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Literature summary extracted from
- Plant food-derived angiotensin I converting enzyme inhibitory peptides (2009), J. Agric. Food Chem., 57, 5113-5120.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | medicine | ACE is an ideal target, clinically and nutritionally, in the treatment of hypertension | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | Ala-Phe | - |
Homo sapiens |  |
| 3.4.15.1 | Ala-Pro-Gly-Ala-Gly-Val-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Ala-Trp-Pro-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Ala-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Asn-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Asn-Trp-Gly-Pro-Leu-Val | - |
Homo sapiens | |
| 3.4.15.1 | Asn-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Asp-Gly | - |
Homo sapiens | |
| 3.4.15.1 | Asp-Ile-Gly-Tyr-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Asp-Leu-Pro | - |
Homo sapiens | |
| 3.4.15.1 | Asp-Tyr-Val-Gly-Asn | - |
Homo sapiens | |
| 3.4.15.1 | captopril | - |
Homo sapiens | |
| 3.4.15.1 | Gly-Glu-Pro | - |
Homo sapiens | |
| 3.4.15.1 | Gly-Gly-Val-Ile-Pro-Asn | - |
Homo sapiens | |
| 3.4.15.1 | Gly-Pro-Pro | - |
Homo sapiens | |
| 3.4.15.1 | Gly-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | His-His-Leu | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Ala | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Ala-Tyr-Lys-Pro-Ala-Gly | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Asn-Ser-Gln | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Phe-Leu | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Pro-Pro-Gly-Val-Pro-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Thr-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Tyr-Leu-Leu | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Val-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Leu-Ala-Ile-pro-Val-Asn-Lys-Pro | - |
Homo sapiens | |
| 3.4.15.1 | Leu-Arg-Ile-Pro-Val-Ala | - |
Homo sapiens | |
| 3.4.15.1 | Leu-Gly-Ile | - |
Homo sapiens | |
| 3.4.15.1 | Leu-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Leu-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Lys-Asp-Tyr-Arg-Leu | - |
Homo sapiens | |
| 3.4.15.1 | Lys-Leu-Pro-Arg-Gly-Thr-Leu-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Met-Arg-Trp | - |
Homo sapiens | |
| 3.4.15.1 | Met-Arg-Trp-Arg-Asp | - |
Homo sapiens | |
| 3.4.15.1 | additional information | mass spectrometric and structural analysis, and production and purification of plant food-derived ACE inhibitory peptides, bioactivities, overview | Homo sapiens | |
| 3.4.15.1 | Phe-Phe-Leu | - |
Homo sapiens | |
| 3.4.15.1 | Phe-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Phe-Val-Asn-Pro-Gln-Ala-Gly-Ser | - |
Homo sapiens | |
| 3.4.15.1 | Pro-Asn-Asn-Lys-Pro-Phe-Gln | - |
Homo sapiens | |
| 3.4.15.1 | Pro-Ser-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Ser-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Ser-Trp-Ser-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Ser-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Thr-Ala-Pro-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Thr-Gln-Val-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Thr-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Thr-Tyr-Leu-Gly-Ser | - |
Homo sapiens | |
| 3.4.15.1 | Thr-Val-Pro-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Thr-Val-Val-Pro-Gly | - |
Homo sapiens | |
| 3.4.15.1 | Trp-Leu | - |
Homo sapiens | |
| 3.4.15.1 | Trp-Val-Pro-Ser-Val-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Tyr-Gln-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Tyr-Leu | - |
Homo sapiens | |
| 3.4.15.1 | Tyr-Leu-Ala-Gly-Asn-Gln | - |
Homo sapiens | |
| 3.4.15.1 | Tyr-Pro-Lys | - |
Homo sapiens | |
| 3.4.15.1 | Tyr-Tyr-Ala-Pro-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Tyr-Tyr-Ala-Pro-Phe-Asp-Gly-Ile-Leu | - |
Homo sapiens | |
| 3.4.15.1 | Tyr-Val-Val-Phe-Lys | - |
Homo sapiens | |
| 3.4.15.1 | Val-Ile-Glu-Lys-Tyr-Pro | - |
Homo sapiens | |
| 3.4.15.1 | Val-Leu-Ile-Val-Pro | - |
Homo sapiens | |
| 3.4.15.1 | Val-Lys | - |
Homo sapiens | |
| 3.4.15.1 | Val-Met-Asp-Lys-Pro-Gln-Gly | - |
Homo sapiens | |
| 3.4.15.1 | Val-Phe | - |
Homo sapiens | |
| 3.4.15.1 | Val-Phe-Pro-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | Val-Thr-Pro-Ala-Leu-Arg | - |
Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | Cl- | the activity of the C-domain of sACE depends highly on chloride ion concentration and is inactive in its absence, whereas the N-domain can be completely activated at relatively low concentrations of this anion and is still active in the absence of chloride | Homo sapiens | |
| 3.4.15.1 | Zn2+ | ACE is a metallopeptidase. An activated water molecule complexed to Zn2+ acts as the nucleophile to attack the carbonyl group of the targeted peptide bond | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | Homo sapiens | - |
angiotensin II + His-Leu | - |
? | |
| 3.4.15.1 | bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Homo sapiens | - |
somatic and germinal isozymes, sACE and gACE | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
| 3.4.15.1 | bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.15.1 | hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | More | isozyme domain structures with N- and C-domains and the HEXXH motif, overview | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Homo sapiens |
| 3.4.15.1 | angiotensin I converting enzyme | - |
Homo sapiens |
| 3.4.15.1 | gACE | - |
Homo sapiens |
| 3.4.15.1 | germinal ACE | - |
Homo sapiens |
| 3.4.15.1 | More | ACE is a M2 family metallopeptidase | Homo sapiens |
| 3.4.15.1 | sACE | - |
Homo sapiens |
| 3.4.15.1 | somatic ACE | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.00038 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Arg-Ile-Pro-Val-Ala | |
| 3.4.15.1 | 0.00046 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Phe-Pro-Tyr | |
| 3.4.15.1 | 0.00048 | - |
pH and temperature not specified in the publication | Homo sapiens | Asp-Leu-Pro | |
| 3.4.15.1 | 0.00048 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Val-Tyr | |
| 3.4.15.1 | 0.0006 | - |
pH and temperature not specified in the publication | Homo sapiens | Met-Arg-Trp | |
| 3.4.15.1 | 0.00072 | - |
pH and temperature not specified in the publication | Homo sapiens | Asp-Tyr-Val-Gly-Asn | |
| 3.4.15.1 | 0.00074 | - |
pH and temperature not specified in the publication | Homo sapiens | Gly-Gly-Val-Ile-Pro-Asn | |
| 3.4.15.1 | 0.00086 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Tyr-Leu-Gly-Ser | |
| 3.4.15.1 | 0.00169 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Leu-Ile-Val-Pro | |
| 3.4.15.1 | 0.0017 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Pro-Gly-Ala-Gly-Val-Tyr | |
| 3.4.15.1 | 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Val-Pro-Tyr | |
| 3.4.15.1 | 0.0021 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Tyr | |
| 3.4.15.1 | 0.0021 | - |
pH and temperature not specified in the publication | Homo sapiens | Met-Arg-Trp-Arg-Asp | |
| 3.4.15.1 | 0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | His-His-Leu | |
| 3.4.15.1 | 0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Val-Val-Pro-Gly | |
| 3.4.15.1 | 0.0027 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Pro-Gly-Ala-Gly-Val-Tyr | |
| 3.4.15.1 | 0.0034 | - |
pH and temperature not specified in the publication | Homo sapiens | Asp-Ile-Gly-Tyr-Tyr | |
| 3.4.15.1 | 0.00374 | - |
pH and temperature not specified in the publication | Homo sapiens | Phe-Tyr | |
| 3.4.15.1 | 0.004 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Gln-Tyr | |
| 3.4.15.1 | 0.0042 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Ala-Tyr-Lys-Pro-Ala-Gly | |
| 3.4.15.1 | 0.00625 | - |
pH and temperature not specified in the publication | Homo sapiens | Gly-Pro-Pro | |
| 3.4.15.1 | 0.0064 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Tyr | |
| 3.4.15.1 | 0.0069 | - |
pH and temperature not specified in the publication | Homo sapiens | Phe-Val-Asn-Pro-Gln-Ala-Gly-Ser | |
| 3.4.15.1 | 0.0092 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Phe | |
| 3.4.15.1 | 0.0105 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Pro-Lys | |
| 3.4.15.1 | 0.0123 | - |
pH and temperature not specified in the publication | Homo sapiens | Asp-Gly | |
| 3.4.15.1 | 0.013 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Lys | |
| 3.4.15.1 | 0.0134 | - |
pH and temperature not specified in the publication | Homo sapiens | Lys-Leu-Pro-Arg-Gly-Thr-Leu-Phe | |
| 3.4.15.1 | 0.0136 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Ala-Pro-Tyr | |
| 3.4.15.1 | 0.014 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Leu-Ala-Gly-Asn-Gln | |
| 3.4.15.1 | 0.0142 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Tyr | |
| 3.4.15.1 | 0.0151 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Phe | |
| 3.4.15.1 | 0.016 | - |
pH and temperature not specified in the publication | Homo sapiens | Pro-Ser-Tyr | |
| 3.4.15.1 | 0.0164 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Leu | |
| 3.4.15.1 | 0.0175 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Pro-Pro-Gly-Val-Pro-Tyr | |
| 3.4.15.1 | 0.0178 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Phe | |
| 3.4.15.1 | 0.0182 | - |
pH and temperature not specified in the publication | Homo sapiens | Thr-Gln-Val-Tyr | |
| 3.4.15.1 | 0.0183 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Trp-Pro-Phe | |
| 3.4.15.1 | 0.021 | - |
pH and temperature not specified in the publication | Homo sapiens | Asn-Trp-Gly-Pro-Leu-Val | |
| 3.4.15.1 | 0.025 | - |
pH and temperature not specified in the publication | Homo sapiens | Phe-Tyr | |
| 3.4.15.1 | 0.0257 | - |
pH and temperature not specified in the publication | Homo sapiens | Trp-Val-Pro-Ser-Val-Tyr | |
| 3.4.15.1 | 0.0264 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Tyr-Ala-Pro-Phe | |
| 3.4.15.1 | 0.0265 | - |
pH and temperature not specified in the publication | Homo sapiens | Lys-Asp-Tyr-Arg-Leu | |
| 3.4.15.1 | 0.029 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Gly-Ile | |
| 3.4.15.1 | 0.0299 | - |
pH and temperature not specified in the publication | Homo sapiens | Trp-Leu | |
| 3.4.15.1 | 0.0326 | - |
pH and temperature not specified in the publication | Homo sapiens | Asn-Tyr | |
| 3.4.15.1 | 0.033 | - |
pH and temperature not specified in the publication | Homo sapiens | Pro-Asn-Asn-Lys-Pro-Phe-Gln | |
| 3.4.15.1 | 0.037 | - |
pH and temperature not specified in the publication | Homo sapiens | Phe-Phe-Leu | |
| 3.4.15.1 | 0.039 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Met-Asp-Lys-Pro-Gln-Gly | |
| 3.4.15.1 | 0.039 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Thr-Phe | |
| 3.4.15.1 | 0.04 | - |
pH and temperature not specified in the publication | Homo sapiens | Gly-Glu-Pro | |
| 3.4.15.1 | 0.041 | - |
pH and temperature not specified in the publication | Homo sapiens | captopril | |
| 3.4.15.1 | 0.042 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Tyr-Leu-Leu | |
| 3.4.15.1 | 0.044 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Val-Val-Phe-Lys | |
| 3.4.15.1 | 0.0448 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Phe-Leu | |
| 3.4.15.1 | 0.046 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Asn-Ser-Gln | |
| 3.4.15.1 | 0.0463 | - |
pH and temperature not specified in the publication | Homo sapiens | Asn-Phe | |
| 3.4.15.1 | 0.064 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr | |
| 3.4.15.1 | 0.065 | - |
pH and temperature not specified in the publication | Homo sapiens | Trp-Leu | |
| 3.4.15.1 | 0.0663 | - |
pH and temperature not specified in the publication | Homo sapiens | Ser-Tyr | |
| 3.4.15.1 | 0.07 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Ala-Ile-pro-Val-Asn-Lys-Pro | |
| 3.4.15.1 | 0.0721 | - |
pH and temperature not specified in the publication | Homo sapiens | Gly-Tyr | |
| 3.4.15.1 | 0.0763 | - |
pH and temperature not specified in the publication | Homo sapiens | Ser-Trp-Ser-Phe | |
| 3.4.15.1 | 0.0824 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Thr-Pro-Ala-Leu-Arg | |
| 3.4.15.1 | 0.083 | - |
pH and temperature not specified in the publication | Homo sapiens | Tyr-Tyr-Ala-Pro-Phe-Asp-Gly-Ile-Leu | |
| 3.4.15.1 | 0.097 | - |
pH and temperature not specified in the publication | Homo sapiens | Val-Ile-Glu-Lys-Tyr-Pro | |
| 3.4.15.1 | 0.1 | - |
pH and temperature not specified in the publication | Homo sapiens | Ala-Tyr | |
| 3.4.15.1 | 0.126 | - |
pH and temperature not specified in the publication | Homo sapiens | Leu-Phe | |
| 3.4.15.1 | 0.1302 | - |
pH and temperature not specified in the publication | Homo sapiens | Ser-Phe | |
| 3.4.15.1 | 0.153 | - |
pH and temperature not specified in the publication | Homo sapiens | Ile-Ala | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | physiological function | angiotensin I-converting enzyme, ACE, catalyzes the formation of vasoconstrictor, angiotensin II, and the inactivation of vasodilator, bradykinin | Homo sapiens |
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