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Literature summary extracted from
- Colorimetric, high-throughput assay for screening angiotensin I-converting enzyme inhibitors (2009), Anal. Chem., 81, 9388-9394.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | captopril | - |
Sus scrofa |  |
| 3.4.15.1 | enalapril | - |
Sus scrofa | |
| 3.4.15.1 | lisinopril | - |
Sus scrofa | |
| 3.4.15.1 | additional information | preparation ACE inhibitor peptides from the enzymatic hydrolysis of arachin, the major storage protein of Arachis hypogaea, overview | Sus scrofa | |
| 3.4.15.1 | ramipril | - |
Sus scrofa | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.0308 | - |
hippuryl-His-Leu | - |
Sus scrofa | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.15.1 | membrane | bound | Sus scrofa | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | Sus scrofa | - |
angiotensin II + His-Leu | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Sus scrofa | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | glycoprotein | - |
Sus scrofa |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.15.1 | lung and kidney enzyme partially by acetone extraction | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | epithelial cell | of pulmonary capillaries | Sus scrofa | - |
| 3.4.15.1 | kidney | - |
Sus scrofa | - |
| 3.4.15.1 | lung | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | - |
Sus scrofa | angiotensin II + His-Leu | - |
? | |
| 3.4.15.1 | hippuryl-His-Leu + H2O | colorimetric quantification of released hippuric acid, using pyridine and benzene sulfonyl chloride, assay method evaluation, overview | Sus scrofa | hippuric acid + His-Leu | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Sus scrofa |
| 3.4.15.1 | angiotensin I-converting enzyme | - |
Sus scrofa |
| 3.4.15.1 | peptidyl dipeptide hydrolase | - |
Sus scrofa |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 37 | - |
assay at | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 8.2 | - |
assay at | Sus scrofa |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | physiological function | angiotensin I-converting enzyme plays a pivotal role in blood pressure regulation | Sus scrofa |
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