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Gene ontology
Version 2014-12-22
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Details for DNA-(apurinic or apyrimidinic site) endonuclease activity
Gene ontology ID
GO:0003906
Definition
Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)
Synonyms
1. abasic deoxyendoribonuclease activity
2. AP deoxyendoribonuclease activity
3. apurinic deoxyendoribonuclease activity
4. apurinic/apyrimidinic endodeoxyribonuclease activity
5. apyrimidinic deoxyendoribonuclease activity
6. deoxyribonuclease (apurinic or apyrimidinic) activity
7. endonuclease VIII activity
8. UV endonuclease
References
1. Wikipedia: AP endonuclease
2. Reactome: R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break"
3. Reactome: R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site"
4. Reactome: R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)"
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Gene ontology