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Literature summary extracted from

  • Su, H.; Gunter, J.H.; de Vries, M.; Connor, T.; Wanyonyi, S.; Newell, F.S.; Segal, D.; Molero, J.C.; Reizes, O.; Prins, J.B.; Hutley, L.J.; Walder, K.; Whitehead, J.P.
    Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity (2009), Biochem. Biophys. Res. Commun., 386, 351-355.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.205 medicine inhibition of IMPDH may represent a novel strategy to reduce adipose tissue mass Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 mycophenolate mofetil prodrug of mycophenolic acid, treatment of diet-induced obese mice with mycophenolate mofetil for 28 days does not affect food intake or lean body mass but reduces body fat content (by 36%), adipocyte size and number and the appearance of hepatic steatosis Mus musculus
1.1.1.205 Mycophenolic acid in 3T3-L1 preadipocytes inhibition of IMPDH with mycophenolic acid reduces intracellular GTP levels by 60% (p <0.05) and blocks adipogenesis. Co-treatment with guanosine restores GTP levels and adipogenesis Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.205 3T3-L1 cell
-
 Mus musculus
-
1.1.1.205 adipocyte
-
 Mus musculus
-
1.1.1.205 preadipocyte
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.205 IMPDH
-
 Mus musculus
1.1.1.205 inosine monophosphate dehydrogenase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.1.1.205 Mus musculus IMPDH protein expression is transiently increased during differentiation of 3T3-L1 preadipocytes. Total IMPDH protein levels and activity are highest around day 3 up

General Information

EC Number General Information Comment Organism
1.1.1.205 physiological function IMPDH activity is required for differentiation of preadipocytes into mature, lipid-laden adipocytes and maintenance of adipose tissue mass Mus musculus