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Literature summary extracted from

  • Lemeire, E.; Borovsky, D.; Van Camp, J.; Smagghe, G.
    Effect of Ace inhibitors and TMOF on growth, development, and trypsin activity of larval Spodoptera littoralis (2008), Arch. Insect Biochem. Physiol., 69, 199-208.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 captopril i.e. D-3-mercapto-2-methyl-propionyl-L-proline, 80.5% inhibition at 0.005 mg/mg in L6 larvae Spodoptera littoralis
3.4.15.1 enalapril i.e. ((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline, 74.9% inhibition at 0.005 mg/mg in L6 larvae Spodoptera littoralis
3.4.15.1 lisinopril i.e. [(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline Spodoptera littoralis
3.4.21.4 captopril feeding angiotensin converting enzyme inhibitor captopril down-regulates trypsin activity in the larval gut, injecting third instar larvae with a combination of Aedes aegypti trypsin-modulating oostatic factor and captopril downregulates trypsin biosynthesis in the larval gut Spodoptera littoralis
3.4.21.4 enalapril feeding angiotensin converting enzyme inhibitor enalapril down-regulates trypsin activity in the larval gut Spodoptera littoralis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Spodoptera littoralis
-
 angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 additional information Spodoptera littoralis ACE may influence trypsin biosynthesis in the larval gut by interacting with a trypsin-modulating oostatic factor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Spodoptera littoralis
-
 cotton leafworm
-
3.4.21.4 Spodoptera littoralis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 gut
-
 Spodoptera littoralis
-
3.4.15.1 hemolymph
-
 Spodoptera littoralis
-
3.4.15.1 larva
-
 Spodoptera littoralis
-
3.4.21.4 gut
-
 Spodoptera littoralis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 2-aminobenzoyl-L-Phe-L-Arg-L-Lys-2,4-dinitrophenyl-L-Pro + H2O
-
 Spodoptera littoralis ?
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Spodoptera littoralis angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 additional information ACE may influence trypsin biosynthesis in the larval gut by interacting with a trypsin-modulating oostatic factor Spodoptera littoralis ?
-
 ?
3.4.21.4 N-alpha-benzoyl-L-Arg-4-nitroanilide + H2O
-
 Spodoptera littoralis N-alpha-benzoyl-L-Arg + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Spodoptera littoralis
3.4.15.1 angiotensin converting enzyme
-
 Spodoptera littoralis
3.4.15.1 peptidyl dipeptidase A
-
 Spodoptera littoralis