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Literature summary extracted from

  • Enomoto, H.; Morikawa, Y.; Miyake, Y.; Tsuji, F.; Mizuchi, M.; Suhara, H.; Fujimura, K.; Horiuchi, M.; Ban, M.
    Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 4529-4532.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 (2S)-1-[(2R)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid 5% inhibition at 1 mM Homo sapiens
3.3.2.6 (2S)-1-[(2R)-2-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (2S,4R)-3-(2-methyl-3-sulfanylpropanoyl)-2-naphthalen-1-yl-1,3-thiazolidine-4-carboxylic acid 58% inhibition at 1 mM Homo sapiens
3.3.2.6 (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-[(2-phenylethyl)sulfanyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-[(3-phenylpropyl)sulfanyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-[(naphthalen-1-ylmethyl)sulfanyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-[(naphthalen-2-ylmethyl)sulfanyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (2S,4S)-4-(benzylsulfanyl)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (2S,4S)-4-[(2-methylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (2S,4S)-4-[(3-methylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (2S,4S)-4-[[4-(methylsulfanyl)benzyl]sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
-
 Homo sapiens
3.3.2.6 (4R)-2-furan-2-yl-3-[(2S)-2-methyl-3-sulfanylpropanoyl]-1,3-thiazolidine-4-carboxylic acid 36% inhibition at 1 mM Homo sapiens
3.3.2.6 (4R)-3-[(2R)-2-methyl-3-sulfanylpropanoyl]-1,3-thiazolidine-4-carboxylic acid 18% inhibition at 1 mM Homo sapiens
3.3.2.6 (4R)-3-[(2S)-2-methyl-3-sulfanylpropanoyl]-1,3-thiazolidine-4-carboxylic acid 58% inhibition at 1 mM Homo sapiens
3.3.2.6 (4R)-3-[(2S)-2-methyl-3-sulfanylpropanoyl]-2-pyridin-4-yl-1,3-thiazolidine-4-carboxylic acid 25% inhibition at 1 mM Homo sapiens
3.3.2.6 (4R)-3-[(2S)-2-methyl-3-sulfanylpropanoyl]-2-thiophen-2-yl-1,3-thiazolidine-4-carboxylic acid 14% inhibition at 1 mM Homo sapiens
3.3.2.6 (4R)-4-[[4-(1-methylethyl)benzyl]sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
-
 Homo sapiens
3.3.2.6 (4R)-N-mercaptoacylthiazolidine-4-carboxylic acid
-
 Homo sapiens
3.3.2.6 (4S)-4-([2-[4-(1-methylethyl)phenyl]ethyl]sulfanyl)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
-
 Homo sapiens
3.3.2.6 (4S)-4-([3-[4-(1-methylethyl)phenyl]propyl]sulfanyl)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
-
 Homo sapiens
3.3.2.6 (4S)-4-[(4-cyclohexylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
-
 Homo sapiens
3.3.2.6 (4S)-4-[(4-tert-butylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
-
 Homo sapiens
3.3.2.6 (4S)-4-[[4-(1-methylethyl)benzyl]sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
-
 Homo sapiens
3.3.2.6 captopril 59% inhibition at 1 mM Homo sapiens
3.3.2.6 N-mercaptoacyl-L-proline
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.6 cytosol
-
 Homo sapiens 5829
-
3.3.2.6 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase
-
 Homo sapiens
3.3.2.6 LTA4 hydrolase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.6 0.000031
-
-
 Homo sapiens (4S)-4-[(4-tert-butylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
3.3.2.6 0.000034
-
-
 Homo sapiens (4S)-4-[(4-cyclohexylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
3.3.2.6 0.000052
-
-
 Homo sapiens (4S)-4-[[4-(1-methylethyl)benzyl]sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
3.3.2.6 0.00012
-
-
 Homo sapiens (2S,4S)-4-[[4-(methylsulfanyl)benzyl]sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
3.3.2.6 0.00029
-
-
 Homo sapiens (4R)-4-[[4-(1-methylethyl)benzyl]sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
3.3.2.6 0.00079
-
-
 Homo sapiens (4S)-4-([2-[4-(1-methylethyl)phenyl]ethyl]sulfanyl)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
3.3.2.6 0.00084
-
-
 Homo sapiens (2S,4S)-4-[(2-methylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
3.3.2.6 0.0011
-
-
 Homo sapiens (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-[(3-phenylpropyl)sulfanyl]pyrrolidine-2-carboxylic acid
3.3.2.6 0.0011
-
-
 Homo sapiens (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-[(naphthalen-2-ylmethyl)sulfanyl]pyrrolidine-2-carboxylic acid
3.3.2.6 0.0027
-
-
 Homo sapiens (4S)-4-([3-[4-(1-methylethyl)phenyl]propyl]sulfanyl)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
3.3.2.6 0.0036
-
-
 Homo sapiens (2S,4S)-4-(benzylsulfanyl)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
3.3.2.6 0.0051
-
-
 Homo sapiens (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-[(2-phenylethyl)sulfanyl]pyrrolidine-2-carboxylic acid
3.3.2.6 0.0092
-
-
 Homo sapiens (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-[(naphthalen-1-ylmethyl)sulfanyl]pyrrolidine-2-carboxylic acid
3.3.2.6 0.01
-
 IC50 above 0.01 mM Homo sapiens (2S,4S)-4-[(3-methylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid