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Literature summary extracted from

  • Fechter, M.H.; Gruber, K.; Avi, M.; Skranc, W.; Schuster, C.; Pöchlauer, P.; Klepp, K.O.; Griengl, H.
    Stereoselective biocatalytic synthesis of (S)-2-hydroxy-2-methylbutyric acid via substrate engineering by using "thio-disguised" precursors and oxynitrilase catalysis (2007), Chemistry, 13, 3369-3376.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.10 cyanide + benzaldehyde Prunus dulcis
-
 (R)-mandelonitrile
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.10 Prunus dulcis
-
-
-
4.1.2.47 Hevea brasiliensis P52704
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.10 cyanide + 3-tetrahydrothiophenone the enzyme, that shows (R)-stereospecificity for its natural substrate shows S-stereselectivity with the heterocyclic ketone as substrate Prunus dulcis (S)-3-hydroxytetrahydrothiophene-3-carbonitrile
-
 ?
4.1.2.10 cyanide + benzaldehyde
-
 Prunus dulcis (R)-mandelonitrile
-
 ?
4.1.2.47 cyanide + 3-tetrahydrothiophenone
-
 Hevea brasiliensis (S)-3-hydroxytetrahydrothiophene-3-carbonitrile
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.10 (R)-selective HNL
-
 Prunus dulcis
4.1.2.10 PaHNL
-
 Prunus dulcis
4.1.2.47 (S)-selective HNL
-
 Hevea brasiliensis
4.1.2.47 HbHNL
-
 Hevea brasiliensis