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Literature summary extracted from

  • Hyun, S.K.; Lee, H.; Kang, S.S.; Chung, H.Y.; Choi, J.S.
    Inhibitory activities of Cassia tora and its anthraquinone constituents on angiotensin-converting enzyme (2009), Phytother. Res., 23, 178-184.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 2-hydroxyemodin 1-methylether 47.52% inhibition at 1.63 ng/ml Oryctolagus cuniculus
3.4.15.1 alaternin 24.26% inhibition at 1.63 ng/ml Oryctolagus cuniculus
3.4.15.1 captopril 87.87% inhibition at 1.63 ng/ml Oryctolagus cuniculus
3.4.15.1 emodin 45.79% inhibition at 1.63 ng/ml Oryctolagus cuniculus
3.4.15.1 gluco-aurantioobtusin competitive inhibitor, 137.62% inhibition at 1.63 ng/ml Oryctolagus cuniculus
3.4.15.1 additional information ACE is not inhibited by gluco-obtusifolin, obtusifolin, aurantioobtusin, cassitoroside, toralactone gentiobioside, chrysophanol triglucoside, questin, and cassiaside; both of the methanol extracts from the raw and roasted Cassia tora seeds exhibit significant inhibitory properties against ACE, demonstrating more than 50% inhibition at a concentration of 0.16393 mg/ml Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Oryctolagus cuniculus
-
angiotensin II + L-His-L-Leu
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 lung
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
Oryctolagus cuniculus angiotensin II + L-His-L-Leu
-
?
3.4.15.1 N-[3-(2-furyl)acryloyl]-L-Phe-Gly-Gly + H2O
-
Oryctolagus cuniculus 2-furylacrylic acid + L-Phe-Gly-Gly
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
Oryctolagus cuniculus
3.4.15.1 angiotensin-converting enzyme
-
Oryctolagus cuniculus
3.4.15.1 peptidyldipeptide hydrolase
-
Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.15.1 0.000083
-
gluco-aurantioobtusin in 50 mM Tris-HCl buffer (pH 7.5) Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.03024
-
in 50 mM Tris-HCl buffer (pH 7.5) Oryctolagus cuniculus gluco-aurantioobtusin