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Literature summary extracted from
- Interaction between bisphenol derivatives and protein disulphide isomerase (PDI) and inhibition of PDI functions: requirement of chemical structure for binding to PDI (2008), J. Biochem., 144, 335-342.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.3.4.1 | - |
Rattus norvegicus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | C398A/C401A | 90% residual isomerase activity | Rattus norvegicus |
| 5.3.4.1 | C54A/C57A | 30% residual isomerase activity | Rattus norvegicus |
| 5.3.4.1 | C54A/C57A/C398A/C401A | 15% residual isomerase activity | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.4.1 | 1,1-bis(4-hydroxyphenyl)ethane | i.e.bisphenol E, 15% inhibition at 0.0125 mM | Rattus norvegicus |  |
| 5.3.4.1 | 1,3-diphenylpropane | 8% inhibition at 0.0125 mM | Rattus norvegicus | |
| 5.3.4.1 | 2,2-bis(4-hydroxyphenyl)propane | i.e. bisphenol A, 30% inhibition at 0.0125 mM | Rattus norvegicus | |
| 5.3.4.1 | 3,3',5-triiodo-L-thyronine | 30% inhibition at 0.0125 mM | Rattus norvegicus | |
| 5.3.4.1 | 4,4'-methylenebisphenol | 12% inhibition at 0.0125 mM | Rattus norvegicus | |
| 5.3.4.1 | 4-alpha-cumylphenol | 18% inhibition at 0.0125 mM | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.4.1 | Rattus norvegicus | - |
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