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Literature summary extracted from

  • Silvente-Poirot, S.; Poirot, M.
    Cholesterol epoxide hydrolase and cancer (2012), Curr. Opin. Pharmacol., 12, 696-703.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.11 4-hydroxy-tamoxifen
-
Homo sapiens
3.3.2.11 6-ketocholestanol
-
Homo sapiens
3.3.2.11 7-ketocholestanol
-
Homo sapiens
3.3.2.11 7-ketocholesterol
-
Homo sapiens
3.3.2.11 alpha-linolenic acid
-
Homo sapiens
3.3.2.11 amiodarone
-
Homo sapiens
3.3.2.11 arachidonic acid
-
Homo sapiens
3.3.2.11 cholestane-3beta,5alpha,6beta-triol
-
Homo sapiens
3.3.2.11 clomiphene
-
Homo sapiens
3.3.2.11 docosahexaenoic acid
-
Homo sapiens
3.3.2.11 haloperidol
-
Homo sapiens
3.3.2.11 N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine
-
Homo sapiens
3.3.2.11 oleic acid
-
Homo sapiens
3.3.2.11 raloxifene
-
Homo sapiens
3.3.2.11 SR31747A
-
Homo sapiens
3.3.2.11 tamoxifen
-
Homo sapiens
3.3.2.11 terbinafine
-
Homo sapiens
3.3.2.11 tesmilifene
-
Homo sapiens
3.3.2.11 trifluoroperazine
-
Homo sapiens
3.3.2.11 U-18666A
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.11 endoplasmic reticulum
-
Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.11 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O Homo sapiens
-
5alpha-cholestane-3beta,5alpha,6beta-triol
-
?
3.3.2.11 5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O Homo sapiens better substrate 5alpha-cholestane-3beta,5alpha,6beta-triol
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.11 brain
-
Homo sapiens
-
3.3.2.11 intestinal epithelium
-
Homo sapiens
-
3.3.2.11 kidney
-
Homo sapiens
-
3.3.2.11 liver richest source tissue Homo sapiens
-
3.3.2.11 lung
-
Homo sapiens
-
3.3.2.11 MCF-7 cell
-
Homo sapiens
-
3.3.2.11 skin
-
Homo sapiens
-
3.3.2.11 spleen
-
Homo sapiens
-
3.3.2.11 testis
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.11 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
-
Homo sapiens 5alpha-cholestane-3beta,5alpha,6beta-triol
-
?
3.3.2.11 5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O better substrate Homo sapiens 5alpha-cholestane-3beta,5alpha,6beta-triol
-
?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.11 anti-estrogen binding site cholesterol epoxide hydrolase is a heterooligomeric complex called the anti-estrogen binding site comprising 3beta-hydroxysterol-DELTA8-DELTA7-isomerase and 3beta-hydroxysterol-DELTA7-reductase Homo sapiens
3.3.2.11 ChEH
-
Homo sapiens
3.3.2.11 cholesterol epoxide hydrolase
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.3.2.11 0.000006
-
SR31747A pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.000027
-
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.000034
-
tamoxifen pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.000036
-
raloxifene pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.000062
-
tesmilifene pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.00009
-
U-18666A pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.000135
-
trifluoroperazine pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.000145
-
4-hydroxy-tamoxifen pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.000733
-
amiodarone pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.0042
-
7-ketocholesterol pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.0091
-
terbinafine pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.0097
-
cholestane-3beta,5alpha,6beta-triol pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.012
-
docosahexaenoic acid pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.018
-
haloperidol pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.024
-
arachidonic acid pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.036
-
alpha-linolenic acid pH and temperature not specified in the publication Homo sapiens
3.3.2.11 0.054
-
oleic acid pH and temperature not specified in the publication Homo sapiens

General Information

EC Number General Information Comment Organism
3.3.2.11 physiological function the enzyme plays a potential role in cancer progression and resistance Homo sapiens