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Literature summary extracted from
- Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries (2007), Phytother. Res., 21, 805-816.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | (+)-gallocatechin-3-O-gallate | GCG, tyrosinase inhibitor | Agaricus bisporus |  |
| 1.14.18.1 | (+)-gallocatechin-3-O-gallate | GCG, tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | (+)-gallocatechin-3-O-gallate | GCG, tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | (+)-gallocatechin-3-O-gallate | GCG, tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | (-)-epicatechin-3-O-gallate | ECG, tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | (-)-epicatechin-3-O-gallate | ECG, tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | (-)-epicatechin-3-O-gallate | ECG, tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | (-)-epicatechin-3-O-gallate | ECG, tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | (-)-epigallocatechin-3-O-gallate | EGCG, tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | (-)-epigallocatechin-3-O-gallate | EGCG, tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | (-)-epigallocatechin-3-O-gallate | EGCG, tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | (-)-epigallocatechin-3-O-gallate | EGCG, tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | 3,4-dihydroxycinnamic acid | noncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | 4-hydroxy-3-methoxycinnamic acid | noncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | 5-hydroxymethyl-2-furfural | noncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | 9-hydroxy-4-methoxypsoralen | noncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | Agaritine | uncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | aloesin | noncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | anacardic acid | competitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | Anisaldehyde | noncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | Anisic acid | uncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | arbutin | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | arbutin | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | arbutin | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | arbutin | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | ascorbic acid | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | ascorbic acid | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | ascorbic acid | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | ascorbic acid | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | azelaic acid | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | azelaic acid | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | azelaic acid | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | azelaic acid | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | catechin | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | catechin | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | catechin | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | catechin | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | cumic acid | noncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | cuminaldehyde | noncompetitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | glabridine | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | glabridine | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | glabridine | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | glabridine | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | glyasperin C | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | glyasperin C | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | glyasperin C | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | glyasperin C | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | glycolic acid | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | glycolic acid | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | glycolic acid | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | glycolic acid | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | hydroquinone | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | hydroquinone | HQ, tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | hydroquinone | HQ, tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | hydroquinone | HQ, tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | hydroxyanisole | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | hydroxyanisole | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | hydroxyanisole | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | hydroxyanisole | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | kaempferol | competitive inhibition | Agaricus bisporus | |
| 1.14.18.1 | kojic acid | tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | kojic acid | tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | kojic acid | tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | kojic acid | tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | monobenzyl hydroquinone | benoquin, PBP, tyrosinase inhibitor | Agaricus bisporus | |
| 1.14.18.1 | monobenzyl hydroquinone | benoquin, PBP, tyrosinase inhibitor | Beta vulgaris | |
| 1.14.18.1 | monobenzyl hydroquinone | benoquin, PBP, tyrosinase inhibitor | Neurospora crassa | |
| 1.14.18.1 | monobenzyl hydroquinone | benoquin, PBP, tyrosinase inhibitor | Streptomyces glaucescens | |
| 1.14.18.1 | oxyresveratrol | - |
Agaricus bisporus | |
| 1.14.18.1 | p-coumaric acid | mixed inhibition | Agaricus bisporus | |
| 1.14.18.1 | trans-cinnamaldehyde | competitive inhibition | Agaricus bisporus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 13400 | - |
two subunits | Agaricus bisporus |
| 1.14.18.1 | 30900 | - |
- |
Streptomyces glaucescens |
| 1.14.18.1 | 40000 | - |
- |
Beta vulgaris |
| 1.14.18.1 | 43000 | - |
two subunits | Agaricus bisporus |
| 1.14.18.1 | 46000 | - |
- |
Neurospora crassa |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
| 1.14.18.1 | Beta vulgaris | - |
- |
- |
| 1.14.18.1 | Neurospora crassa | - |
- |
- |
| 1.14.18.1 | Streptomyces glaucescens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | dimer | - |
Agaricus bisporus |
| 1.14.18.1 | monomer | - |
Neurospora crassa |
| 1.14.18.1 | monomer | 1 * 30900 | Streptomyces glaucescens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | polyphenol oxidase | - |
Beta vulgaris |
| 1.14.18.1 | polyphenol oxidase | - |
Neurospora crassa |
| 1.14.18.1 | polyphenol oxidase | - |
Agaricus bisporus |
| 1.14.18.1 | polyphenol oxidase | - |
Streptomyces glaucescens |
| 1.14.18.1 | tyrosinase | - |
Beta vulgaris |
| 1.14.18.1 | tyrosinase | - |
Neurospora crassa |
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
| 1.14.18.1 | tyrosinase | - |
Streptomyces glaucescens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | 0.0001 | - |
- |
Agaricus bisporus | anacardic acid | |
| 1.14.18.1 | 0.001 | - |
- |
Agaricus bisporus | oxyresveratrol | |
| 1.14.18.1 | 0.03 | - |
- |
Agaricus bisporus | Agaritine | |
| 1.14.18.1 | 0.034 | - |
competitive inhibition | Agaricus bisporus | (-)-epigallocatechin-3-O-gallate | |
| 1.14.18.1 | 0.035 | - |
competitive inhibition | Agaricus bisporus | (+)-gallocatechin-3-O-gallate | |
| 1.14.18.1 | 0.04 | - |
- |
Agaricus bisporus | arbutin | |
| 1.14.18.1 | 0.05 | - |
- |
Agaricus bisporus | cuminaldehyde | |
| 1.14.18.1 | 0.1 | - |
- |
Agaricus bisporus | aloesin | |
| 1.14.18.1 | 0.2 | - |
- |
Agaricus bisporus | 9-hydroxy-4-methoxypsoralen | |
| 1.14.18.1 | 0.23 | - |
- |
Agaricus bisporus | kaempferol | |
| 1.14.18.1 | 0.26 | - |
- |
Agaricus bisporus | cumic acid | |
| 1.14.18.1 | 0.38 | - |
- |
Agaricus bisporus | Anisaldehyde | |
| 1.14.18.1 | 0.68 | - |
- |
Agaricus bisporus | Anisic acid | |
| 1.14.18.1 | 0.85 | - |
- |
Agaricus bisporus | trans-cinnamaldehyde | |
| 1.14.18.1 | 0.97 | - |
- |
Agaricus bisporus | 3,4-dihydroxycinnamic acid | |
| 1.14.18.1 | 0.97 | - |
- |
Agaricus bisporus | 4-hydroxy-3-methoxycinnamic acid | |
| 1.14.18.1 | 0.98 | - |
- |
Agaricus bisporus | 5-hydroxymethyl-2-furfural | |
| 1.14.18.1 | 3.65 | - |
- |
Agaricus bisporus | p-coumaric acid | |
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