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Gene ontology
Version 2014-12-22
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Details for saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
1.5.1.8
Gene ontology ID
GO:0047130
Definition
Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH
Synonyms
1. 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
2. L-lysine-alpha-ketoglutarate reductase activity
3. lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)
4. N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
5. saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity
References
1. EC 1.5.1.8
2. RHEA: 19373
3. KEGG REACTION: R00716
4. MetaCyc 1.5.1.8-RXN
5. Reactome: R-HSA-70938 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O"
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