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Literature summary extracted from

  • Riviere, G.; Michaud, A.; Corradi, H.R.; Sturrock, E.D.; Ravi Acharya, K.; Cogez, V.; Bohin, J.P.; Vieau, D.; Corvol, P.
    Characterization of the first angiotensin-converting like enzyme in bacteria: Ancestor ACE is already active (2007), Gene, 399, 81-90.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.15.1 expression in CHO-K1 cells Xanthomonas axonopodis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 captopril
-
 Xanthomonas axonopodis
3.4.15.1 delaprilat weak Xanthomonas axonopodis
3.4.15.1 EDTA
-
 Xanthomonas axonopodis
3.4.15.1 enalaprilat
-
 Xanthomonas axonopodis
3.4.15.1 fosinoprilat
-
 Xanthomonas axonopodis
3.4.15.1 lisinopril weak Xanthomonas axonopodis
3.4.15.1 perindoprilat weak Xanthomonas axonopodis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.15.1 periplasmic space XcACE is constituvely expressed and is likely to be secreted and further localised in the periplasmic space Xanthomonas axonopodis 42597
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.15.1 Zinc XcACE activity depends on zinc binding. Hydrolysis of 7-methoxycoumarin-4-yl-diacetyl-SDKP-N3 (2,4-dinitrophenyl)L-2,3-diaminopropionyl-OH is abolished after zinc chelation with EDTA and dialysis but is restored by zinc addition Xanthomonas axonopodis

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Xanthomonas axonopodis
-
 pv. citri
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Xanthomonas axonopodis angiotensin II + His-Leu
-
 ?
3.4.15.1 hippuryl-His-Leu + H2O
-
 Xanthomonas axonopodis hippuric acid + His-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 XcACE
-
 Xanthomonas axonopodis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.00003
-
-
 Xanthomonas axonopodis fosinoprilat
3.4.15.1 0.00016
-
-
 Xanthomonas axonopodis captopril