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Literature summary extracted from

  • Kim, H.Y.; Korade, Z.; Tallman, K.A.; Liu, W.; Weaver, C.D.; Mirnics, K.; Porter, N.A.
    Inhibitors of 7-dehydrocholesterol reductase: screening of a collection of pharmacologically active compounds in Neuro2a cells (2016), Chem. Res. Toxicol., 29, 892-900.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.21 1-[3-(2,4,6-trimethoxybenzoyl)propyl]-pyrrolidinium chloride
-
 Mus musculus
1.3.1.21 acebutolol
-
 Mus musculus
1.3.1.21 altanserin
-
 Mus musculus
1.3.1.21 aripiprazole
-
 Mus musculus
1.3.1.21 AY9944 i.e.trans-1,4-bis(2-chloro-benzylaminomethyl) Mus musculus
1.3.1.21 buspirone
-
 Mus musculus
1.3.1.21 captopril
-
 Mus musculus
1.3.1.21 CGS 12066B
-
 Mus musculus
1.3.1.21 cisapride
-
 Mus musculus
1.3.1.21 clobenpropit
-
 Mus musculus
1.3.1.21 dofetilide
-
 Mus musculus
1.3.1.21 donepezil
-
 Mus musculus
1.3.1.21 droperidol
-
 Mus musculus
1.3.1.21 E-4031
-
 Mus musculus
1.3.1.21 esmolol
-
 Mus musculus
1.3.1.21 fluoxetine
-
 Mus musculus
1.3.1.21 formoterol
-
 Mus musculus
1.3.1.21 haloperidol
-
 Mus musculus
1.3.1.21 ifenprodil
-
 Mus musculus
1.3.1.21 isoxsuprine
-
 Mus musculus
1.3.1.21 lobeline
-
 Mus musculus
1.3.1.21 lofexidine
-
 Mus musculus
1.3.1.21 loxoprofen
-
 Mus musculus
1.3.1.21 N-(3-trifluoromethylphenyl)piperazine
-
 Mus musculus
1.3.1.21 nafadotride
-
 Mus musculus
1.3.1.21 naftopidil
-
 Mus musculus
1.3.1.21 nefazodone
-
 Mus musculus
1.3.1.21 oxybutynin
-
 Mus musculus
1.3.1.21 pergolide
-
 Mus musculus
1.3.1.21 perospirone
-
 Mus musculus
1.3.1.21 pirenperone
-
 Mus musculus
1.3.1.21 procaine
-
 Mus musculus
1.3.1.21 risperidone
-
 Mus musculus
1.3.1.21 salmeterol
-
 Mus musculus
1.3.1.21 trazodone
-
 Mus musculus
1.3.1.21 vesamicol
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.21 cholesterol + NADP+ Mus musculus
-
 cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?
1.3.1.21 desmosterol + NADP+ Mus musculus
-
 7-dehydrodesmosterol + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.21 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.21 Neuro2A cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.21 cholesterol + NADP+
-
 Mus musculus cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?
1.3.1.21 desmosterol + NADP+
-
 Mus musculus 7-dehydrodesmosterol + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.21 Dhcr7
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.21 NADP+
-
 Mus musculus