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Literature summary extracted from
- Characterization of a filtrable 3'-nucleotidase of Leishmania donovani (1993), Biochim. Biophys. Acta, 1203, 162-167.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.6 | 2'-deoxyadenosine 3'-phosphate | - |
Leishmania donovani |  |
| 3.1.3.6 | 5'-AMP | - |
Leishmania donovani | |
| 3.1.3.6 | ADP | - |
Leishmania donovani | |
| 3.1.3.6 | ATP | - |
Leishmania donovani | |
| 3.1.3.6 | EDTA | - |
Leishmania donovani | |
| 3.1.3.6 | p-hydroxymercuribenzoate | - |
Leishmania donovani | |
| 3.1.3.6 | Sodium citrate | - |
Leishmania donovani | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.3.6 | 0.32 | - |
3'-AMP | - |
Leishmania donovani | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.6 | plasma membrane | 55% on the outer surface and the remaining activity presumably on the inside of the plasma membrane | Leishmania donovani | 5886 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.6 | Leishmania donovani | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.3.6 | - |
Leishmania donovani |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.6 | 3'-AMP + H2O | 92% of the activity with 3'-IMP | Leishmania donovani | adenosine + phosphate | - |
? | |
| 3.1.3.6 | 3'-CMP + H2O | 8% of the activity with 3'-IMP | Leishmania donovani | cytosine + phosphate | - |
? | |
| 3.1.3.6 | 3'-GMP + H2O | 24% of the activity with 3'-IMP | Leishmania donovani | guanosine + phosphate | - |
? | |
| 3.1.3.6 | 3'-IMP + H2O | best substrate | Leishmania donovani | inosine + phosphate | - |
? | |
| 3.1.3.6 | 3'-UMP + H2O | 59% of the activity with 3'-IMP | Leishmania donovani | uridine + phosphate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.6 | 7.5 | - |
activity of the inside of the plasma membrane | Leishmania donovani |
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Release 2023.1 (January 2023)
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