EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.15.1 | 2-hydroxyemodin 1-methylether | 47.52% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
3.4.15.1 | alaternin | 24.26% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
3.4.15.1 | captopril | 87.87% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
3.4.15.1 | emodin | 45.79% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
3.4.15.1 | gluco-aurantioobtusin | competitive inhibitor, 137.62% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
3.4.15.1 | additional information | ACE is not inhibited by gluco-obtusifolin, obtusifolin, aurantioobtusin, cassitoroside, toralactone gentiobioside, chrysophanol triglucoside, questin, and cassiaside; both of the methanol extracts from the raw and roasted Cassia tora seeds exhibit significant inhibitory properties against ACE, demonstrating more than 50% inhibition at a concentration of 0.16393 mg/ml | Oryctolagus cuniculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.1 | angiotensin I + H2O | Oryctolagus cuniculus | - |
angiotensin II + L-His-L-Leu | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.15.1 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.15.1 | lung | - |
Oryctolagus cuniculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.15.1 | angiotensin I + H2O | - |
Oryctolagus cuniculus | angiotensin II + L-His-L-Leu | - |
? | |
3.4.15.1 | N-[3-(2-furyl)acryloyl]-L-Phe-Gly-Gly + H2O | - |
Oryctolagus cuniculus | 2-furylacrylic acid + L-Phe-Gly-Gly | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.15.1 | ACE | - |
Oryctolagus cuniculus |
3.4.15.1 | angiotensin-converting enzyme | - |
Oryctolagus cuniculus |
3.4.15.1 | peptidyldipeptide hydrolase | - |
Oryctolagus cuniculus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.15.1 | 0.000083 | - |
gluco-aurantioobtusin | in 50 mM Tris-HCl buffer (pH 7.5) | Oryctolagus cuniculus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.15.1 | 0.03024 | - |
in 50 mM Tris-HCl buffer (pH 7.5) | Oryctolagus cuniculus | gluco-aurantioobtusin |