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Gene ontology
Version 2014-12-22
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Details for hydroxymethylglutaryl-CoA lyase activity
4.1.3.4
Gene ontology ID
GO:0004419
Definition
Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
Synonyms
1. (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
2. (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity
3. 3-hydroxy-3-methylglutarate-CoA lyase activity
4. 3-hydroxy-3-methylglutaryl CoA cleaving enzyme
5. 3-hydroxy-3-methylglutaryl coenzyme A lyase activity
6. 3-hydroxy-3-methylglutaryl-CoA lyase activity
7. HMG-CoA lyase activity
8. hydroxymethylglutaryl coenzyme A lyase activity
9. hydroxymethylglutaryl coenzyme A-cleaving enzyme
References
1. EC 4.1.3.4
2. RHEA: 24404
3. KEGG REACTION: R01360
4. MetaCyc HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
5. Reactome: R-HSA-6788597 "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA"
6. Reactome: R-HSA-74180 "HMG CoA => acetoacetic acid + acetyl CoA"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
lyase activity is a
carbon-carbon lyase activity is a
oxo-acid-lyase activity is a
hydroxymethylglutaryl-CoA lyase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity is a
alkylmercury lyase activity is a
carbon phosphorus lyase activity is a
carbon-carbon lyase activity is a
(1-methylpentyl)succinate synthase activity is a
2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity is a
3,4-dihydroxy-2-butanone-4-phosphate synthase activity is a
aldehyde decarbonylase activity is a
aldehyde oxygenase (deformylating) activity is a
aldehyde-lyase activity is a
benzylsuccinate synthase activity is a
carboxy-lyase activity is a
GTP 3',8'-cyclase activity is a
oxo-acid-lyase activity is a
(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity is a
(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity is a
(4S)-4-hydroxy-2-oxoglutarate aldolase activity is a
(R)-citramalyl-CoA lyase activity is a
(S)-citramalyl-CoA lyase activity is a
1,4-dihydroxy-2-naphthoyl-CoA synthase activity is a
2,3-dimethylmalate lyase activity is a
3-hydroxy-3-isohexenylglutaryl-CoA lyase activity is a
3-hydroxyaspartate aldolase activity is a
4-amino-4-deoxychorismate lyase activity is a
4-hydroxy-2-oxovalerate aldolase activity is a
4-hydroxy-4-methyl-2-oxoglutarate aldolase activity is a
5-chloro-4-hydroxy-2-oxopentanate aldolase activity is a
anthranilate synthase activity is a
chorismate lyase activity is a
cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity is a
citramalate lyase activity is a
citrate (pro-3S)-lyase activity is a
citryl-CoA lyase activity is a
hydroxymethylglutaryl-CoA lyase activity is a
isocitrate lyase activity is a
L-erythro-3-methylmalyl-CoA lyase activity is a
malyl-CoA lyase activity is a
methylisocitrate lyase activity is a
N-acetylneuraminate lyase activity is a
oxalomalate lyase activity is a
straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity is a
tyrosine phenol-lyase activity is a
carbon-halide lyase activity is a
carbon-nitrogen lyase activity is a
carbon-oxygen lyase activity is a
carbon-sulfur lyase activity is a
cobalt-precorrin-5A acetaldehyde-lyase activity is a
ferrochelatase activity is a
indoleacetaldoxime dehydratase activity is a
phosphorus-oxygen lyase activity is a
sirohydrochlorin cobaltochelatase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a