2.5.1.60Gene ontology ID
GO:0004663
Definition
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family
Synonyms
1. geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2. GGTase-II activity
3. GGTaseII activity
4. protein geranylgeranyltransferase type II activity
5. Rab-protein geranylgeranyltransferase activity
6. RabGGTase activity
7. type II protein geranyl-geranyltransferase activity
References
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is a part of the parent element
is related to the parent element
derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA