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Gene ontology
Version 2014-12-22
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Details for tetrahydrofolylpolyglutamate synthase activity
6.3.2.17
Gene ontology ID
GO:0004326
Definition
Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)
Synonyms
1. folate polyglutamate synthetase activity
2. folylpoly(gamma-glutamate) synthase activity
3. folylpoly-gamma-glutamate synthase activity
4. folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
5. folylpolyglutamate synthase activity
6. folylpolyglutamate synthetase activity
7. folylpolyglutamyl synthetase activity
8. formyltetrahydropteroyldiglutamate synthetase activity
9. FPGS activity
10. N(10)-formyltetrahydropteroyldiglutamate synthetase activity
11. N10-formyltetrahydropteroyldiglutamate synthetase activity
12. tetrahydrofolate synthase activity
13. tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
14. tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
15. tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
References
1. EC 6.3.2.17
2. MetaCyc FOLYLPOLYGLUTAMATESYNTH-RXN
3. Reactome: R-HSA-197958 "Conversion of cytosolic THF to THF-polyglutamate"
4. Reactome: R-HSA-200681 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate"
5. Reactome: R-HSA-200682 "Conversion of mitochondrial THF to THF-polyglutamate"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
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Condensed Tree View
Gene ontology
biological_process is a
cellular process is a
cellular metabolic process is a
cellular aromatic compound metabolic process is a
aromatic compound biosynthetic process is a
pteridine-containing compound biosynthetic process is a
folic acid-containing compound biosynthetic process is a
tetrahydrofolylpolyglutamate biosynthetic process is a
tetrahydrofolylpolyglutamate synthase activity part of
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
actin filament-based process is a
cell activation is a
cell adhesion molecule production is a
cell aggregation is a
cell communication is a
cell cycle is a
cell death is a
cell division is a
cell growth is a
cell killing is a
cell population proliferation is a
cell recognition is a
cell wall organization or biogenesis is a
cell-cell fusion is a
cellular component organization or biogenesis is a
cellular detoxification is a
cellular developmental process is a
cellular localization is a
cellular metabolic process is a
bioluminescence is a
cellular alcohol metabolic process is a
cellular aldehyde metabolic process is a
cellular alkane metabolic process is a
cellular alkene metabolic process is a
cellular alkyne metabolic process is a
cellular aromatic compound metabolic process is a
(+)-kotanin metabolic process is a
2,5-dihydroxypyridine metabolic process is a
3-(3-hydroxy)phenylpropionate metabolic process is a
3-methylquinoline metabolic process is a
5-methylcytosine metabolic process is a
aromatic amino acid family metabolic process is a
aromatic compound biosynthetic process is a
(R)-mandelate catabolic process to benzoate is a
aromatic primary alcohol biosynthetic process is a
benzene biosynthetic process is a
cocaine biosynthetic process is a
cytosine biosynthetic process is a
daunorubicin biosynthetic process is a
demethylkotanin biosynthetic process is a
epothilone biosynthetic process is a
indole-containing compound biosynthetic process is a
isoquinoline alkaloid biosynthetic process is a
kynurenic acid biosynthetic process is a
mandelate biosynthetic process is a
naphthalene biosynthetic process is a
nicotinate biosynthetic process is a
nitrobenzene biosynthetic process is a
nucleobase-containing compound biosynthetic process is a
ommochrome biosynthetic process is a
orlandin biosynthetic process is a
p-cumate biosynthetic process is a
phenazine biosynthetic process is a
phenol-containing compound biosynthetic process is a
phenylpropanoid biosynthetic process is a
picolinic acid biosynthetic process is a
pteridine-containing compound biosynthetic process is a
7,8-dihydroneopterin 3'-triphosphate biosynthetic process is a
folic acid-containing compound biosynthetic process is a
dihydrofolate biosynthetic process is a
folic acid biosynthetic process is a
tetrahydrofolate biosynthetic process is a
tetrahydrofolylpolyglutamate biosynthetic process is a
tetrahydrofolylpolyglutamate synthase activity part of
methanopterin-containing compound biosynthetic process is a
pteridine biosynthetic process is a
tatiopterin biosynthetic process is a
tetrahydrobiopterin biosynthetic process is a
purine-containing compound biosynthetic process is a
pyridine biosynthetic process is a
pyridoxine biosynthetic process is a
sterigmatocystin biosynthetic process is a
stilbene biosynthetic process is a
tetrapyrrole biosynthetic process is a
thiamine diphosphate biosynthetic process is a
thiamine-containing compound biosynthetic process is a
thiazole biosynthetic process is a
toluene biosynthetic process is a
verruculogen biosynthetic process is a
vibriobactin biosynthetic process is a
aromatic compound catabolic process is a
aromatic primary alcohol metabolic process is a
benzene-containing compound metabolic process is a
carbazole metabolic process is a
cocaine metabolic process is a
coniferin metabolic process is a
daunorubicin metabolic process is a
demethylkotanin metabolic process is a
dibenzo-p-dioxin metabolic process is a
dibenzofuran metabolic process is a
doxorubicin metabolic process is a
epothilone metabolic process is a
fluorene metabolic process is a
imidazole-containing compound metabolic process is a
indole-containing compound metabolic process is a
isoquinoline alkaloid metabolic process is a
kynurenic acid metabolic process is a
naphthalene-containing compound metabolic process is a
nicotinate metabolic process is a
nucleobase-containing compound metabolic process is a
ommochrome metabolic process is a
orlandin metabolic process is a
phenanthrene metabolic process is a
phenol-containing compound metabolic process is a
phenylpropanoid metabolic process is a
picolinic acid metabolic process is a
pteridine-containing compound metabolic process is a
purine-containing compound metabolic process is a
pyridine metabolic process is a
pyridoxamine metabolic process is a
pyridoxine metabolic process is a
s-triazine compound metabolic process is a
sterigmatocystin metabolic process is a
stilbene metabolic process is a
tetrapyrrole metabolic process is a
thiamine diphosphate metabolic process is a
thiamine-containing compound metabolic process is a
thiazole metabolic process is a
verruculogen metabolic process is a
vibriobactin metabolic process is a
cellular biosynthetic process is a
cellular carbohydrate metabolic process is a
cellular catabolic process is a
cellular ketone body metabolic process is a
cellular ketone metabolic process is a
cellular lipid metabolic process is a
cellular macromolecule metabolic process is a
cellular metabolic compound salvage is a
cellular modified amino acid metabolic process is a
cellular nitrogen compound metabolic process is a
cellular organohalogen metabolic process is a
chemosynthesis is a
cofactor metabolic process is a
drug metabolic process is a
generation of precursor metabolites and energy is a
heterocycle metabolic process is a
hydroperoxide metabolic process is a
metabolite repair is a
mucilage metabolic process is a
one-carbon metabolic process is a
organic acid metabolic process is a
organometal metabolic process is a
phosphorus metabolic process is a
photosynthesis is a
prenylation is a
reactive oxygen species metabolic process is a
selenium compound metabolic process is a
sulfur compound metabolic process is a
toxin metabolic process is a
xenobiotic metabolic process is a
cellular pigmentation is a
cellular process involved in reproduction in multicellular organism is a
cellular response to stimulus is a
chromosome segregation is a
cytolysis is a
DNA clamp unloading is a
ensheathment of neurons is a
establishment or maintenance of cell polarity is a
establishment or maintenance of cell type involved in phenotypic switching is a
export from cell is a
intercellular transport is a
intermediate filament-based process is a
light absorption is a
localization of cell is a
membrane docking is a
microtubule organizing center localization is a
microtubule-based process is a
movement of cell or subcellular component is a
multi-organism cellular process is a
phenotypic switching is a
plasmid maintenance is a
process utilizing autophagic mechanism is a
protein folding is a
protein unfolding is a
RNA folding is a
signaling receptor ligand precursor processing is a
stomatal movement is a
syncytium formation is a
transmembrane transport is a
transposition is a
vacuolar transport is a
vesicle-mediated transport is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a