterregulatory responses to hypoglycemia in humans. | PubMed |
| Hypoglycemia | Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy. | PubMed |
| Hypoglycemia | Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken. | PubMed |
| Hypoglycemia | Glucokinase Activators AZD6370 and AZD1656 Do Not Affect the Central Counterregulatory Response to Hypoglycemia in Healthy Males. | PubMed |
| Hypoglycemia | Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression. | PubMed |
| Hypoglycemia | Hyperinsulinism of the newborn. | PubMed |
| Hypoglycemia | Hypoglycemic potential of current and emerging pharmacotherapies in type 2 diabetes mellitus. | PubMed |
| Hypoglycemia | Impact of recurring intermediate insulin-induced hypoglycemia on hypothalamic paraventricular corticotropin-releasing hormone, oxytocin, vasopressin and glucokinase gene profiles: role of type II glucocorticoid receptors. | PubMed |
| Hypoglycemia | Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. | PubMed |
| Hypoglycemia | Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis. | PubMed |
| Hypoglycemia | Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene. | PubMed |
| Hypoglycemia | Quantitative RT-PCR and immunoblot analyses reveal acclimated A2 noradrenergic neuron substrate fuel transporter, glucokinase, phospho-AMPK, and dopamine-?-hydroxylase responses to hypoglycemia. | PubMed |
| Hypoglycemia | Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects. | PubMed |
| Hypoglycemia | Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation. | PubMed |
| Hypoglycemia | Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia. | PubMed |
| Hypoglycemia | The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy. | PubMed |
| Hypoglycemia | Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. | PubMed |
| Hypoglycemia | Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. | PubMed |
| Insulin Resistance | A dominant role for glucose in beta cell compensation of insulin resistance. | PubMed |
| Insulin Resistance | Agonist: the case for insulin resistance as a necessary and sufficient cause of type II diabetes mellitus. | PubMed |
| Insulin Resistance | Assessment of insulin sensitivity in glucokinase-deficient subjects. | PubMed |
| Insulin Resistance | Chronically increased glucose uptake by adipose tissue leads to lactate production and improved insulin sensitivity rather than obesity in the mouse. | PubMed |
| Insulin Resistance | Development and regulation of glucose transporter and hexokinase expression in rat. | PubMed |
| Insulin Resistance | Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect. | PubMed |
| Insulin Resistance | Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. | PubMed |
| Insulin Resistance | G/A Polymorphism at -258 of the Hepatic Glucokinase Promoter Is Not Associated with Decreased Birth Weight in Preterm Neonates. | PubMed |
| Insulin Resistance | Genetics of non-insulin-dependent (type-II) diabetes mellitus. | PubMed |
| Insulin Resistance | Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. | PubMed |
| Insulin Resistance | Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease. | PubMed |
| Insulin Resistance | Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome. | PubMed |
| Insulin Resistance | Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation. | PubMed |
| Insulin Resistance | Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians. | PubMed |
| Insulin Resistance | Hepatic insulin resistance induced by chronic hindlimb ischemia. | PubMed |
| Insulin Resistance | High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP). | PubMed |
| Insulin Resistance | Islet adaptive changes to fructose-induced insulin resistance: beta-cell mass, glucokinase, glucose metabolism, and insulin secretion. | PubMed |
| Insulin Resistance | Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus. | PubMed |
| Insulin Resistance | Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2). | PubMed |
| Insulin Resistance | Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance. | PubMed |
| Insulin Resistance | Maturity-onset diabetes of the young. | PubMed |
| Insulin Resistance | Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells. | PubMed |
| Insulin Resistance | Metabolic syndrome: evidences for a personalized nutrition. | PubMed |
| Insulin Resistance | New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer). | PubMed |
| Insulin Resistance | Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. | PubMed |
| Insulin Resistance | Prevention of obesity and insulin resistance by glucokinase expression in skeletal muscle of transgenic mice. | PubMed |
| Insulin Resistance | Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes. | PubMed |
| Insulin Resistance | Role of glucose-6 phosphatase, glucokinase, and glucose-6 phosphate in liver insulin resistance and its correction by metformin. | PubMed |
| Insulin Resistance | [Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery] | PubMed |
| Insulin Resistance | [Insulin and physical exercise] | PubMed |
| Insulinoma | Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase. | PubMed |
| Insulinoma | An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. | PubMed |
| Insulinoma | Characteristics of glucokinase of the Kirkman insulinoma. | PubMed |
| Insulinoma | Discrimination of glucose anomers by glucokinase from liver and transplantable insulinoma. | PubMed |
| Insulinoma | Effect of retinoic acid on glucokinase activity and gene expression and on insulin secretion in primary cultures of pancreatic islets. | PubMed |
| Insulinoma | Glucagon-like peptide 1 stimulates post-translational activation of glucokinase in pancreatic beta cells. | PubMed |
| Insulinoma | Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization. | PubMed |
| Insulinoma | Glucokinase gene structure. Functional implications of molecular genetic studies. | PubMed |
| Insulinoma | GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. | PubMed |
| Insulinoma | Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells. | PubMed |
| Insulinoma | Identification and significance of glucokinase in transplantable insulinomas. | PubMed |
| Insulinoma | Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell. | PubMed |
| Insulinoma | Insulin secretion, insulin content and glucose phosphorylation in RINm5F insulinoma cells after transfection with human GLUT2 glucose-transporter cDNA. | PubMed |
| Insulinoma | Mannose phosphorylation by glucokinase from liver and transplantable insulinoma. Cooperativity and discrimination of anomers. | PubMed |
| Insulinoma | Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. | PubMed |
| Insulinoma | Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. | PubMed |
| Insulinoma | Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) | PubMed |
| Insulinoma | Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. | PubMed |
| Insulinoma | Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2. | PubMed |
| Insulinoma | Regulation of insulin secretion from novel engineered insulinoma cell lines. | PubMed |
| Lipidoses | Discovery of piragliatin-first glucokinase activator studied in type 2 diabetic patients. | PubMed |
| Liver Cirrhosis | Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. | PubMed |
| Liver Cirrhosis, Biliary | Reduced hepatic glycogen stores in patients with liver cirrhosis. | PubMed |
| Liver Diseases | Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease. | PubMed |
| Liver Diseases | Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. | PubMed |
| Liver Diseases | [Clinical studies on the serum glucokinase activity values. 1. Erythrocyte glucokinase activity values in normal infants and children, in ekiri-like syndrome, in diabetes mellitus, and in liver diseases.] | PubMed |
| Lymphoma, Non-Hodgkin | Intracellular localization of glucokinase and glycolytic enzymes in lymphosarcoma. | PubMed |
| Malnutrition | Onset of carbon catabolite repression in Aspergillus nidulans. Parallel involvement of hexokinase and glucokinase in sugar signaling. | PubMed |
| Malnutrition | Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism. | PubMed |
| Menkes Kinky Hair Syndrome | Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening. | PubMed |
| Metabolic Diseases | Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism. | PubMed |
| Migraine Disorders | Genetic approaches to common diseases. | PubMed |
| Neoplasms | Anti-Diabetic Effect of Trigonelline and Nicotinic Acid, on KK-A(y) Mice. | PubMed |
| Neoplasms | Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice. | PubMed |
| Neoplasms | Cellular and molecular characterization of a feline insulinoma. | PubMed |
| Neoplasms | Characteristics of glucokinase of the Kirkman insulinoma. | PubMed |
| Neoplasms | Defective regulation of glucokinase in rat pancreatic islet cell tumours. | PubMed |
| Neoplasms | Differential regulation of glucokinase activity in pancreatic islets and liver of the rat. | PubMed |
| Neoplasms | Effect of tumors with different growth rates on enzymes in host liver. | PubMed |
| Neoplasms | Evidence for a major gene for type II diabetes and linkage analyses with selected candidate genes in Mexican-Americans. | PubMed |
| Neoplasms | Expression of two type II-like tumor hexokinase RNA transcripts in cancer cell lines. | PubMed |
| Neoplasms | High Km glucose-phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose. | PubMed |
| Neoplasms | Hormonal and dietary regulation of hepatic enzymes in tumor-bearing rats. | PubMed |
| Neoplasms | Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase. | PubMed |
| Neoplasms | The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat. | PubMed |
| Neoplasms | The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells. | PubMed |
| Neoplasms | [Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis] | PubMed |
| Neoplasms | [Hexokinase and glucokinase activity in human and animal tumors] | PubMed |
| Neuroendocrine Tumors | Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. | PubMed |
| Obesity | A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. | PubMed |
| Obesity | Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes. | PubMed |
| Obesity | Clinical characteristics of subjects with a missense mutation in glucokinase. | PubMed |
| Obesity | Constitutive hepatic glucokinase activity in db/db and ob/ob mice. | PubMed |
| Obesity | Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children. | PubMed |
| Obesity | Glucokinase Regulatory Protein (GCKR) Gene rs4425043 Polymorphism is Associated with Overweight and Obesity in Chinese Women. | PubMed |
| Obesity | In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents. | PubMed |
| Obesity | Prevention of obesity and insulin resistance by glucokinase expression in skeletal muscle of transgenic mice. | PubMed |
| Obesity | Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring. | PubMed |
| Obesity | The -30G>A polymorphism of the glucokinase gene promoter is associated with obesity in a population from southern Spain. | PubMed |
| Paralysis | Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase. | PubMed |
| Pituitary Neoplasms | Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: insulin secretion in response to physiological concentrations of glucose. | PubMed |
| Pituitary Neoplasms | D-glucose transport and utilization in pituitary adenoma cells transfected with glucokinase gene. | PubMed |
| Prediabetic State | Characterization of hepatic glucose metabolism disorder with the progress of diabetes in male Spontaneously Diabetic Torii rats. | PubMed |
| Prostatic Neoplasms | A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study). | PubMed |
| Protein Deficiency | The expression of growth-arrest genes in the liver and kidney of the protein-restricted rat fetus. | PubMed |
| Psoriasis | [The skin activity of hexokinase, glucokinase and phosphofructokinase in psoriasis patients] | PubMed |
| Renal Insufficiency, Chronic | Variants of GCKR Affect Both {beta}-Cell and Kidney Function in Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study 2. | PubMed |
| Starvation | Adaptation of glycolytic enzymes: glucose use and insulin release in rat pancreatic islets during fasting and refeeding. | PubMed |
| Starvation | Apparent starvation-induced repression of pancreatic islet glucokinase. | PubMed |
| Starvation | Effect of different thyroid states on rat liver glucokinase synthesis and degradation in vivo. | PubMed |
| Starvation | Effect of thyroid hormones on glucokinase gene transcription in rat liver. | PubMed |
| Starvation | Effects of succinic acid dimethyl ester infusion on metabolic, hormonal, and enzymatic variables in starved rats. | PubMed |
| Starvation | Hepatic glucokinase turnover in intact and adrenalectomized rats in vivo. | PubMed |
| Starvation | Loss of adaptive mechanisms during aging. | PubMed |
| Starvation | Molecular cloning of hepatic glucose-6-phosphatase catalytic subunit from gilthead sea bream (Sparus aurata): response of its mRNA levels and glucokinase expression to refeeding and diet composition. | PubMed |
| Starvation | Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells. | PubMed |
| Starvation | Protective action of succinic acid monomethyl ester against the impairment of glucose-stimulated insulin release caused by glucopenia or starvation: metabolic determinants. | PubMed |
| Starvation | Rapid action of insulin and cyclic AMP in the regulation of functional messenger RNA coding for glucokinase in rat liver. | PubMed |
| Starvation | Reciprocal distribution of hexokinase and glucokinase in the periportal and perivenous zone of the rat liver acinus. | PubMed |
| Starvation | Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells. | PubMed |
| Starvation | Species and tissue distribution of the regulatory protein of glucokinase. | PubMed |
| Starvation | Zonal expression of the glucokinase gene in rat liver. Dynamics during the daily feeding rhythm and starvation-refeeding cycle demonstrated by in situ hybridization. | PubMed |
| Stroke | Functional Variants of Glucokinase Regulatory Protein and Apolipoprotein A5 Genes in Ischemic Stroke. | PubMed |
| Tuberculosis | Cg2091 encodes a polyphosphate/ATP-dependent glucokinase of Corynebacterium glutamicum. | PubMed |
| Tuberculosis | Involvement of tryptophan(s) at the active site of polyphosphate/ATP glucokinase from Mycobacterium tuberculosis. | PubMed |
| Tuberculosis | Purification of polyphosphate and ATP glucose phosphotransferase from Mycobacterium tuberculosis H37Ra: evidence that poly(P) and ATP glucokinase activities are catalyzed by the same enzyme. | PubMed |
| Warm Ischemia | Changes in glucose transporter 2 and carbohydrate-metabolizing enzymes in the liver during cold preservation and warm ischemia. | PubMed |
| Whooping Cough | Bordetella pertussis extract induces increase in the activities of glycolytic enzymes in mouse liver. | PubMed |
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