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Literature summary extracted from
- A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium (2007), Chem. Biol., 14, 1334-1346.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.14.17 | additional information | erg1 silencing in Hypholoma sublateritium, by expression of constructions using the gdh promoter of Agaricus bisporus, results in an ergosterol-dependnet phenotype for full growth, overexpression of erg1 results in 32%-97% increment of clavaric acid production, overview | Hypholoma sublateritium |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.17 | Fe2+ | a cytochrome P450 enzyme | Hypholoma sublateritium |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.17 | squalene + AH2 + O2 | Hypholoma sublateritium | oxidosqualene or dioxidosqualene appears to be the branching point for primary metabolism and secondary metabolites in basidiomycetes | (S)-squalene-2,3-epoxide + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.17 | Hypholoma sublateritium | - |
a basidiomycete, gene erg1 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.17 | squalene + AH2 + O2 | - |
Hypholoma sublateritium | (S)-squalene-2,3-epoxide + A + H2O | - |
? | |
| 1.14.14.17 | squalene + AH2 + O2 | oxidosqualene or dioxidosqualene appears to be the branching point for primary metabolism and secondary metabolites in basidiomycetes | Hypholoma sublateritium | (S)-squalene-2,3-epoxide + A + H2O | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.17 | cytochrome P450 | required | Hypholoma sublateritium | |
| 1.14.14.17 | FAD | required | Hypholoma sublateritium | |
| 1.14.14.17 | NADPH | required | Hypholoma sublateritium | |
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Release 2023.1 (January 2023)
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