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Literature summary extracted from

  • Schmutzler, C.; Bacinski, A.; Gotthardt, I.; Huhne, K.; Ambrugger, P.; Klammer, H.; Schlecht, C.; Hoang-Vu, C.; Grueters, A.; Wuttke, W.; Jarry, H.; Koehrle, J.
    The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase (2007), Endocrinology, 148, 2835-2844.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.8 benzophenone 2 inactivation is prevented by iodideone of the most potent inhibitors of TPO Homo sapiens
1.11.1.8 bisphenol A
-
 Homo sapiens
1.11.1.8 F21388
-
 Homo sapiens
1.11.1.8 H2O2 inactivation is prevented by iodide Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.8 Homo sapiens
-
 recombinant
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.8 additional information recombinant TPO stably transfected into the human follicular thyroid carcinoma cell line FTC-238 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.8 iodide + H2O2
-
 Homo sapiens iodine + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.8 hrTPO
-
 Homo sapiens