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Literature summary extracted from
- Squalene epoxidase as hypocholesterolemic drug target revisited (2003), Prog. Lipid Res., 42, 37-50.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.17 | (-)-epigallocatechin-3-O-gallate | - |
Rattus norvegicus |  |
| 1.14.14.17 | (-)-epigallocatechin-3-O-gallate | - |
Sus scrofa | |
| 1.14.14.17 | dodecyl gallate | - |
Rattus norvegicus | |
| 1.14.14.17 | dodecyl gallate | - |
Sus scrofa | |
| 1.14.14.17 | FR 194738 | - |
Rattus norvegicus | |
| 1.14.14.17 | FR 194738 | - |
Sus scrofa | |
| 1.14.14.17 | NB-598 | i.e. E-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bisthiophen-5-yl)methoxy]benzene-methanamine hydrochloride, potent competitive inhibitor | Rattus norvegicus | |
| 1.14.14.17 | NB-598 | i.e. E-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bisthiophen-5-yl)methoxy]benzene-methanamine hydrochloride, potent competitive inhibitor | Sus scrofa | |
| 1.14.14.17 | Pharma Project 4501 | - |
Rattus norvegicus | |
| 1.14.14.17 | tellurium | non-competitive inhibitor | Rattus norvegicus | |
| 1.14.14.17 | tellurium | non-competitive inhibitor | Sus scrofa | |
| 1.14.14.17 | tris norsqualene alcohol | - |
Rattus norvegicus | |
| 1.14.14.17 | tris norsqualene alcohol | - |
Sus scrofa | |
| 1.14.14.17 | tris norsqualene cyclopropylamine | - |
Rattus norvegicus | |
| 1.14.14.17 | tris norsqualene cyclopropylamine | - |
Sus scrofa | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.17 | microsome | - |
Rattus norvegicus | - |
- |
| 1.14.14.17 | microsome | - |
Sus scrofa | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.17 | 64000 | - |
x * 64000, SDS-PAGE | Rattus norvegicus |
| 1.14.14.17 | 64000 | - |
x * 64000, SDS-PAGE | Sus scrofa |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.17 | squalene + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.17 | squalene + [reduced NADPH-hemoprotein reductase] + O2 | Sus scrofa | - |
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.17 | Rattus norvegicus | - |
- |
- |
| 1.14.14.17 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.17 | liver | - |
Rattus norvegicus | - |
| 1.14.14.17 | liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.17 | squalene + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.17 | squalene + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sus scrofa | (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.14.17 | ? | x * 64000, SDS-PAGE | Rattus norvegicus |
| 1.14.14.17 | ? | x * 64000, SDS-PAGE | Sus scrofa |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.17 | squalene epoxidase | - |
Rattus norvegicus |
| 1.14.14.17 | squalene epoxidase | - |
Sus scrofa |
| 1.14.14.17 | squalene mono-oxygenase | - |
Rattus norvegicus |
| 1.14.14.17 | squalene mono-oxygenase | - |
Sus scrofa |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.17 | FAD | - |
Rattus norvegicus | |
| 1.14.14.17 | FAD | - |
Sus scrofa | |
| 1.14.14.17 | NADPH | - |
Rattus norvegicus | |
| 1.14.14.17 | NADPH | - |
Sus scrofa | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.17 | 0.002 | - |
tris norsqualene cyclopropylamine | pH and temperature not specified in the publication | Sus scrofa | |
| 1.14.14.17 | 0.004 | - |
tris norsqualene alcohol | pH and temperature not specified in the publication | Sus scrofa | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.17 | 0.0000044 | - |
pH and temperature not specified in the publication | Rattus norvegicus | NB-598 | |
| 1.14.14.17 | 0.0000098 | - |
pH and temperature not specified in the publication | Sus scrofa | FR 194738 | |
| 1.14.14.17 | 0.000061 | - |
pH and temperature not specified in the publication | Sus scrofa | dodecyl gallate | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.14.17 | malfunction | squalene epoxidase inhibition may be responsible for dermatitis and neuropathy | Rattus norvegicus |
| 1.14.14.17 | malfunction | squalene epoxidase inhibition may be responsible for dermatitis and neuropathy | Sus scrofa |
| 1.14.14.17 | metabolism | the enzyme plays a pivotal role in the maintenance of cholesterol homeostasis | Rattus norvegicus |
| 1.14.14.17 | metabolism | the enzyme plays a pivotal role in the maintenance of cholesterol homeostasis | Sus scrofa |
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