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Literature summary extracted from

  • Kornhuber, J.; Tripal, P.; Reichel, M.; Terfloth, L.; Bleich, S.; Wiltfang, J.; Gulbins, E.
    Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model (2008), J. Med. Chem., 51, 219-237.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 amlodipine
-
Homo sapiens
3.1.4.12 amlodipine
-
Rattus norvegicus
3.1.4.12 astemizole
-
Homo sapiens
3.1.4.12 astemizole
-
Rattus norvegicus
3.1.4.12 benztropine
-
Homo sapiens
3.1.4.12 benztropine
-
Rattus norvegicus
3.1.4.12 bepridil
-
Homo sapiens
3.1.4.12 bepridil
-
Rattus norvegicus
3.1.4.12 camylofin
-
Homo sapiens
3.1.4.12 camylofin
-
Rattus norvegicus
3.1.4.12 chlorprothixene
-
Homo sapiens
3.1.4.12 chlorprothixene
-
Rattus norvegicus
3.1.4.12 clomiphene
-
Homo sapiens
3.1.4.12 clomiphene
-
Rattus norvegicus
3.1.4.12 cloperastine
-
Homo sapiens
3.1.4.12 cloperastine
-
Rattus norvegicus
3.1.4.12 cyclobenzaprine
-
Homo sapiens
3.1.4.12 cyclobenzaprine
-
Rattus norvegicus
3.1.4.12 cyproheptadine
-
Homo sapiens
3.1.4.12 cyproheptadine
-
Rattus norvegicus
3.1.4.12 doxepine
-
Homo sapiens
3.1.4.12 doxepine
-
Rattus norvegicus
3.1.4.12 drofenine
-
Homo sapiens
3.1.4.12 drofenine
-
Rattus norvegicus
3.1.4.12 fendiline
-
Homo sapiens
3.1.4.12 fendiline
-
Rattus norvegicus
3.1.4.12 fluoxetine
-
Homo sapiens
3.1.4.12 fluoxetine
-
Rattus norvegicus
3.1.4.12 maprotiline
-
Homo sapiens
3.1.4.12 maprotiline
-
Rattus norvegicus
3.1.4.12 additional information ASM detachment from lysosomal membranes, caused by weak bases inhibit the enzyme, usage of structure-property-activity relation model in inhibitor screening, overview, no inhibition of ASM by dicyclomine, diphenhydramine, diphenylpyraline, donepezil, lercanidipine, mebeverine, memantine, oxymetazoline, oxyphencyclimine, pyrilamine, triprolidine, and xylometazoline Homo sapiens
3.1.4.12 additional information ASM detachment from lysosomal membranes caused by weak bases inhibit the enzyme, usage of structure-property-activity relation model in inhibitor screening, overview, no inhibition of ASM by dicyclomine, diphenhydramine, diphenylpyraline, donepezil, lercanidipine, mebeverine, memantine, oxymetazoline, oxyphencyclimine, pyrilamine, triprolidine, and xylometazoline Rattus norvegicus
3.1.4.12 norfluoxetine
-
Homo sapiens
3.1.4.12 norfluoxetine
-
Rattus norvegicus
3.1.4.12 nortriptyline
-
Homo sapiens
3.1.4.12 nortriptyline
-
Rattus norvegicus
3.1.4.12 paroxetine
-
Homo sapiens
3.1.4.12 paroxetine
-
Rattus norvegicus
3.1.4.12 pimethixene
-
Homo sapiens
3.1.4.12 pimethixene
-
Rattus norvegicus
3.1.4.12 promazine
-
Homo sapiens
3.1.4.12 promazine
-
Rattus norvegicus
3.1.4.12 Promethazine
-
Homo sapiens
3.1.4.12 Promethazine
-
Rattus norvegicus
3.1.4.12 protriptyline
-
Homo sapiens
3.1.4.12 protriptyline
-
Rattus norvegicus
3.1.4.12 sertraline
-
Homo sapiens
3.1.4.12 sertraline
-
Rattus norvegicus
3.1.4.12 suloctidil
-
Homo sapiens
3.1.4.12 suloctidil
-
Rattus norvegicus
3.1.4.12 terfenadine
-
Homo sapiens
3.1.4.12 terfenadine
-
Rattus norvegicus
3.1.4.12 triflupromazine
-
Homo sapiens
3.1.4.12 triflupromazine
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 lysosomal membrane inner lysosomal membrane, detachment caused by weak bases inhibits the enzyme Homo sapiens 5765
-
3.1.4.12 lysosomal membrane inner lysosomal membrane, detachment caused by weak bases inhibits the enzyme Rattus norvegicus 5765
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O Rattus norvegicus
-
N-acylsphingosine + choline phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-
3.1.4.12 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 brain
-
Homo sapiens
-
3.1.4.12 H4 neuroglioma cell
-
Homo sapiens
-
3.1.4.12 neuroglioma cell
-
Homo sapiens
-
3.1.4.12 PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
Homo sapiens
3.1.4.12 acid sphingomyelinase
-
Rattus norvegicus
3.1.4.12 ASM
-
Homo sapiens
3.1.4.12 ASM
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
assay at Homo sapiens
3.1.4.12 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 7.5
-
assay at Homo sapiens
3.1.4.12 7.5
-
assay at Rattus norvegicus