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Literature summary extracted from
- Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyrate with water-soluble tetrazolium salt (2008), Anal. Sci., 24, 1057-1060.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | captopril | - |
Oryctolagus cuniculus |  |
| 3.4.15.1 | L-Val-L-Tyr | - |
Oryctolagus cuniculus | |
| 3.4.15.1 | lisinopril | - |
Oryctolagus cuniculus | |
| 3.4.15.1 | Tokuho A | - |
Oryctolagus cuniculus | |
| 3.4.15.1 | Tokuho B | - |
Oryctolagus cuniculus | |
| 3.4.15.1 | Tokuho C | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | Oryctolagus cuniculus | - |
angiotensin II + L-His-L-Leu | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | lung | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | 3-hydroxybutyrylglycyl-glycyl-glycine + H2O | - |
Oryctolagus cuniculus | 3-hydroxybutyrylglycine + Gly-Gly | - |
? | |
| 3.4.15.1 | angiotensin I + H2O | - |
Oryctolagus cuniculus | angiotensin II + L-His-L-Leu | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Oryctolagus cuniculus |
| 3.4.15.1 | angiotensin I-converting enzyme | - |
Oryctolagus cuniculus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.00000057 | - |
using 3-hydroxybutyrylglycyl-glycyl-glycine as substrate, at 37°C | Oryctolagus cuniculus | lisinopril | |
| 3.4.15.1 | 0.00000687 | - |
using 3-hydroxybutyrylglycyl-glycyl-glycine as substrate, at 37°C | Oryctolagus cuniculus | captopril | |
| 3.4.15.1 | 0.02956 | - |
using 3-hydroxybutyrylglycyl-glycyl-glycine as substrate, at 37°C | Oryctolagus cuniculus | L-Val-L-Tyr | |
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