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Literature summary extracted from

  • Li, L.; Porter, T.D.
    Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase (2007), Arch. Biochem. Biophys., 461, 76-84.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.17 additional information in hepatocytes deficent for NADPH-cytochrome P450 reductase, the second microsomal reductase retains about 40% of the full activity for conversion of squalene to 2,3(s)-oxidosqualene with squalene monooxygenase, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.17 endoplasmic reticulum
-
 Mus musculus 5783
-
1.14.14.17 membrane
-
 Mus musculus 16020
-
1.14.14.17 microsome
-
 Mus musculus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.14.17 64000
-
 x * 64000 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.17 additional information Mus musculus squalene epoxidase interacts with NADPH-cytochrome P450 reductase and a second microsomal reductase for the conversion of squalene to 2,3(s)-oxidosqualene and to lanosterol in the cholesterol biosynthesis pathway, overview ?
-
 ?
1.14.14.17 squalene + AH2 + O2 Mus musculus
-
 (S)-squalene-2,3-epoxide + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Mus musculus
-
-
-
1.14.14.17 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.4 liver hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase Mus musculus
-
1.14.14.17 hepatocyte primary Mus musculus
-
1.14.14.17 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.17 additional information squalene epoxidase interacts with NADPH-cytochrome P450 reductase and a second microsomal reductase for the conversion of squalene to 2,3(s)-oxidosqualene and to lanosterol in the cholesterol biosynthesis pathway, overview Mus musculus ?
-
 ?
1.14.14.17 squalene + AH2 + O2
-
 Mus musculus (S)-squalene-2,3-epoxide + A + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.14.17 ? x * 64000 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.17 FAD
-
 Mus musculus