Ontology explorer

Gene ontology

Change ontology: Version 2014-12-22

Term or Synonym: use AND (NOT) or OR

Definition: use AND (NOT) or OR

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Localization

Enzyme

Details for ureidoglycolate lyase activity

4.3.2.3

Gene ontology ID

GO:0050385

Definition

Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea

Comment

Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19 ; GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3 ; GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.

Synonyms

1. (S)-ureidoglycolate urea-lyase (glyoxylate-forming)
2. (S)-ureidoglycolate urea-lyase activity
3. ureidoglycolase activity
4. ureidoglycolatase activity
5. ureidoglycolate hydrolase activity

References

1. EC 4.3.2.3
2. RHEA: 11304
3. KEGG REACTION: R00776
4. MetaCyc UREIDOGLYCOLATE-LYASE-RXN

Legend

is an element of the parent element

is a part of the parent element

is related to the parent element

derives from the parent element

at least 1 tissue/ enzyme/ localization link in this branch

tissue/ enzyme/ localization link to BRENDA

Condensed Tree View

Gene ontology

molecular_function is a

catalytic activity is a

lyase activity is a

carbon-nitrogen lyase activity is a

amidine-lyase activity is a

ureidoglycolate lyase activity is a

Tree view

Gene ontology

biological_process is a

cellular_component is a

molecular_function is a

binding

catalytic activity is a

catalytic activity, acting on a protein is a

catalytic activity, acting on DNA is a

catalytic activity, acting on RNA is a

cyclase activity is a

hydrolase activity is a

isomerase activity is a

ligase activity is a

lyase activity is a

2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity is a

alkylmercury lyase activity is a

carbon phosphorus lyase activity is a

carbon-carbon lyase activity is a

carbon-halide lyase activity is a

carbon-nitrogen lyase activity is a

amidine-lyase activity is a

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity is a

argininosuccinate lyase activity is a

gamma-glutamylaminecyclotransferase activity is a

gamma-glutamylcyclotransferase activity is a

glutathione specific gamma-glutamylcyclotransferase activity is a

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity is a

ureidoglycolate lyase activity is a

amine-lyase activity is a

ammonia-lyase activity is a

cyanate hydratase activity is a

carbon-oxygen lyase activity is a

carbon-sulfur lyase activity is a

cobalt-precorrin-5A acetaldehyde-lyase activity is a

ferrochelatase activity is a

indoleacetaldoxime dehydratase activity is a

phosphorus-oxygen lyase activity is a

sirohydrochlorin cobaltochelatase activity is a

peptidoglycan muralytic activity is a

transferase activity is a

molecular transducer activity is a

nutrient reservoir activity is a

protein tag is a

small molecule sensor activity is a

structural molecule activity is a

transcription regulator activity is a

transporter activity is a