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Literature summary extracted from

  • Mao, K.; Kobayashi, S.; Jaffer, Z.M.; Huang, Y.; Volden, P.; Chernoff, J.; Liang, Q.
    Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes (2008), J. Mol. Cell. Cardiol., 44, 429-434.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.1 beta-adrenergic agonist isopreterenol
-
 Rattus norvegicus
2.7.11.1 endothelin-1
-
 Rattus norvegicus
2.7.11.1 Insulin
-
 Rattus norvegicus
2.7.11.1 insulin-like growth factor 1
-
 Rattus norvegicus
2.7.11.1 phenylephrine
-
 Rattus norvegicus
2.7.11.1 phorbol 12-myristate 13-acetate
-
 Rattus norvegicus
2.7.11.1 platelet-derived growth factor
-
 Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 expressed in Escherichia coli as a GST-fusion protein Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.1 additional information Akt signaling is impaired by Pak1 gene silencing or targeted deletion Rattus norvegicus
2.7.11.1 additional information Pak1 overexpression in neonatal rat ventricular cardiomyocytes is able to reduce cardiotoxicity of doxorubicin (DOX), an anticancer drug that can kill neonatal rat ventricular cardiomyocytes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 LY294002 PI3K inhibitor Rattus norvegicus
2.7.11.1 wortmanin PI3K inhibitor Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Mus musculus P07564
-
-
2.7.11.1 Rattus norvegicus P35465
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 cardiac myocyte
-
 Rattus norvegicus
-
2.7.11.1 heart
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.1 additional information
-
 Cardiac Pak1 activity is markedly increased by transverse aortic constriction in both C57BL/6 and FVBN mice Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + Akt (MBP) purified Pak1 can directly phosphorylate Akt only at Ser473, suggesting that Pak1 may be a relevant PDK2 responsible for AKT Ser473 phosphorylation in cardiomyocytes Rattus norvegicus ADP + phosphorylated-Akt
-
 ?
2.7.11.1 ATP + myelin basic protein (MBP)
-
 Rattus norvegicus ADP + phosphorylated-myelin basic protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 P21-activated kinase-1
-
 Rattus norvegicus
2.7.11.1 P21-activated kinase-1
-
 Mus musculus
2.7.11.1 Pak1
-
 Rattus norvegicus
2.7.11.1 Pak1
-
 Mus musculus
2.7.11.1 PDK2
-
 Rattus norvegicus
2.7.11.1 phosphoinositide-dependent protein kinase-2
-
 Rattus norvegicus
2.7.11.1 phosphoinositide-dependent protein kinase-2
-
 Mus musculus