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Literature summary extracted from

  • Kruse, M.; Becker, C.; Lottaz, D.; Koehler, D.; Yiallouros, I.; Krell, H.; Sterchi, E.E.; Stoecker, W.
    Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors (2004), Biochem. J., 378, 383-389.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.18 actinonin
-
 Homo sapiens
3.4.24.18 batimastat
-
 Homo sapiens
3.4.24.18 captopril
-
 Homo sapiens
3.4.24.18 galardin
-
 Homo sapiens
3.4.24.18 L-Pro-L-Leu-Gly-hydroxamate
-
 Homo sapiens
3.4.24.18 N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
-
 Homo sapiens
3.4.24.18 Ro 32-7315
-
 Homo sapiens
3.4.24.18 TAPI-0 i.e. tumour necrosis factor alpha protease inhibitor-0 Homo sapiens
3.4.24.18 TAPI-2 i.e. tumour necrosis factor alpha protease inhibitor-2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.18 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.18 Collagen IV + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.18 Fibronectin + H2O cleavage at positions Y294-Q295, N709-T210 and in the linker regions between fibronectin type I repeats 5 and 6 and fibronectin type II repeats 1 and 2 Homo sapiens ?
-
 ?
3.4.24.18 additional information no substrate: intact collagen I Homo sapiens ?
-
 ?
3.4.24.18 nidogen-1 + H2O cleavage at D67-R68 and Q363-H364 Homo sapiens ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.18 0.00002
-
 actinonin pH 7.5, 37°C Homo sapiens
3.4.24.18 0.00017
-
 galardin pH 7.5, 37°C Homo sapiens
3.4.24.18 0.0004
-
 N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid pH 7.5, 37°C Homo sapiens
3.4.24.18 0.00053
-
 L-Pro-L-Leu-Gly-hydroxamate pH 7.5, 37°C Homo sapiens
3.4.24.18 0.0015
-
 TAPI-2 pH 7.5, 37°C Homo sapiens
3.4.24.18 0.0016
-
 Ro 32-7315 pH 7.5, 37°C Homo sapiens
3.4.24.18 0.0022
-
 TAPI-0 pH 7.5, 37°C Homo sapiens
3.4.24.18 0.0044
-
 batimastat pH 7.5, 37°C Homo sapiens
3.4.24.18 0.074
-
 captopril pH 7.5, 37°C Homo sapiens