EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | interleukin-6 | directly activates AMPK in vivo and in vitro. Activates AMPK in skeletal muscle by increasing the concentration of cAMP and the AMP:ATP ratio. AMPK activation coincides temporally with a nearly 3fold increase in the AMP:ATP ratio in the extensor digitorum longus | Rattus norvegicus | |
2.7.11.31 | isoproterenol | - |
Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | 2'5'-dideoxyadenosine | inhibits ability of interleukin-6 to activate AMPK | Rattus norvegicus | |
2.7.11.31 | propranolol | effects of interleukin-6 on both AMPK activity and energy state are inhibited by coincubation with propranolol, suggesting involvement of beta-adrenergic signaling | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.31 | Rattus norvegicus | - |
male sprague-dawley rats | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.31 | extensor digitorum longus | - |
Rattus norvegicus | - |
2.7.11.31 | gastrocnemius | - |
Rattus norvegicus | - |
2.7.11.31 | myotube | - |
Rattus norvegicus | - |
2.7.11.31 | skeletal muscle | - |
Rattus norvegicus | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.31 | AMP-activated protein kinase | - |
Rattus norvegicus |
2.7.11.31 | AMPK | - |
Rattus norvegicus |