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Literature summary extracted from

  • Giebultowicz, J.; Wolinowska, R.; Sztybor, A.; Pietrzak, M.; Wroczy?ski, P.; Wierzchowski, J.
    Salivary aldehyde dehydrogenase: activity towards aromatic aldehydes and comparison with recombinant ALDH3A1 (2009), Molecules, 14, 2363-2372.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.3 into the vector pET28a for expression in Escherichia coli BL21DE3 cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.00016
-
 6-methoxy-2-naphthaldehyde recombinant ALDH3A1 Homo sapiens
1.2.1.3 0.0002
-
 6-methoxy-2-naphthaldehyde salivary ALDH Homo sapiens
1.2.1.3 0.0004
-
 2-naphthaldehyde recombinant ALDH3A1 Homo sapiens
1.2.1.3 0.00046
-
 2-naphthaldehyde salivary ALDH Homo sapiens
1.2.1.3 0.0042
-
 4-Dimethylaminobenzaldehyde recombinant ALDH3A1 Homo sapiens
1.2.1.3 0.006
-
 cinnamic aldehyde recombinant ALDH3A1 Homo sapiens
1.2.1.3 0.0072
-
 6-dimethylamino-2-naphthaldehyde salivary ALDH Homo sapiens
1.2.1.3 0.019
-
 4-methoxybenzaldehyde recombinant ALDH3A1 Homo sapiens
1.2.1.3 0.02
-
 6-dimethylamino-2-naphthaldehyde recombinant ALDH3A1 Homo sapiens
1.2.1.3 0.148
-
 benzaldehyde recombinant ALDH3A1 Homo sapiens
1.2.1.3 0.155
-
 4-hydroxy-3-methoxybenzaldehyde recombinant ALDH3A1 Homo sapiens
1.2.1.3 0.16
-
 benzaldehyde salivary ALDH Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.3 52000
-
 determined by SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3 recombinant ALDH3A1 is isolated with Ni-NTA Fast Start Kit Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 cornea
-
 Homo sapiens
-
1.2.1.3 lung
-
 Homo sapiens
-
1.2.1.3 saliva
-
 Homo sapiens
-
1.2.1.3 stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 1-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 1-naphthoic acid + NADH + H+
-
 ?
1.2.1.3 2-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 2-naphthoic acid + NADH + H+
-
 ?
1.2.1.3 4-dimethylamino-1-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 4-dimethylamino-1-naphthoic acid + NADH + H+
-
 ?
1.2.1.3 4-dimethylaminobenzaldehyde + NAD+ + H2O
-
 Homo sapiens 4-dimethylaminobenzoate + NADH + H+
-
 ?
1.2.1.3 4-hydroxy-3-methoxybenzaldehyde + NAD+ + H2O
-
 Homo sapiens 4-hydroxy-3-methoxybenzoate + NADH + H+
-
 ?
1.2.1.3 4-methoxy-1-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 4-methoxy-1-naphthoic acid + NADH + H+
-
 ?
1.2.1.3 4-methoxybenzaldehyde + NAD+ + H2O
-
 Homo sapiens 4-methoxybenzoate + NADH + H+
-
 ?
1.2.1.3 6-dimethylamino-2-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 6-dimethylamino-2-naphthoic acid + NADH + H+
-
 ?
1.2.1.3 6-methoxy-2-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 6-methoxy-2-naphthoic acid + NADH + H+
-
 ?
1.2.1.3 7-methoxy-1-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 7-methoxy-1-naphthoic acid + NADH + H+
-
 ?
1.2.1.3 benzaldehyde + NAD+ + H2O
-
 Homo sapiens benzoate + NADH + H+
-
 ?
1.2.1.3 cinnamic aldehyde + NAD+ + H2O
-
 Homo sapiens cinnamic acid + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.3 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 aldehyde dehydrogenase
-
 Homo sapiens
1.2.1.3 ALDH3A1
-
 Homo sapiens
1.2.1.3 sALDH
-
 Homo sapiens
1.2.1.3 salvery aldehyde dehydrogenase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.3 25
-
 activity assay Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.3 7.5
-
 activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens