Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Garvey, E.P.; Lowen, G.T.; Almond, M.R.
    Nucleotide and nucleoside analogues as inhibitors of cytosolic 5'-nucleotidase I from heart (1998), Biochemistry, 37, 9043-9051.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.5 pharmacology inhibitors could be used to diminish nucleotide depletion during ischemia/reperfusion Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.5 (2R,4S,5R)-1-[5-(2-fluoro-2-phosphonoethyl)tetrahydro-4-hydroxy-2-furyl]thymine
-
 Oryctolagus cuniculus
3.1.3.5 (2R,4S,5R)-1-[tetrahydro-4-hydroxy-5-(2-phosphonoethyl)-2-furyl]thymine
-
 Oryctolagus cuniculus
3.1.3.5 (2R,5R)-1-[5-(2-fluoro-2-phosphonoethyl)tetrahydro-2-furyl]thymine
-
 Oryctolagus cuniculus
3.1.3.5 (2R,5S)-1-[tetrahydro-5-(2-phosphonoethyl)-2-furyl]thymine
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.5 0.02
-
 5'-TMP cytosolic enzyme c-N-I Oryctolagus cuniculus
3.1.3.5 0.061
-
 5'-dCMP cytosolic enzyme c-N-I Oryctolagus cuniculus
3.1.3.5 0.11
-
 5'-CMP cytosolic enzyme c-N-I Oryctolagus cuniculus
3.1.3.5 0.13
-
 5'-dAMP cytosolic enzyme c-N-I Oryctolagus cuniculus
3.1.3.5 0.32
-
 5'-GMP cytosolic enzyme c-N-I Oryctolagus cuniculus
3.1.3.5 1
-
 5'-IMP cytosolic enzyme c-N-I Oryctolagus cuniculus
3.1.3.5 1.2
-
 5'-AMP cytosolic enzyme c-N-I Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.5 cytosol
-
 Oryctolagus cuniculus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.5 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.5 heart
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.5 10
-
 enzyme e-N Oryctolagus cuniculus
3.1.3.5 71
-
 enzyme c-N-I Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.5 5'-AMP + H2O
-
 Oryctolagus cuniculus adenosine + phosphate
-
 ?
3.1.3.5 5'-CMP + H2O
-
 Oryctolagus cuniculus cytidine + phosphate
-
 ?
3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Oryctolagus cuniculus deoxyadenosine + phosphate
-
 ?
3.1.3.5 5'-dCMP + H2O i.e. 2'-deoxycytosine 5'-phosphate Oryctolagus cuniculus deoxycytidine + phosphate
-
 ?
3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Oryctolagus cuniculus deoxyguanosine + phosphate
-
 ?
3.1.3.5 5'-GMP + H2O
-
 Oryctolagus cuniculus guanosine + phosphate
-
 ?
3.1.3.5 5'-IMP + H2O
-
 Oryctolagus cuniculus inosine + phosphate
-
 ?
3.1.3.5 5'-TMP + H2O
-
 Oryctolagus cuniculus thymidine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.5 c-N-II
-
 Oryctolagus cuniculus
3.1.3.5 cN-I
-
 Oryctolagus cuniculus
3.1.3.5 e-N
-
 Oryctolagus cuniculus