EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.3.2.11 | 4-hydroxy-tamoxifen | - |
Homo sapiens | |
3.3.2.11 | 6-ketocholestanol | - |
Homo sapiens | |
3.3.2.11 | 7-ketocholestanol | - |
Homo sapiens | |
3.3.2.11 | 7-ketocholesterol | - |
Homo sapiens | |
3.3.2.11 | alpha-linolenic acid | - |
Homo sapiens | |
3.3.2.11 | amiodarone | - |
Homo sapiens | |
3.3.2.11 | arachidonic acid | - |
Homo sapiens | |
3.3.2.11 | cholestane-3beta,5alpha,6beta-triol | - |
Homo sapiens | |
3.3.2.11 | clomiphene | - |
Homo sapiens | |
3.3.2.11 | docosahexaenoic acid | - |
Homo sapiens | |
3.3.2.11 | haloperidol | - |
Homo sapiens | |
3.3.2.11 | N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine | - |
Homo sapiens | |
3.3.2.11 | oleic acid | - |
Homo sapiens | |
3.3.2.11 | raloxifene | - |
Homo sapiens | |
3.3.2.11 | SR31747A | - |
Homo sapiens | |
3.3.2.11 | tamoxifen | - |
Homo sapiens | |
3.3.2.11 | terbinafine | - |
Homo sapiens | |
3.3.2.11 | tesmilifene | - |
Homo sapiens | |
3.3.2.11 | trifluoroperazine | - |
Homo sapiens | |
3.3.2.11 | U-18666A | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.3.2.11 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.11 | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | Homo sapiens | - |
5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
3.3.2.11 | 5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O | Homo sapiens | better substrate | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.3.2.11 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.3.2.11 | brain | - |
Homo sapiens | - |
3.3.2.11 | intestinal epithelium | - |
Homo sapiens | - |
3.3.2.11 | kidney | - |
Homo sapiens | - |
3.3.2.11 | liver | richest source tissue | Homo sapiens | - |
3.3.2.11 | lung | - |
Homo sapiens | - |
3.3.2.11 | MCF-7 cell | - |
Homo sapiens | - |
3.3.2.11 | skin | - |
Homo sapiens | - |
3.3.2.11 | spleen | - |
Homo sapiens | - |
3.3.2.11 | testis | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.11 | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
3.3.2.11 | 5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O | better substrate | Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.3.2.11 | anti-estrogen binding site | cholesterol epoxide hydrolase is a heterooligomeric complex called the anti-estrogen binding site comprising 3beta-hydroxysterol-DELTA8-DELTA7-isomerase and 3beta-hydroxysterol-DELTA7-reductase | Homo sapiens |
3.3.2.11 | ChEH | - |
Homo sapiens |
3.3.2.11 | cholesterol epoxide hydrolase | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.3.2.11 | 0.000006 | - |
SR31747A | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.000027 | - |
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.000034 | - |
tamoxifen | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.000036 | - |
raloxifene | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.000062 | - |
tesmilifene | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.00009 | - |
U-18666A | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.000135 | - |
trifluoroperazine | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.000145 | - |
4-hydroxy-tamoxifen | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.000733 | - |
amiodarone | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.0042 | - |
7-ketocholesterol | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.0091 | - |
terbinafine | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.0097 | - |
cholestane-3beta,5alpha,6beta-triol | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.012 | - |
docosahexaenoic acid | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.018 | - |
haloperidol | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.024 | - |
arachidonic acid | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.036 | - |
alpha-linolenic acid | pH and temperature not specified in the publication | Homo sapiens | |
3.3.2.11 | 0.054 | - |
oleic acid | pH and temperature not specified in the publication | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.3.2.11 | physiological function | the enzyme plays a potential role in cancer progression and resistance | Homo sapiens |