Literature summary extracted from

Tovey, S.C.; Dedos, S.G.; Taylor, E.J.; Church, J.E.; Taylor, C.W.
Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP (2008), J. Cell Biol., 183, 297-311.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
4.6.1.1	isoproterenol	-	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
4.6.1.1	transient expression of tagged isozyme AC3 in HEK-PR1 cells, AC6 forms complexes with the IP3 R2 receptor	Homo sapiens
4.6.1.1	transient expression of tagged isozyme AC6 in HEK-PR1 cells	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.6.1.1	2',5'-dideoxyadenosine	massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine; massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine	Homo sapiens
4.6.1.1	SQ 22536	i.e. 9-(tetrahydro-29-furyl)adenine, massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine; i.e. 9-(tetrahydro-29-furyl)adenine, massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4.6.1.1	ATP	Homo sapiens	the reaction is part of the cAMP signaling pathways, overview	3',5'-cyclic-AMP + diphosphate	-	?
4.6.1.1	ATP	Homo sapiens	the reaction is part of the cAMP signaling pathways, overview	3',5'-cyclic-AMP + diphosphate	the intimate association between IP3R2 receptor and isozyme AC6 allows cAMP to pass directly from adenylate cyclase to IP3R in a manner analogous to substrate channeling in enzyme complexes, overview	?
4.6.1.1	additional information	Homo sapiens	potentiation of IP3-evoked Ca2+-signals by PTH specifically requires AC6 and IP3R2 receptor, the muscarinic receptors, that alone evoke Ca2+ release, are distributed differently to those that release Ca2+ in synergy with cAMP, overview. Focal inhibition of the enzyme more effectively inhibits Ca2+ signaling than global inhibition	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.6.1.1	Homo sapiens	O43306	isozyme AC6	-
4.6.1.1	Homo sapiens	O60266	isozyme AC3; isozyme AC3	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.6.1.1	ATP	-	Homo sapiens	3',5'-cyclic-AMP + diphosphate	-	?
4.6.1.1	ATP	the reaction is part of the cAMP signaling pathways, overview	Homo sapiens	3',5'-cyclic-AMP + diphosphate	-	?
4.6.1.1	ATP	the reaction is part of the cAMP signaling pathways, overview	Homo sapiens	3',5'-cyclic-AMP + diphosphate	the intimate association between IP3R2 receptor and isozyme AC6 allows cAMP to pass directly from adenylate cyclase to IP3R in a manner analogous to substrate channeling in enzyme complexes, overview	?
4.6.1.1	additional information	potentiation of IP3-evoked Ca2+-signals by PTH specifically requires AC6 and IP3R2 receptor, the muscarinic receptors, that alone evoke Ca2+ release, are distributed differently to those that release Ca2+ in synergy with cAMP, overview. Focal inhibition of the enzyme more effectively inhibits Ca2+ signaling than global inhibition	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
4.6.1.1	AC3	-	Homo sapiens
4.6.1.1	AC6	-	Homo sapiens
4.6.1.1	type 3 adenylyl cyclase	-	Homo sapiens
4.6.1.1	type 6 adenylyl cyclase	-	Homo sapiens

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Release 2023.1 (January 2023)