Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Silva, R.G.; Nunes, J.E.; Canduri, F.; Borges, J.C.; Gava, L.M.; Moreno, F.B.; Basso, L.A.; Santos, D.S.
    Purine nucleoside phosphorylase: a potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases (2007), Curr. Drug Targets, 8, 413-422.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.1 immucillin-H
-
Homo sapiens
2.4.2.1 immucillin-H
-
Plasmodium falciparum
2.4.2.1 immucillin-H
-
Plasmodium lophurae
2.4.2.1 immucillin-H
-
Toxoplasma gondii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.1 0.006
-
guanine recombinant erythrocyte enzyme Homo sapiens
2.4.2.1 0.0078
-
Inosine
-
Bos taurus
2.4.2.1 0.012
-
guanosine recombinant erythrocyte enzyme Homo sapiens
2.4.2.1 0.016
-
7-methylguanosine
-
Bos taurus
2.4.2.1 0.018
-
guanosine
-
Bos taurus
2.4.2.1 0.02
-
deoxyguanosine
-
Bos taurus
2.4.2.1 0.03
-
hypoxanthine recombinant erythrocyte enzyme Homo sapiens
2.4.2.1 0.04
-
Inosine recombinant erythrocyte enzyme Homo sapiens
2.4.2.1 0.053
-
phosphate
-
Bos taurus
2.4.2.1 4
-
phosphate recombinant erythrocyte enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.1 Bos taurus P55859
-
-
2.4.2.1 Homo sapiens P00491
-
-
2.4.2.1 Plasmodium falciparum Q8T9Z7
-
-
2.4.2.1 Plasmodium lophurae
-
-
-
2.4.2.1 Toxoplasma gondii
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.1 erythrocyte
-
Homo sapiens
-
2.4.2.1 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.1 7-methylguanosine + phosphate
-
Bos taurus 7-methylguanine + alpha-D-ribose 1-phosphate
-
?
2.4.2.1 deoxyguanosine + phosphate
-
Bos taurus guanine + alpha-D-deoxyribose 1-phosphate
-
?
2.4.2.1 guanosine + phosphate
-
Homo sapiens guanine + alpha-D-ribose 1-phosphate
-
r
2.4.2.1 guanosine + phosphate
-
Bos taurus guanine + alpha-D-ribose 1-phosphate
-
?
2.4.2.1 inosine + phosphate
-
Homo sapiens hypoxanthine + alpha-D-ribose 1-phosphate
-
r
2.4.2.1 inosine + phosphate
-
Bos taurus hypoxanthine + alpha-D-ribose 1-phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.1 bPNO
-
Bos taurus
2.4.2.1 HsPNO
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.2.1 2 8 guanosine recombinant erythrocyte enzyme Homo sapiens
2.4.2.1 20
-
Inosine
-
Bos taurus
2.4.2.1 48
-
guanine recombinant erythrocyte enzyme Homo sapiens
2.4.2.1 56
-
phosphate recombinant erythrocyte enzyme Homo sapiens
2.4.2.1 56
-
Inosine recombinant erythrocyte enzyme Homo sapiens
2.4.2.1 110
-
hypoxanthine recombinant erythrocyte enzyme Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.1 0.000000072
-
immucillin-H
-
Homo sapiens