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Literature summary extracted from

  • Hink, U.; Daiber, A.; Kayhan, N.; Trischler, J.; Kraatz, C.; Oelze, M.; Mollnau, H.; Wenzel, P.; Vahl, C.F.; Ho, K.K.; Weiner, H.; Munzel, T.
    Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels (2007), J. Am. Coll. Cardiol., 50, 2226-2232.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 benomyl
-
 Homo sapiens
1.2.1.3 nitroglycerin intravenous nitroglycerin treatment inhibits ALDH-2 activity, activity can be restored using dithiothreitol Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens P05091
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 blood vessel
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 2-hydroxy-3-nitrobenzaldehyde + NAD+ + H2O
-
 Homo sapiens 2-hydroxy-3-nitrobenzoic acid + NADH + H+
-
 ?
1.2.1.3 benzaldehyde + NAD+ + H2O
-
 Homo sapiens benzoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH-2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens