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Gene ontology
Version 2014-12-22
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Details for 3-keto sterol reductase activity
1.1.1.270
Gene ontology ID
GO:0000253
Definition
Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+)
Comment
Note that zymosterol is cholesta-8,24-dien-3-ol.
Synonyms
1. 3-keto-steroid reductase activity
2. 3-KSR activity
3. 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
References
1. EC 1.1.1.270
2. GOC: mah
3. MetaCyc 1.1.1.270-RXN
4. MetaCyc RXN3O-4110
5. MetaCyc RXN66-19
6. MetaCyc RXN66-24
7. MetaCyc RXN66-314
8. MetaCyc RXN66-319
9. PMID 9811880
10. Reactome: R-HSA-194632 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)"
11. Reactome: R-HSA-194689 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol"
12. RHEA: 18409
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