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Literature summary extracted from
- Phenoxazinone synthase: whats' in a name? (2009), Trends Biotechnol., 27, 248-258.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.10.3.4 | 2,3-Dimercaptopropanol | - |
Bauhinia monandra |  |
| 1.10.3.4 | 2-Aminophenol | inhibitory above 0.6 mM | Trametes coccinea | |
| 1.10.3.4 | 2-Nitrophenol | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.4 | 3-amino-4-hydroxybenzensulfonic acid | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.4 | 3-hydroxyanthranilic acid | - |
Bauhinia monandra | |
| 1.10.3.4 | 4-hydroxy-3-nitrobenzaldehyde | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.4 | 4-hydroxybenzaldehyde | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.4 | 8-hydroxyquinoline | - |
Streptomyces antibioticus | |
| 1.10.3.4 | Ag+ | - |
Bauhinia monandra | |
| 1.10.3.4 | alpha,alpha'-dipyridyl | - |
Streptomyces antibioticus | |
| 1.10.3.4 | aniline | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.4 | anthranilic acid | - |
Bauhinia monandra | |
| 1.10.3.4 | ascorbic acid | - |
Bauhinia monandra | |
| 1.10.3.4 | ascorbic acid | - |
Trametes coccinea | |
| 1.10.3.4 | Atebrin | - |
Bauhinia monandra | |
| 1.10.3.4 | Atebrin | - |
Tecoma stans | |
| 1.10.3.4 | azide | - |
Bauhinia monandra | |
| 1.10.3.4 | azide | - |
Streptomyces antibioticus | |
| 1.10.3.4 | Co2+ | - |
Tecoma stans | |
| 1.10.3.4 | Cu2+ | - |
Bauhinia monandra | |
| 1.10.3.4 | Cu2+ | - |
Streptomyces antibioticus | |
| 1.10.3.4 | CuSO4 | - |
Trametes coccinea | |
| 1.10.3.4 | cyanide | - |
Bauhinia monandra | |
| 1.10.3.4 | cyanide | - |
Streptomyces antibioticus | |
| 1.10.3.4 | cyanide | - |
Tecoma stans | |
| 1.10.3.4 | cysteine | - |
Bauhinia monandra | |
| 1.10.3.4 | cysteine | - |
Trametes coccinea | |
| 1.10.3.4 | EDTA | - |
Streptomyces antibioticus | |
| 1.10.3.4 | Fe2+ | - |
Bauhinia monandra | |
| 1.10.3.4 | Fe2+ | - |
Streptomyces antibioticus | |
| 1.10.3.4 | Fe3+ | - |
Tecoma stans | |
| 1.10.3.4 | FeSO4 | - |
Trametes coccinea | |
| 1.10.3.4 | glutathione | - |
Bauhinia monandra | |
| 1.10.3.4 | glutathione | - |
Trametes coccinea | |
| 1.10.3.4 | Hg2+ | - |
Bauhinia monandra | |
| 1.10.3.4 | Hg2+ | - |
Tecoma stans | |
| 1.10.3.4 | K+ | - |
Streptomyces antibioticus | |
| 1.10.3.4 | L-tyrosine | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.4 | Mg2+ | - |
Tecoma stans | |
| 1.10.3.4 | N-ethylmaleimide | - |
Bauhinia monandra | |
| 1.10.3.4 | N-ethylmaleimide | - |
Trametes coccinea | |
| 1.10.3.4 | Na3AsO3 | - |
Trametes coccinea | |
| 1.10.3.4 | NaBH4 | - |
Trametes coccinea | |
| 1.10.3.4 | NH4+ | - |
Streptomyces antibioticus | |
| 1.10.3.4 | p-chloromercuribenzoate | - |
Trametes coccinea | |
| 1.10.3.4 | p-hydroxymercuribenzoate | - |
Bauhinia monandra | |
| 1.10.3.4 | phenol | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.4 | Sodium diethyldithiocarbamate | - |
Streptomyces antibioticus | |
| 1.10.3.4 | Zn2+ | - |
Streptomyces antibioticus | |
| 1.10.3.15 | 2-Nitrophenol | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.15 | 3-amino-4-hydroxybenzensulfonic acid | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.15 | 4-hydroxy-3-nitrobenzaldehyde | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.15 | 4-hydroxybenzaldehyde | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.15 | aniline | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.15 | L-tyrosine | - |
Streptomyces griseus subsp. griseus | |
| 1.10.3.15 | phenol | - |
Streptomyces griseus subsp. griseus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.10.3.4 | Cu2+ | GriF is a type 3 copper oxidase and contains two copper atoms | Streptomyces griseus subsp. griseus | |
| 1.10.3.4 | Cu2+ | the enzyme is a blue multicopper oxidase | Streptomyces antibioticus | |
| 1.10.3.4 | Mn2+ | required | Trametes coccinea | |
| 1.10.3.4 | Mn2+ | required | Tecoma stans | |
| 1.10.3.15 | Cu2+ | a type 3 copper oxidase | Streptomyces griseus subsp. griseus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | Streptomyces antibioticus | - |
isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | Trametes coccinea | - |
isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | Tecoma stans | - |
isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | Bauhinia monandra | - |
isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | Streptomyces griseus subsp. griseus | - |
isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2-amino-4-methylphenol + O2 | Streptomyces griseus subsp. griseus | - |
? | - |
? | |
| 1.10.3.4 | 3,4-dihydroxybenzaldehyde + O2 | Streptomyces griseus subsp. griseus | - |
? | - |
? | |
| 1.10.3.4 | 3-amino-4-hydroxybenzaldehyde + O2 | Streptomyces griseus subsp. griseus | - |
? | - |
? | |
| 1.10.3.4 | 3-hydroxyanthranilic acid + O2 | Streptomyces antibioticus | - |
2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid + H2O | - |
? | |
| 1.10.3.4 | 3-hydroxyanthranilic acid + O2 | Streptomyces griseus subsp. griseus | - |
2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid + H2O | - |
? | |
| 1.10.3.4 | 3-hydroxykynurenine + O2 | Streptomyces antibioticus | - |
? | - |
? | |
| 1.10.3.4 | 4-methyl-3-hydroanthranilic acid methyl ester + O2 | Streptomyces antibioticus | - |
? | - |
? | |
| 1.10.3.4 | 4-methyl-3-hydroxyanthranilic acid + O2 | Streptomyces antibioticus | - |
? | - |
? | |
| 1.10.3.4 | catechol + O2 | Streptomyces antibioticus | - |
? | - |
? | |
| 1.10.3.4 | catechol + O2 | Streptomyces griseus subsp. griseus | - |
? | - |
? | |
| 1.10.3.4 | ferrocyanide + O2 | Streptomyces antibioticus | - |
? | - |
? | |
| 1.10.3.4 | L-DOPA + O2 | Streptomyces antibioticus | - |
? | - |
? | |
| 1.10.3.4 | L-DOPA + O2 | Streptomyces griseus subsp. griseus | - |
? | - |
? | |
| 1.10.3.4 | protocatechuic acid + O2 | Streptomyces griseus subsp. griseus | - |
? | - |
? | |
| 1.10.3.4 | thiophenol + O2 | Streptomyces antibioticus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.10.3.4 | Bauhinia monandra | - |
- |
- |
| 1.10.3.4 | Streptomyces antibioticus | - |
- |
- |
| 1.10.3.4 | Streptomyces griseus subsp. griseus | - |
- |
- |
| 1.10.3.4 | Tecoma stans | - |
- |
- |
| 1.10.3.4 | Trametes coccinea | - |
- |
- |
| 1.10.3.15 | Streptomyces griseus subsp. griseus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | - |
Streptomyces antibioticus | isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | - |
Trametes coccinea | isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | - |
Tecoma stans | isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | - |
Bauhinia monandra | isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2 2-aminophenol + 2 O2 | - |
Streptomyces griseus subsp. griseus | isophenoxazine + 2 H2O + H2O2 | - |
? | |
| 1.10.3.4 | 2-amino-4-methylphenol + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.4 | 3,4-dihydroxybenzaldehyde + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.4 | 3-amino-4-hydroxybenzaldehyde + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.4 | 3-hydroxyanthranilic acid + O2 | - |
Streptomyces antibioticus | 2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid + H2O | - |
? | |
| 1.10.3.4 | 3-hydroxyanthranilic acid + O2 | - |
Streptomyces griseus subsp. griseus | 2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid + H2O | - |
? | |
| 1.10.3.4 | 3-hydroxykynurenine + O2 | - |
Streptomyces antibioticus | ? | - |
? | |
| 1.10.3.4 | 4-methyl-3-hydroanthranilic acid methyl ester + O2 | - |
Streptomyces antibioticus | ? | - |
? | |
| 1.10.3.4 | 4-methyl-3-hydroxyanthranilic acid + O2 | - |
Streptomyces antibioticus | ? | - |
? | |
| 1.10.3.4 | catechol + O2 | - |
Streptomyces antibioticus | ? | - |
? | |
| 1.10.3.4 | catechol + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.4 | ferrocyanide + O2 | - |
Streptomyces antibioticus | ? | - |
? | |
| 1.10.3.4 | L-DOPA + O2 | - |
Streptomyces antibioticus | ? | - |
? | |
| 1.10.3.4 | L-DOPA + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.4 | protocatechuic acid + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.4 | thiophenol + O2 | - |
Streptomyces antibioticus | ? | - |
? | |
| 1.10.3.15 | 2-amino-4-methylphenol + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.15 | 3,4-dihydroxybenzaldehyde + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.15 | 3-amino-4-hydroxybenzaldehyde + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.15 | catechol + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.15 | L-DOPA + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.15 | o-aminophenol + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
| 1.10.3.15 | protocatechuic acid + O2 | - |
Streptomyces griseus subsp. griseus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.10.3.4 | 2-aminophenol:oxygen oxidoreductase | - |
Streptomyces antibioticus |
| 1.10.3.4 | 2-aminophenol:oxygen oxidoreductase | - |
Trametes coccinea |
| 1.10.3.4 | 2-aminophenol:oxygen oxidoreductase | - |
Tecoma stans |
| 1.10.3.4 | 2-aminophenol:oxygen oxidoreductase | - |
Bauhinia monandra |
| 1.10.3.4 | 2-aminophenol:oxygen oxidoreductase | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | esophenoxazine synthase | - |
Streptomyces antibioticus |
| 1.10.3.4 | esophenoxazine synthase | - |
Trametes coccinea |
| 1.10.3.4 | esophenoxazine synthase | - |
Tecoma stans |
| 1.10.3.4 | esophenoxazine synthase | - |
Bauhinia monandra |
| 1.10.3.4 | esophenoxazine synthase | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | GriF | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | isophenoxazine synthase | - |
Streptomyces antibioticus |
| 1.10.3.4 | isophenoxazine synthase | - |
Trametes coccinea |
| 1.10.3.4 | isophenoxazine synthase | - |
Tecoma stans |
| 1.10.3.4 | isophenoxazine synthase | - |
Bauhinia monandra |
| 1.10.3.4 | isophenoxazine synthase | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | o-aminophenol oxidase | - |
Streptomyces antibioticus |
| 1.10.3.4 | o-aminophenol oxidase | - |
Trametes coccinea |
| 1.10.3.4 | o-aminophenol oxidase | - |
Tecoma stans |
| 1.10.3.4 | o-aminophenol oxidase | - |
Bauhinia monandra |
| 1.10.3.4 | o-aminophenol oxidase | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | o-aminophenol:O2 oxidoreductase | - |
Streptomyces antibioticus |
| 1.10.3.4 | o-aminophenol:O2 oxidoreductase | - |
Trametes coccinea |
| 1.10.3.4 | o-aminophenol:O2 oxidoreductase | - |
Tecoma stans |
| 1.10.3.4 | o-aminophenol:O2 oxidoreductase | - |
Bauhinia monandra |
| 1.10.3.4 | o-aminophenol:O2 oxidoreductase | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | oxidase, o-aminophenol | - |
Streptomyces antibioticus |
| 1.10.3.4 | oxidase, o-aminophenol | - |
Trametes coccinea |
| 1.10.3.4 | oxidase, o-aminophenol | - |
Tecoma stans |
| 1.10.3.4 | oxidase, o-aminophenol | - |
Bauhinia monandra |
| 1.10.3.4 | oxidase, o-aminophenol | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | phenoxazinone synthase | - |
Streptomyces antibioticus |
| 1.10.3.4 | phenoxazinone synthase | - |
Trametes coccinea |
| 1.10.3.4 | phenoxazinone synthase | - |
Tecoma stans |
| 1.10.3.4 | phenoxazinone synthase | - |
Bauhinia monandra |
| 1.10.3.4 | phenoxazinone synthase | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | PHS | - |
Streptomyces antibioticus |
| 1.10.3.4 | PHS | - |
Trametes coccinea |
| 1.10.3.4 | PHS | - |
Tecoma stans |
| 1.10.3.4 | PHS | - |
Bauhinia monandra |
| 1.10.3.4 | PHS | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.4 | PhsA | - |
Streptomyces antibioticus |
| 1.10.3.15 | GriF | - |
Streptomyces griseus subsp. griseus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.10.3.4 | 40 | - |
- |
Bauhinia monandra |
| 1.10.3.4 | 42 | - |
- |
Streptomyces antibioticus |
| 1.10.3.4 | 45 | - |
- |
Tecoma stans |
| 1.10.3.4 | 55 | - |
- |
Streptomyces griseus subsp. griseus |
| 1.10.3.15 | 55 | - |
- |
Streptomyces griseus subsp. griseus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.10.3.4 | 5 | 5.2 | - |
Streptomyces antibioticus |
| 1.10.3.4 | 6.2 | - |
- |
Tecoma stans |
| 1.10.3.4 | 6.2 | - |
- |
Bauhinia monandra |
| 1.10.3.4 | 8.5 | 10.5 | - |
Streptomyces griseus subsp. griseus |
| 1.10.3.15 | 8.5 | 10.5 | - |
Streptomyces griseus subsp. griseus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.10.3.4 | FAD | - |
Tecoma stans | |
| 1.10.3.4 | additional information | no cofactor required | Bauhinia monandra | |
| 1.10.3.4 | riboflavin 5'-phosphate | - |
Trametes coccinea | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.10.3.4 | Streptomyces antibioticus | gene expression is subject to glucose repression | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.10.3.4 | physiological function | GriF plays a role in the biosynthesis of the antibiotic grixazone | Streptomyces griseus subsp. griseus |
| 1.10.3.4 | physiological function | PhsA plays a role in pigment production | Trametes coccinea |
| 1.10.3.4 | physiological function | PhsA plays a role in spore coat pigmentation and melanin production | Streptomyces antibioticus |
| 1.10.3.4 | physiological function | the enzyme plays a role in atechol production | Bauhinia monandra |
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