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Literature summary extracted from

  • Skidgel, R.A.; Erdoes, E.G.
    Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies (2004), Peptides, 25, 521-525.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 angiotensin I
-
 Homo sapiens
3.4.24.11 bradykinin
-
 Homo sapiens
3.4.24.11 Met5-enkephalin
-
 Homo sapiens
3.4.24.11 neurotensin
-
 Homo sapiens
3.4.24.11 Substance P
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.11 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.11 Leu5-enkephalin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.11 neurotensin + H2O cleaves at Pro10-Tyr11 and Tyr11-Ile12 Homo sapiens ?
-
 ?
3.4.24.11 Substance P + H2O cleaves at Gln6-Phe7, Phe7-Phe8, and Gly9-Leu10 Homo sapiens ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.11 0.022
-
 Met5-enkephalin hydrolysis of Leu5-enkephalin Homo sapiens
3.4.24.11 0.036
-
 angiotensin I hydrolysis of Leu5-enkephalin Homo sapiens
3.4.24.11 0.039
-
 neurotensin hydrolysis of Leu5-enkephalin Homo sapiens
3.4.24.11 0.162
-
 bradykinin hydrolysis of Leu5-enkephalin Homo sapiens
3.4.24.11 0.19
-
 Substance P hydrolysis of Leu5-enkephalin Homo sapiens