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Literature summary extracted from

  • Goeminne, A.; Berg, M.; McNaughton, M.; Bal, G.; Surpateanu, G.; Van der Veken, P.; De Prol, S.; Versees, W.; Steyaert, J.; Haemers, A.; Augustyns, K.
    N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase (2008), Bioorg. Med. Chem., 16, 6752-6763.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.1 expressed in Escherichia coli WK6 cells Trypanosoma vivax

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.1 (2R,3R,4S)-1-benzyl-2-(hydroxymethyl)pyrrolidine-3,4-diol
-
 Trypanosoma vivax
3.2.2.1 (2R,3R,4S)-2-(hydroxymethyl)-1-(4-iodobenzyl)pyrrolidine-3,4-diol
-
 Trypanosoma vivax
3.2.2.1 (2R,3R,4S)-2-(hydroxymethyl)-1-(4-nitrobenzyl)pyrrolidine-3,4-diol
-
 Trypanosoma vivax
3.2.2.1 (2R,3R,4S,5S)-2-(hydroxymethyl)-5-phenylpyrrolidine-3,4-diol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(1-isoquinolinyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(1-methyl-1H-1,2,3-benzotriazol-5-yl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(1-methyl-1H-benzimidazol-2-yl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(2-aminopyridin-3-yl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(2-naphthyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(2-quinolinyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(3-cyanobenzyl)-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(3-indolyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(3-nitrobenzyl)-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(3-quinolinyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(4-cyanobenzyl)-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(4-methyl-2-phenylpyrimidin-5-yl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(4-pyridinyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(4-quinolinyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(6-methoxypyridin-3-yl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(7-methoxy-indol-3-yl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(7-quinolinyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(8-hydroxyquinolin-2-yl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(8-quinolinyl)methyl-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-[3-(1H-pyrrol-1-yl)benzyl]-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-[4-(1H-pyrazol-1-yl)benzyl]-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-[4-(1H-pyrrol-1-yl)benzyl]-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1-[2-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]ethyl]guanidine
-
 Trypanosoma vivax
3.2.2.1 1-[3-[(2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]propyl]guanidine
-
 Trypanosoma vivax
3.2.2.1 3-deazaadenosine
-
 Trypanosoma vivax
3.2.2.1 immucillin-A
-
 Trypanosoma vivax
3.2.2.1 immucillin-H
-
 Trypanosoma vivax
3.2.2.1 N-(9-deazaadenin-9-yl)methyl-1,4-dideoxy-1,4-imino-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 N-(9-deazahypoxanthin-9-yl)methyl-1,4-dideoxy-1,4-imino-D-ribitol
-
 Trypanosoma vivax

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.1 Trypanosoma vivax Q9GPQ4
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.2.1 Ni-NTA column chromatography and Superdex-200 gel filtration Trypanosoma vivax

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.1 4-nitrophenyl beta-D-ribofuranoside + H2O
-
 Trypanosoma vivax 4-nitrophenol + D-ribose
-
 ?
3.2.2.1 adenosine + H2O preferred substrate Trypanosoma vivax adenine + D-ribose
-
 ?
3.2.2.1 guanosine + H2O preferred substrate Trypanosoma vivax guanine + D-ribose
-
 ?
3.2.2.1 inosine + H2O preferred substrate Trypanosoma vivax hypoxanthine + D-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.1 IAG-NH
-
 Trypanosoma vivax
3.2.2.1 purine specific nucleoside hydrolase
-
 Trypanosoma vivax

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.2.1 0.0000041
-
 N-(9-deaza-adenin-9-yl)methyl-1,4-dideoxy-1,4-imino-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0000044
-
 N-(9-deazahypoxanthin-9-yl)methyl-1,4-dideoxy-1,4-imino-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0000108
-
 1,4-dideoxy-1,4-imino-N-(8-quinolinyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.000063
-
 1,4-dideoxy-1,4-imino-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.00018
-
 1,4-dideoxy-1,4-imino-N-(2-quinolinyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.00072
-
 1,4-dideoxy-1,4-imino-N-(1-methyl-1H-1,2,3-benzotriazol-5-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.00072
-
 1,4-dideoxy-1,4-imino-N-(7-quinolinyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.00075
-
 1,4-dideoxy-1,4-imino-N-(1-isoquinolinyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.001
-
 1,4-dideoxy-1,4-imino-N-[4-(1H-pyrrol-1-yl)benzyl]-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.001
-
 1,4-dideoxy-1,4-imino-N-(8-hydroxyquinolin-2-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0012
-
 1,4-dideoxy-1,4-imino-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0012
-
 1,4-dideoxy-1,4-imino-N-[4-(1H-pyrazol-1-yl)benzyl]-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.002
-
 1,4-dideoxy-1,4-imino-N-(2-naphthyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0021
-
 1,4-dideoxy-1,4-imino-N-(1-methyl-1H-benzimidazol-2-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0023
-
 1,4-dideoxy-1,4-imino-N-(3-nitrobenzyl)-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0023
-
 1,4-dideoxy-1,4-imino-N-(7-methoxy-indol-3-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0034
-
 1,4-dideoxy-1,4-imino-N-[3-(1H-pyrrol-1-yl)benzyl]-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0038
-
 1,4-dideoxy-1,4-imino-N-(3-cyanobenzyl)-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.0043
-
 (2R,3R,4S)-2-(hydroxymethyl)-1-(4-iodobenzyl)pyrrolidine-3,4-diol
-
 Trypanosoma vivax
3.2.2.1 0.0075
-
 (2R,3R,4S)-2-(hydroxymethyl)-1-(4-nitrobenzyl)pyrrolidine-3,4-diol
-
 Trypanosoma vivax
3.2.2.1 0.012
-
 1,4-dideoxy-1,4-imino-N-(3-indolyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.018
-
 1-[2-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]ethyl]guanidine
-
 Trypanosoma vivax
3.2.2.1 0.02
-
 1,4-dideoxy-1,4-imino-N-(4-pyridinyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.02
-
 1,4-dideoxy-1,4-imino-N-(3-quinolinyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.026
-
 1,4-dideoxy-1,4-imino-N-(4-cyanobenzyl)-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.029
-
 1,4-dideoxy-1,4-imino-N-(4-quinolinyl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.032
-
 1,4-dideoxy-1,4-imino-N-(6-methoxypyridin-3-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.04
-
 1-[3-[(2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]propyl]guanidine
-
 Trypanosoma vivax
3.2.2.1 0.043
-
 1,4-dideoxy-1,4-imino-N-(4-methyl-2-phenylpyrimidin-5-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.059
-
 (2R,3R,4S)-1-benzyl-2-(hydroxymethyl)pyrrolidine-3,4-diol
-
 Trypanosoma vivax
3.2.2.1 0.12
-
 1,4-dideoxy-1,4-imino-N-(2-aminopyridin-3-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
3.2.2.1 0.253
-
 (2R,3R,4S,5S)-2-(hydroxymethyl)-5-phenylpyrrolidine-3,4-diol
-
 Trypanosoma vivax