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Literature summary extracted from
- Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes (2011), Naunyn Schmiedebergs Arch. Pharmacol., 383, 357-372.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | epinephrine | significantly activates cortical adenylyl cyclase | Oryctolagus cuniculus |  |
| 4.6.1.1 | forskolin | significantly activates cortical adenylyl cyclase | Oryctolagus cuniculus | |
| 4.6.1.1 | glucagon | 0.04 mM glucagon significantly activates cortical and medulla adenylyl cyclase | Oryctolagus cuniculus | |
| 4.6.1.1 | isoproterenol | significantly activates cortical adenylyl cyclase | Oryctolagus cuniculus | |
| 4.6.1.1 | additional information | not activated by histamine and 5-HT | Oryctolagus cuniculus | |
| 4.6.1.1 | norepinephrine | significantly activates cortical adenylyl cyclase | Oryctolagus cuniculus | |
| 4.6.1.1 | [8-arginine]vasopressin | 0.01 mM [8-arginine]vasopressin significantly activates cortical and medulla adenylyl cyclase | Oryctolagus cuniculus |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.6.1.1 | expressed in Sf9 insect cells | Oryctolagus cuniculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | 2'(3')-O-(N-methylanthraniloyl)-ATP | - |
Oryctolagus cuniculus | |
| 4.6.1.1 | 2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | - |
Oryctolagus cuniculus | |
| 4.6.1.1 | 2'(3')-O-(N-methylanthraniloyl)-CTP | - |
Oryctolagus cuniculus | |
| 4.6.1.1 | 2'(3')-O-(N-methylanthraniloyl)-GTP | - |
Oryctolagus cuniculus | |
| 4.6.1.1 | 2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | - |
Oryctolagus cuniculus | |
| 4.6.1.1 | 2'(3')-O-(N-methylanthraniloyl)-ITP | highest potency on both cortical and medullary adenylyl cyclase in presence of Mn2+ as well as in presence of Mg2+ | Oryctolagus cuniculus | |
| 4.6.1.1 | 2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | - |
Oryctolagus cuniculus | |
| 4.6.1.1 | 2'(3')-O-(N-methylanthraniloyl)-UTP | - |
Oryctolagus cuniculus | |
| 4.6.1.1 | Ca2+ | cortical adenylyl cyclase AC5 is sensitive to inhibition by Ca2+ | Oryctolagus cuniculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.6.1.1 | 0.013 | - |
ATP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.027 | - |
ATP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.086 | - |
ATP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.13 | - |
ATP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.6.1.1 | membrane | - |
Oryctolagus cuniculus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | Mg2+ | Mg2+ is the physiological cation involved in adenylyl cyclase enzyme activity | Oryctolagus cuniculus | |
| 4.6.1.1 | Mn2+ | may replace Mg2+ | Oryctolagus cuniculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | kidney | - |
Oryctolagus cuniculus | - |
| 4.6.1.1 | renal cortex | isoform AC5 is the major adenylyl cyclase isoform in the cortex of the kidney | Oryctolagus cuniculus | - |
| 4.6.1.1 | renal medulla | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.1 | ATP | - |
Oryctolagus cuniculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | AC5 | isoform | Oryctolagus cuniculus |
| 4.6.1.1 | adenylyl cyclase | - |
Oryctolagus cuniculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | Calmodulin | - |
Oryctolagus cuniculus | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.6.1.1 | 0.000006 | - |
2'(3')-O-(N-methylanthraniloyl)-ITP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000009 | - |
2'(3')-O-(N-methylanthraniloyl)-ITP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.00001 | - |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000013 | - |
2'(3')-O-(N-methylanthraniloyl)-GTP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000014 | - |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000022 | - |
2'(3')-O-(N-methylanthraniloyl)-UTP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000027 | - |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000029 | - |
2'(3')-O-(N-methylanthraniloyl)-ITP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.00003 | - |
2'(3')-O-(N-methylanthraniloyl)-ITP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000031 | - |
2'(3')-O-(N-methylanthraniloyl)-UTP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000032 | - |
2'(3')-O-(N-methylanthraniloyl)-GTP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000042 | - |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000047 | - |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.00005 | - |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000051 | - |
2'(3')-O-(N-methylanthraniloyl)-CTP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.00006 | - |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000061 | - |
2'(3')-O-(N-methylanthraniloyl)-ATP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000072 | - |
2'(3')-O-(N-methylanthraniloyl)-CTP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000075 | - |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000125 | - |
2'(3')-O-(N-methylanthraniloyl)-ATP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000468 | - |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000666 | - |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000706 | - |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.000872 | - |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.001087 | - |
2'(3')-O-(N-methylanthraniloyl)-GTP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.001249 | - |
2'(3')-O-(N-methylanthraniloyl)-GTP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.001435 | - |
2'(3')-O-(N-methylanthraniloyl)-UTP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.0015 | - |
2'(3')-O-(N-methylanthraniloyl)-UTP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.001628 | - |
2'(3')-O-(N-methylanthraniloyl)-ATP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.003115 | - |
2'(3')-O-(N-methylanthraniloyl)-CTP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.003558 | - |
2'(3')-O-(N-methylanthraniloyl)-ATP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
| 4.6.1.1 | 0.004141 | - |
2'(3')-O-(N-methylanthraniloyl)-CTP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
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