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Literature summary extracted from

  • Abd Alla, J.; Langer, A.; Elzahwy, S.S.; Arman-Kalcek, G.; Streichert, T.; Quitterer, U.
    Angiotensin-converting enzyme (ACE) inhibition down regulates the pro-atherogenic chemokine receptor 9 (CCR9) - chemokine ligand 25 (CCL25) axis (2010), J. Biol. Chem., 285, 23496-23505.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 captopril microarray gene expression profiling of the aorta during atherosclerosis prevention with the ACE inhibitor, overview. Captopril treatment for 7 months strongly decreases the recruitment of proatherogenic immune cells into the aorta. Captopril-mediated inhibition of plaque infiltrating immune cells involves downregulation of the C-C chemokine receptor 9, CCR9, phenotype and physiological mechanism, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Mus musculus
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angiotensin II + His-Leu
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?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Mus musculus
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atherosclerosis-prone apolipoprotein E-deficient C57BL/6J mice
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 aorta
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
Mus musculus angiotensin II + His-Leu
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
Mus musculus
3.4.15.1 angiotensin-converting enzyme
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Mus musculus

General Information

EC Number General Information Comment Organism
3.4.15.1 malfunction atherosclerosis-enhancing effects of angiotensin II Mus musculus