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Literature summary extracted from

  • Fujiyama, N.; Miura, M.; Satoh, S.; Inoue, K.; Kagaya, H.; Saito, M.; Habuchi, T.; Suzuki, T.
    Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients (2009), Xenobiotica, 39, 407-414.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.1 gene CES2, genotyping of CES2 genetic polymorphisms in Japanese population, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.1 additional information genotyping of CES2 genetic polymorphisms, overview. No significant differences in mycophenolic acid pharmacokinetics are observed between CES2 A4595G, C8721T or A-1548G genotype groups. CES2 allelic variants also do not appear to affect plasma mycophenolic acid concentrations between individuals Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.1 bis-4-nitrophenylphosphate
-
 Homo sapiens
3.1.1.1 diisopropylfluorophosphate
-
 Homo sapiens
3.1.1.1 Phenylmethylsulfonylfluoride
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.1 additional information
-
 additional information kinetics of wild-type and mutant enzymes with mycophenolate mofetil, overview Homo sapiens
3.1.1.1 1.03 1.2 mycophenolate mofetil pH 7.4, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.1 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.1 mycophenolate mofetil + H2O Homo sapiens prodrug, activation mycophenolic acid + mofetil
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Homo sapiens
-
 Japanese population, gene CES2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 mycophenolate mofetil + H2O prodrug, activation Homo sapiens mycophenolic acid + mofetil
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 carboxylesterase 2
-
 Homo sapiens
3.1.1.1 CES
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.1 7.4
-
 assay at Homo sapiens