Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Grimm, M.; Haas, P.; Willipinski-Stapelfeldt, B.; Zimmermann, W.H.; Rau, T.; Pantel, K.; Weyand, M.; Eschenhagen, T.
    Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium (2005), Cardiovasc. Res., 65, 211-220.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 isoprenaline 80% activation at up to 0.01 mM Homo sapiens
2.7.11.18 phenylephrine 80% activation at up to 0.1 mM Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 ML-7 strong specific inhibition Homo sapiens
2.7.11.18 Wortmannin complete inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + [myosin light chain 2a] Homo sapiens MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae ADP + [myosin light chain 2a] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 atrium
-
 Homo sapiens
-
2.7.11.18 heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + [myosin light chain 2a]
-
 Homo sapiens ADP + [myosin light chain 2a] phosphate
-
 ?
2.7.11.18 ATP + [myosin light chain 2a] MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae Homo sapiens ADP + [myosin light chain 2a] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLC kinase
-
 Homo sapiens
2.7.11.18 MLCK
-
 Homo sapiens
2.7.11.18 myosin light chain kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Homo sapiens