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Literature summary extracted from

  • Uda, N.R.; Creus, M.
    Selectivity of inhibition of N-succinyl-L,L-diaminopimelic acid desuccinylase in bacteria: the product of dapE-gene is not the target of L-captopril antimicrobial activity (2011), Bioinorg. Chem. Appl., 2011, 306465.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.18 expressed in Escherichia coli XL1-Blue cells and in Salmonella enterica strain TN5911 Salmonella enterica

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.18 L-captopril low-micromolar inhibitor, DapE is not the main target of L-captopril inhibition Salmonella enterica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.18 Zn2+ the enzyme possesses a catalytic domain with a di-zinc active site Salmonella enterica

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.18 41600
-
 2 * 41600, estimated from amino acid sequence Salmonella enterica
3.5.1.18 42000
-
 2 * 42000, SD-PAGE Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.18 N-succinyl-LL-2,6-diaminoheptanedioate + H2O Salmonella enterica i.e. N-succinyl-L,L-diaminopimelic acid succinate + LL-2,6-diaminoheptanedioate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.18 Salmonella enterica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.18 N-succinyl-LL-2,6-diaminoheptanedioate + H2O i.e. N-succinyl-L,L-diaminopimelic acid Salmonella enterica succinate + LL-2,6-diaminoheptanedioate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.1.18 homodimer 2 * 41600, estimated from amino acid sequence Salmonella enterica
3.5.1.18 homodimer 2 * 42000, SD-PAGE Salmonella enterica

Synonyms

EC Number Synonyms Comment Organism
3.5.1.18 DapE
-
 Salmonella enterica
3.5.1.18 N-succinyl-L,L-diaminopimelic acid desuccinylase
-
 Salmonella enterica

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.18 0.0018
-
 L-captopril pH and temperature not specified in the publication Salmonella enterica

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.18 0.0033
-
 pH and temperature not specified in the publication Salmonella enterica L-captopril