Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Otomo, M.; Takahashi, K.; Miyoshi, H.; Osada, K.; Nakashima, H.; Yamaguchi, N.
    Some selective serotonin reuptake inhibitors inhibit dynamin I guanosine triphosphatase (GTPase) (2008), Biol. Pharm. Bull., 31, 1489-1495.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.5.5 L-phosphatidylserine binds the pleckstrin homology domain of dynamin and enhances its GTPase activity Mus musculus
3.6.5.5 phosphatidylinositol-4,5-bisphosphate binds the pleckstrin homology domain of dynamin and enhances its GTPase activity Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.5.5 His-tagged dynamin I is expressed in Escherichia coli Rosetta2 (DE3) cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.5 (1R,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide milnacipran Mus musculus
3.6.5.5 (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidine paroxetine Mus musculus
3.6.5.5 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine mianserin Mus musculus
3.6.5.5 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro[2]benzofuran-5-carbonitrile citalopram Mus musculus
3.6.5.5 10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine desipramine Mus musculus
3.6.5.5 2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethylamine zotepine Mus musculus
3.6.5.5 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine nortriptyline Mus musculus
3.6.5.5 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine chlorpromazine Mus musculus
3.6.5.5 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine imipramine Mus musculus
3.6.5.5 3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine clomipramine Mus musculus
3.6.5.5 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one haloperidol Mus musculus
3.6.5.5 5H-dibenz[b,f]azepine-5-carboxamide carbamazepine Mus musculus
3.6.5.5 fluvoxamine a noncompetitive inhibitor of dynamin I with respect to GTP and a competitive inhibitor with respect to L-phosphatidylserine Mus musculus
3.6.5.5 methyl 2-phenyl-2-(2-piperidyl)acetate methylphenidate Mus musculus
3.6.5.5 myristyl trimethyl ammonium bromide standard inhibitor of dynamin I Mus musculus
3.6.5.5 N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonyl-benzamide tiapride Mus musculus
3.6.5.5 N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine fluoxetine Mus musculus
3.6.5.5 N-methyl-9,10-ethanoanthracene-9(10H)-propanamine maprotiline Mus musculus
3.6.5.5 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide sulpiride Mus musculus
3.6.5.5 sertraline a mixed type inhibitor with respect to both GTP and L-phosphatidylserine Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.5.5 0.0253
-
GTP in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.5 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.5.5 TALON metal affinity resin column chromatography and MonoQ column chroamtography Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.5.5 neuron neuronal dynamin I plays a critical role in the recycling of synaptic vesicles, and thus in nervous system function Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.5 GTP + H2O
-
Mus musculus GDP + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.6.5.5 Dyn I
-
Mus musculus
3.6.5.5 dynamin I GTPase
-
Mus musculus
3.6.5.5 dynamin I guanosine triphosphatase
-
Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.6.5.5 0.0073
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus sertraline
3.6.5.5 0.0147
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus fluvoxamine
3.6.5.5 0.0211
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus N-methyl-9,10-ethanoanthracene-9(10H)-propanamine
3.6.5.5 0.0234
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidine
3.6.5.5 0.0241
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus myristyl trimethyl ammonium bromide
3.6.5.5 0.0299
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
3.6.5.5 0.0334
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine
3.6.5.5 0.0372
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
3.6.5.5 0.0472
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
3.6.5.5 0.064
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonyl-benzamide
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus methyl 2-phenyl-2-(2-piperidyl)acetate
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 5H-dibenz[b,f]azepine-5-carboxamide
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus (1R,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide
3.6.5.5 0.1
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C Mus musculus 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro[2]benzofuran-5-carbonitrile