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Literature summary extracted from

  • Erdös, E.G.; Skidgel, R.A.
    Structure and functions of human angiotensin I converting enzyme (kininase II) (1985), Biochem. Soc. Trans., 13, 42-44.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.15.1 0.0004
-
 bradykinin
-
 Homo sapiens
3.4.15.1 0.002
-
 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met
-
 Homo sapiens
3.4.15.1 0.014
-
 neurotensin
-
 Homo sapiens
3.4.15.1 0.025
-
 Substance P
-
 Homo sapiens
3.4.15.1 1
-
 Leu5-enkephalin
-
 Homo sapiens
3.4.15.1 1
-
 Met5-enkephalin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 2-aminobenzoyl-Ala-Ala-Leu-Ala-Gly-nitrobenzylamide + H2O
-
 Homo sapiens ?
-
 ?
3.4.15.1 2-aminobenzoyl-Ala-Ala-Tyr-Leu-Ala-Gly-nitrobenzylamide + H2O
-
 Homo sapiens ?
-
 ?
3.4.15.1 2-aminobenzoyl-Ala-Tyr-Leu-Ala-Gly-nitrobenzylamide + H2O
-
 Homo sapiens ?
-
 ?
3.4.15.1 2-aminobenzoyl-Val-Tyr-Leu-Ala-Gly-nitrobenzylamide + H2O
-
 Homo sapiens ?
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
3.4.15.1 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met + H2O
-
 Homo sapiens Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + Leu-Met
-
 ?
3.4.15.1 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
 Homo sapiens Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + Leu-Met-NH2
-
 ?
3.4.15.1 bradykinin + H2O
-
 Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
3.4.15.1 Leu5-enkephalin + H2O
-
 Homo sapiens Tyr-Gly-Gly + Phe-Leu
-
 ?
3.4.15.1 Met5-enkephalin + H2O
-
 Homo sapiens Tyr-Gly-Gly + Phe-Met
-
 ?
3.4.15.1 neurotensin + H2O
-
 Homo sapiens pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr + Ile-Leu
-
 ?
3.4.15.1 Substance P + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.15.1 0.567
-
 neurotensin
-
 Homo sapiens
3.4.15.1 3.75
-
 Substance P
-
 Homo sapiens
3.4.15.1 8.33
-
 bradykinin
-
 Homo sapiens
3.4.15.1 8.33
-
 angiotensin
-
 Homo sapiens
3.4.15.1 11.7
-
 Leu5-enkephalin
-
 Homo sapiens
3.4.15.1 58.3
-
 Met5-enkephalin
-
 Homo sapiens