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Literature summary extracted from

  • Yasuda, S.; Idell, S.; Fu, J.; Carter, G.; Snow, R.; Liu, M.C.
    Cigarette smoke toxicants as substrates and inhibitors for human cytosolic SULTs (2007), Toxicol. Appl. Pharmacol., 221, 13-20.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol Homo sapiens
2.8.2.1 4-aminobiphenyl i.e. 4-ABP, mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol Homo sapiens
2.8.2.1 N-Hydroxy-4-aminobiphenyl i.e. N-OH-4-ABP, mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 17beta-estradiol Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 2-naphthylamine Homo sapiens
-
 adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + caffeic acid Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl Homo sapiens
-
 adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + phenol Homo sapiens
-
 adenosine 3',5'-bisphosphate + phenyl sulfate
-
 ?
2.8.2.1 additional information Homo sapiens SULT1A1 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview ?
-
 ?
2.8.2.1 additional information Homo sapiens SULT1A2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview ?
-
 ?
2.8.2.1 additional information Homo sapiens SULT1A3 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview ?
-
 ?
2.8.2.1 additional information Homo sapiens SULT1C*2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens O00338 SULT1C*2
-
2.8.2.1 Homo sapiens O43704 SULT1B2
-
2.8.2.1 Homo sapiens P0DMM9 SULT1A3
-
2.8.2.1 Homo sapiens P50225 SULT1A1
-
2.8.2.1 Homo sapiens P50226 SULT1A2
-
2.8.2.1 Homo sapiens Q9BR01 SULT4A1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 artery pulmonary, endothelial cell Homo sapiens
-
2.8.2.1 endothelial cell primary pulmonary artery endothelial cells and lung microvascular endothelial cells Homo sapiens
-
2.8.2.1 Hep-G2 cell human hepatoma cell line, ATCC HB 8065 Homo sapiens
-
2.8.2.1 lung lung microvascular endothelial cells Homo sapiens
-
2.8.2.1 neuron SULT4A1 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.1 0.00009 0.00452 SULT activities with 3-naphthylamine, overview Homo sapiens
2.8.2.1 0.00014 0.00052 SULT activities with N-hydroxy-4-aminobiphenyl, overview Homo sapiens
2.8.2.1 0.00031 0.01201 SULT activities with caffeic acid, overview Homo sapiens
2.8.2.1 0.0066 0.0166 SULT activities with catechol, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 17beta-estradiol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 17beta-estradiol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 17beta-estradiol SULT1A2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 17beta-estradiol SULT1C*2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 2-naphthylamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 2-naphthylamine SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 2-naphthylamine SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 2-naphthylamine SULT1A2 Homo sapiens adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 2-naphthylamine SULT1B2 Homo sapiens adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 2-naphthylamine SULT1C*2 Homo sapiens adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + caffeic acid
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + caffeic acid SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + caffeic acid SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + caffeic acid SULT1A2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + caffeic acid SULT1C*2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + catechol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + catechol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + catechol SULT1A2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + catechol SULT1C*2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl SULT1A2 Homo sapiens adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl SULT1C*2 Homo sapiens adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl-4-amine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + phenyl sulfate
-
 ?
2.8.2.1 additional information SULT1A1 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview Homo sapiens ?
-
 ?
2.8.2.1 additional information SULT1A2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview Homo sapiens ?
-
 ?
2.8.2.1 additional information SULT1A3 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview Homo sapiens ?
-
 ?
2.8.2.1 additional information SULT1C*2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview Homo sapiens ?
-
 ?
2.8.2.1 additional information no activity with caffeic acid, catechol, 17beta-estradiol, N-hydroxy-4-aminobiphenyl, DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1B2 Homo sapiens ?
-
 ?
2.8.2.1 additional information no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A1 Homo sapiens ?
-
 ?
2.8.2.1 additional information no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A2 Homo sapiens ?
-
 ?
2.8.2.1 additional information no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A3 Homo sapiens ?
-
 ?
2.8.2.1 additional information no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1C*2 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 cytosolic sulfotransferase
-
 Homo sapiens
2.8.2.1 neuronal SULT
-
 Homo sapiens
2.8.2.1 SULT1A1
-
 Homo sapiens
2.8.2.1 SULT1A2
-
 Homo sapiens
2.8.2.1 SULT1A3
-
 Homo sapiens
2.8.2.1 SULT1B2
-
 Homo sapiens
2.8.2.1 SULT1C*2
-
 Homo sapiens
2.8.2.1 SULT4A1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 7.5
-
 assay at Homo sapiens