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Literature summary extracted from

  • Humphries, K.M.; Pennypacker, J.K.; Taylor, S.S.
    Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation (2007), J. Biol. Chem., 282, 22072-22079.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 8-bromo-cAMP stimulates Homo sapiens
2.7.11.11 cAMP
-
 Homo sapiens
2.7.11.11 forskolin stimulates the cAMP-dependent enzyme Homo sapiens
2.7.11.11 isoproterenol stimulates Homo sapiens
2.7.11.11 additional information under mild oxidizing conditions, or short exposure to oxidants, forskolin-stimulated PKA activity is enhanced Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 H89
-
 Homo sapiens
2.7.11.11 additional information PKA is inhibited by oxidation via either glutathionylation of Cys199 in the activation loop, or the formation of an internal disulfide bond between Cys199 and Cys343 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.11 mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Homo sapiens
2.7.11.11 additional information in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Homo sapiens redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation, in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + kemptide
-
 Homo sapiens ADP + phospho-kemptide
-
 ?
2.7.11.11 additional information redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation, in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.11 7.2
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Homo sapiens