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Literature summary extracted from

  • Shi, L.; Yang, Y.; Li, Z.L.; Zhu, Z.W.; Liu, C.H.; Zhu, H.L.
    Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors (2010), Bioorg. Med. Chem., 18, 1659-1664.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 2-bromo-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 2-bromo-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 2-chloro-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 2-chloro-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 2-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 2-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 4-chloro-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 4-chloro-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 5-bromo-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 5-bromo-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 6-chloro-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 6-chloro-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 6-fluoro-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 6-fluoro-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 6-hydroxy-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 6-hydroxy-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 6-methyl-N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 6-methyl-N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 Iproniazid
-
 Rattus norvegicus
1.4.3.4 moclobemide
-
 Rattus norvegicus
1.4.3.4 additional information molecular docking of MAO-A and MAO-B, overview Rattus norvegicus
1.4.3.4 N-(2-morpholinoethyl)nicotinamide
-
 Rattus norvegicus
1.4.3.4 N-(3-morpholinopropyl)nicotinamide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Rattus norvegicus P21396
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 brain
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Rattus norvegicus
1.4.3.4 MAO-B
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.4 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 7.4
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.000045
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.000084
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.0001
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.00018
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 6-chloro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.00032
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 2-bromo-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.00038
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 6-chloro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.00043
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 6-hydroxy-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.00075
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 4-chloro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.0018
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 2-chloro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.0019
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 2-bromo-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.0026
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 2-chloro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.0065
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 2-chloro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.0075
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 4-chloro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.0085
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 2-bromo-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.0094
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 2-chloro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.012
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.015
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 6-fluoro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.023
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 5-bromo-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.026
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 5-bromo-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.026
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 5-chloro-6-hydroxy-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.028
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.034
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 6-chloro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.035
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 2-bromo-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.045
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 2-hydroxy-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.045
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 5,6-dichloro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.048
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 5,6-dichloro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.053
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 4-chloro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.055
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 5-bromo-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.056
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 6-hydroxy-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.065
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 5-bromo-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.068
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.074
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 4-chloro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.075
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 6-chloro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.08
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 6-fluoro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.082
-
 pH 7.4, 37°C, MAO-B Rattus norvegicus 5-chloro-6-hydroxy-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.086
-
 pH 7.4, 37°C, MAO-A Rattus norvegicus 6-methyl-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-A Rattus norvegicus N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-A Rattus norvegicus 2-hydroxy-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-A Rattus norvegicus 6-methyl-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-A Rattus norvegicus 2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 2-hydroxy-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-methyl-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-fluoro-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-hydroxy-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 2-chloro-6-methyl-N-(2-morpholinoethyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 2-hydroxy-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-methyl-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-fluoro-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 6-hydroxy-N-(3-morpholinopropyl)nicotinamide
1.4.3.4 0.1
-
 above, pH 7.4, 37°C, MAO-B Rattus norvegicus 2-chloro-6-methyl-N-(3-morpholinopropyl)nicotinamide