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Literature summary extracted from

  • Sooman, L.; Oliw, E.H.
    Discovery of a novel linoleate dioxygenase of Fusarium oxysporum and linoleate diol synthase of Colletotrichum graminicola (2015), Lipids, 50, 1243-1252 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.60 gene GLRG_10013, phylogenetic analysis Colletotrichum graminicola

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.60 linoleate Colletotrichum graminicola
-
(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
-
r
1.13.11.60 additional information Colletotrichum graminicola the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid ?
-
?
1.13.11.60 additional information Colletotrichum graminicola M1.001 the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid ?
-
?
1.13.11.60 additional information Colletotrichum graminicola M1.001 / M2 / FGSC 10212 the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid ?
-
?
1.13.11.60 oleate + O2 Colletotrichum graminicola
-
(9Z)-7,8-dihydroxyoctadeca-9-enoic acid
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.60 Colletotrichum graminicola E3QVI1
-
-
1.13.11.60 Colletotrichum graminicola M1.001 E3QVI1
-
-
1.13.11.60 Colletotrichum graminicola M1.001 / M2 / FGSC 10212 E3QVI1
-
-
1.13.11.60 Fusarium oxysporum F9FU71
-
-
1.13.11.60 Fusarium oxysporum Fo5176 F9FU71
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.60 (R)-8-hydroperoxy-(9Z,12Z)-octadecadienoate + O2
-
Colletotrichum graminicola (8R,11R)-8,11-dihydroperoxy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydroperoxy-(9Z,12Z)-octadecadienoate
-
?
1.13.11.60 (R)-8-hydroperoxy-(9Z,12Z)-octadecadienoate + O2
-
Colletotrichum graminicola M1.001 (8R,11R)-8,11-dihydroperoxy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydroperoxy-(9Z,12Z)-octadecadienoate
-
?
1.13.11.60 (R)-8-hydroperoxy-(9Z,12Z)-octadecadienoate + O2
-
Colletotrichum graminicola M1.001 / M2 / FGSC 10212 (8R,11R)-8,11-dihydroperoxy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydroperoxy-(9Z,12Z)-octadecadienoate
-
?
1.13.11.60 alpha-linolenic acid + O2
-
Colletotrichum graminicola ?
-
?
1.13.11.60 alpha-linolenic acid + O2
-
Colletotrichum graminicola M1.001 ?
-
?
1.13.11.60 alpha-linolenic acid + O2
-
Colletotrichum graminicola M1.001 / M2 / FGSC 10212 ?
-
?
1.13.11.60 arachidonic acid + O2
-
Fusarium oxysporum (R)-10-hydroxyarachidonic acid
-
?
1.13.11.60 arachidonic acid + O2
-
Fusarium oxysporum Fo5176 (R)-10-hydroxyarachidonic acid
-
?
1.13.11.60 docosapentaenoic acid + O2
-
Fusarium oxysporum (R)-10-hydroperoxy-docosapentaenoic acid
-
?
1.13.11.60 docosapentaenoic acid + O2
-
Fusarium oxysporum Fo5176 (R)-10-hydroperoxy-docosapentaenoic acid
-
?
1.13.11.60 gamma-linolenic acid + O2
-
Fusarium oxysporum (R)-8-hydroxy-gamma-linolenic acid
-
?
1.13.11.60 gamma-linolenic acid + O2
-
Fusarium oxysporum Fo5176 (R)-8-hydroxy-gamma-linolenic acid
-
?
1.13.11.60 linoleate
-
Colletotrichum graminicola (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
-
r
1.13.11.60 linoleate + O2
-
Colletotrichum graminicola (R)-8-hydroperoxy-(9Z,12Z)-octadecadienoate + (8R,11R)-8,11-dihydroperoxy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydroperoxy-(9Z,12Z)-octadecadienoate
-
?
1.13.11.60 linoleate + O2
-
Fusarium oxysporum (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoic acid
-
?
1.13.11.60 linoleate + O2
-
Fusarium oxysporum Fo5176 (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoic acid
-
?
1.13.11.60 additional information enzyme metabolizes fatty acids to hydroperoxides with broad substrate specificity. Products show R configuration at the (n-10) positions. Fatty acids of the n-3 series are oxidized less efficiently and often to hydroperoxides with an R configuration at both (n-10) and (n-7) positions Fusarium oxysporum ?
-
?
1.13.11.60 additional information enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid Colletotrichum graminicola ?
-
?
1.13.11.60 additional information no substrate: gamma-linolenoate Colletotrichum graminicola ?
-
?
1.13.11.60 additional information the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid Colletotrichum graminicola ?
-
?
1.13.11.60 additional information enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid Colletotrichum graminicola M1.001 ?
-
?
1.13.11.60 additional information no substrate: gamma-linolenoate Colletotrichum graminicola M1.001 ?
-
?
1.13.11.60 additional information the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid Colletotrichum graminicola M1.001 ?
-
?
1.13.11.60 additional information enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid Colletotrichum graminicola M1.001 / M2 / FGSC 10212 ?
-
?
1.13.11.60 additional information no substrate: gamma-linolenoate Colletotrichum graminicola M1.001 / M2 / FGSC 10212 ?
-
?
1.13.11.60 additional information the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid Colletotrichum graminicola M1.001 / M2 / FGSC 10212 ?
-
?
1.13.11.60 additional information enzyme metabolizes fatty acids to hydroperoxides with broad substrate specificity. Products show R configuration at the (n-10) positions. Fatty acids of the n-3 series are oxidized less efficiently and often to hydroperoxides with an R configuration at both (n-10) and (n-7) positions Fusarium oxysporum Fo5176 ?
-
?
1.13.11.60 oleate + O2
-
Colletotrichum graminicola 8-hydroperoxyoctadecamonoenoate + 7,8-dihydroxyoctadecamonoenoate
-
?
1.13.11.60 oleate + O2
-
Colletotrichum graminicola (9Z)-7,8-dihydroxyoctadeca-9-enoic acid
-
?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.60 dioxygenase-cytochrome P450
-
Colletotrichum graminicola
1.13.11.60 DOX-CYP
-
Colletotrichum graminicola
1.13.11.60 FOXB_09952
-
Fusarium oxysporum
1.13.11.60 GLRG_10013
-
Colletotrichum graminicola
1.13.11.60 linoleate 7,8-LDS
-
Colletotrichum graminicola
1.13.11.60 linoleate 8,11-LDS
-
Colletotrichum graminicola
1.13.11.60 linoleate diol synthase
-
Colletotrichum graminicola
1.13.11.60 orphan DOX-CYP
-
Colletotrichum graminicola

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.60
-
-
assay at Fusarium oxysporum
1.13.11.60
-
-
assay at Colletotrichum graminicola

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.13.11.60 additional information
-
incubation at room temperature augments the non-enzymatic formation of epoxy alcohols Fusarium oxysporum
1.13.11.60 additional information
-
incubation at room temperature augments the non-enzymatic formation of epoxy alcohols Colletotrichum graminicola

General Information

EC Number General Information Comment Organism
1.13.11.60 evolution homologue dioxygenase-cytochrome P450 (DOX-CYP) is a fusion protein of the animal heme peroxidase (cyclooxygenase) superfamily. Phylogenetic tree of fungal fusion enzymes with homology to the animal heme peroxidase and CYP superfamilies, overview Colletotrichum graminicola
1.13.11.60 metabolism fungal oxylipins can be formed by two subfamilies of cyclooxygenase-related DOX. The enzymatic activities of the DOX-CYP homologue of Colletotrichum graminicola and the DOX homologue of Fusarium oxysporum. The former oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid. The latter metabolizes fatty acids to hydroperoxides with broad substrate specificity. It oxidizes 20:4n-6 and 18:2n-6 to hydroperoxides with an R configuration at the (n-10) positions, and other n-6 fatty acids in the same way Colletotrichum graminicola