EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | amlodipine | - |
Homo sapiens | |
3.1.4.12 | amlodipine | - |
Rattus norvegicus | |
3.1.4.12 | astemizole | - |
Homo sapiens | |
3.1.4.12 | astemizole | - |
Rattus norvegicus | |
3.1.4.12 | benztropine | - |
Homo sapiens | |
3.1.4.12 | benztropine | - |
Rattus norvegicus | |
3.1.4.12 | bepridil | - |
Homo sapiens | |
3.1.4.12 | bepridil | - |
Rattus norvegicus | |
3.1.4.12 | camylofin | - |
Homo sapiens | |
3.1.4.12 | camylofin | - |
Rattus norvegicus | |
3.1.4.12 | chlorprothixene | - |
Homo sapiens | |
3.1.4.12 | chlorprothixene | - |
Rattus norvegicus | |
3.1.4.12 | clomiphene | - |
Homo sapiens | |
3.1.4.12 | clomiphene | - |
Rattus norvegicus | |
3.1.4.12 | cloperastine | - |
Homo sapiens | |
3.1.4.12 | cloperastine | - |
Rattus norvegicus | |
3.1.4.12 | cyclobenzaprine | - |
Homo sapiens | |
3.1.4.12 | cyclobenzaprine | - |
Rattus norvegicus | |
3.1.4.12 | cyproheptadine | - |
Homo sapiens | |
3.1.4.12 | cyproheptadine | - |
Rattus norvegicus | |
3.1.4.12 | doxepine | - |
Homo sapiens | |
3.1.4.12 | doxepine | - |
Rattus norvegicus | |
3.1.4.12 | drofenine | - |
Homo sapiens | |
3.1.4.12 | drofenine | - |
Rattus norvegicus | |
3.1.4.12 | fendiline | - |
Homo sapiens | |
3.1.4.12 | fendiline | - |
Rattus norvegicus | |
3.1.4.12 | fluoxetine | - |
Homo sapiens | |
3.1.4.12 | fluoxetine | - |
Rattus norvegicus | |
3.1.4.12 | maprotiline | - |
Homo sapiens | |
3.1.4.12 | maprotiline | - |
Rattus norvegicus | |
3.1.4.12 | additional information | ASM detachment from lysosomal membranes, caused by weak bases inhibit the enzyme, usage of structure-property-activity relation model in inhibitor screening, overview, no inhibition of ASM by dicyclomine, diphenhydramine, diphenylpyraline, donepezil, lercanidipine, mebeverine, memantine, oxymetazoline, oxyphencyclimine, pyrilamine, triprolidine, and xylometazoline | Homo sapiens | |
3.1.4.12 | additional information | ASM detachment from lysosomal membranes caused by weak bases inhibit the enzyme, usage of structure-property-activity relation model in inhibitor screening, overview, no inhibition of ASM by dicyclomine, diphenhydramine, diphenylpyraline, donepezil, lercanidipine, mebeverine, memantine, oxymetazoline, oxyphencyclimine, pyrilamine, triprolidine, and xylometazoline | Rattus norvegicus | |
3.1.4.12 | norfluoxetine | - |
Homo sapiens | |
3.1.4.12 | norfluoxetine | - |
Rattus norvegicus | |
3.1.4.12 | nortriptyline | - |
Homo sapiens | |
3.1.4.12 | nortriptyline | - |
Rattus norvegicus | |
3.1.4.12 | paroxetine | - |
Homo sapiens | |
3.1.4.12 | paroxetine | - |
Rattus norvegicus | |
3.1.4.12 | pimethixene | - |
Homo sapiens | |
3.1.4.12 | pimethixene | - |
Rattus norvegicus | |
3.1.4.12 | promazine | - |
Homo sapiens | |
3.1.4.12 | promazine | - |
Rattus norvegicus | |
3.1.4.12 | Promethazine | - |
Homo sapiens | |
3.1.4.12 | Promethazine | - |
Rattus norvegicus | |
3.1.4.12 | protriptyline | - |
Homo sapiens | |
3.1.4.12 | protriptyline | - |
Rattus norvegicus | |
3.1.4.12 | sertraline | - |
Homo sapiens | |
3.1.4.12 | sertraline | - |
Rattus norvegicus | |
3.1.4.12 | suloctidil | - |
Homo sapiens | |
3.1.4.12 | suloctidil | - |
Rattus norvegicus | |
3.1.4.12 | terfenadine | - |
Homo sapiens | |
3.1.4.12 | terfenadine | - |
Rattus norvegicus | |
3.1.4.12 | triflupromazine | - |
Homo sapiens | |
3.1.4.12 | triflupromazine | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.12 | lysosomal membrane | inner lysosomal membrane, detachment caused by weak bases inhibits the enzyme | Homo sapiens | 5765 | - |
3.1.4.12 | lysosomal membrane | inner lysosomal membrane, detachment caused by weak bases inhibits the enzyme | Rattus norvegicus | 5765 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | Homo sapiens | - |
N-acylsphingosine + choline phosphate | - |
? | |
3.1.4.12 | sphingomyelin + H2O | Rattus norvegicus | - |
N-acylsphingosine + choline phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Homo sapiens | - |
- |
- |
3.1.4.12 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | brain | - |
Homo sapiens | - |
3.1.4.12 | H4 neuroglioma cell | - |
Homo sapiens | - |
3.1.4.12 | neuroglioma cell | - |
Homo sapiens | - |
3.1.4.12 | PC-12 cell | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
3.1.4.12 | sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | acid sphingomyelinase | - |
Homo sapiens |
3.1.4.12 | acid sphingomyelinase | - |
Rattus norvegicus |
3.1.4.12 | ASM | - |
Homo sapiens |
3.1.4.12 | ASM | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 37 | - |
assay at | Homo sapiens |
3.1.4.12 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 7.5 | - |
assay at | Homo sapiens |
3.1.4.12 | 7.5 | - |
assay at | Rattus norvegicus |