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Literature summary extracted from

  • Hoering, P.; Rothschild-Mancinelli, K.; Sharma, N.; Boyd, D.; Allen, C.
    Oxidative biotransformations of phenol substrates catalysed by toluene dioxygenase A molecular docking study (2016), J. Mol. Catal. B, 134, 396-406 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.12.11 toluene + NADH + H+ + O2 Pseudomonas putida
-
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
?
1.14.12.11 toluene + NADH + H+ + O2 Pseudomonas putida UV4
-
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.12.11 Pseudomonas putida
-
-
-
1.14.12.11 Pseudomonas putida UV4
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.12.11 2-cresol + NADH + H+ + O2 poor substrate Pseudomonas putida (1S,2R)-3-methylcyclohexa-3,5-diene-1,2,4-triol + (2R)-6-methylcyclohexa-3,5-diene-1,1,2-triol + NAD+
-
?
1.14.12.11 2-cresol + NADH + H+ + O2 poor substrate Pseudomonas putida UV4 (1S,2R)-3-methylcyclohexa-3,5-diene-1,2,4-triol + (2R)-6-methylcyclohexa-3,5-diene-1,1,2-triol + NAD+
-
?
1.14.12.11 3-cresol + NADH + H+ + O2
-
Pseudomonas putida (1R,2S)-6-methylcyclohexa-3,5-diene-1,2,4-triol + (2S)-3-methylcyclohexa-3,5-diene-1,1,2-triol + NAD+
-
?
1.14.12.11 3-cresol + NADH + H+ + O2
-
Pseudomonas putida UV4 (1R,2S)-6-methylcyclohexa-3,5-diene-1,2,4-triol + (2S)-3-methylcyclohexa-3,5-diene-1,1,2-triol + NAD+
-
?
1.14.12.11 3-methoxyphenol + NADH + H+ + O2
-
Pseudomonas putida (1S,2S)-6-methoxycyclohexa-3,5-diene-1,2,4-triol + (2S)-3-methoxycyclohexa-3,5-diene-1,1,2-triol + NAD+
-
?
1.14.12.11 3-methoxyphenol + NADH + H+ + O2
-
Pseudomonas putida UV4 (1S,2S)-6-methoxycyclohexa-3,5-diene-1,2,4-triol + (2S)-3-methoxycyclohexa-3,5-diene-1,1,2-triol + NAD+
-
?
1.14.12.11 3-phenylphenol + NADH + H+ + O2
-
Pseudomonas putida (2R,3S)-2,3-dihydro[1,1'-biphenyl]-2,3,5-triol + (2S)-[1,1'-biphenyl]-2,3,3(2H)-triol + NAD+
-
?
1.14.12.11 3-phenylphenol + NADH + H+ + O2
-
Pseudomonas putida UV4 (2R,3S)-2,3-dihydro[1,1'-biphenyl]-2,3,5-triol + (2S)-[1,1'-biphenyl]-2,3,3(2H)-triol + NAD+
-
?
1.14.12.11 4-cresol + NADH + H+ + O2
-
Pseudomonas putida (1R,2R)-6-methylcyclohexa-3,5-diene-1,2,3-triol + (2S)-4-methylcyclohexa-3,5-diene-1,1,2-triol + NAD+
-
?
1.14.12.11 phenol + NADH + H+ + O2
-
Pseudomonas putida (1S,2R)-cyclohexa-3,5-diene-1,2,4-triol + (2S)-cyclohexa-3,5-diene-1,1,2-triol + NAD+
-
?
1.14.12.11 toluene + NADH + H+ + O2
-
Pseudomonas putida (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
?
1.14.12.11 toluene + NADH + H+ + O2
-
Pseudomonas putida UV4 (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.12.11 TDO
-
Pseudomonas putida

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.12.11 NADH
-
Pseudomonas putida